Silicon-dioxide−polyvinylpyrrolidone as a wound dressing for skin defects in a murine model

Öri, Ferenc; Dietrich, Richard; Ganz, Cornelia; Dau, Michael; Wolter, Daniel J.; Kasten, Annika; Gerber, Thomas; Frerich, Bernhard

doi:10.1016/j.jcms.2016.10.002

Cited by 23 publications

(13 citation statements)

References 23 publications

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“…Silica microspheres maintained drug release (e.g., antibiotics) and enhanced the proliferation of fibroblast, whereas collagen adsorbed the exudates and rehydrated the necrotic tissues [185]. Likewise, silicon dioxide nanoparticles and polyvinylpyrrolidone (PVP) as a vehicle accelerated the migration and reepithelialisation, supporting the wound healing role of silicabased nanomaterials (Table 3) [187].…”

Section: (E) Silica Nanoparticles (Sinps)mentioning

confidence: 81%

Nanomaterials for application in wound Healing: current state-of-the-art and future perspectives

2022

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Nanoparticles are the gateway to the new era in drug delivery of biocompatible agents. Several products have emerged from nanomaterials in quest of developing practical wound healing dressings that are nonantigenic, antishear stress, and gas-exchange permeable. Numerous studies have isolated and characterised various wound healing nanomaterials and nanoproducts. The electrospinning of natural and synthetic materials produces fine products that can be mixed with other wound healing medications and herbs. Various produced nanomaterials are highly influential in wound healing experimental models and can be used commercially as well. This article reviewed the current state-of-the-art and briefly specified the future concerns regarding the different systems of nanomaterials in wound healing (i.e., inorganic nanomaterials, organic and hybrid nanomaterials, and nanofibers). This review may be a comprehensive guidance to help health care professionals identify the proper wound healing materials to avoid the usual wound complications.

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Section: (E) Silica Nanoparticles (Sinps)mentioning

confidence: 81%

Nanomaterials for application in wound Healing: current state-of-the-art and future perspectives

2022

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“…Dressings based on a silicon dioxide/polyvinylpyrrolidone composite were recently shown to accelerate the healing of full-thickness dermal wounds in a murine model by enhancing wound contraction and re-epithelialization [154]. Histological examination of the wounds revealed that the composite improved epidermal differentiation and the multi-stratified layer structure, which would be a consequence of improved vascularization of the regenerated tissue.…”

Section: Moist and Interactive Dressingsmentioning

confidence: 99%

Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies

Rousselle

Braye

Dayan

2019

Advanced Drug Delivery Reviews

403

278

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Cutaneous wound healing in adult mammals is a complex multi-step process involving overlapping stages of blood clot formation, inflammation, re-epithelialization, granulation tissue formation, neovascularization, and remodelling. Re-epithelialization describes the resurfacing of a wound with new epithelium. The cellular and molecular processes involved in the initiation, maintenance, and completion of epithelialization are essential for successful wound closure. A variety of modulators are involved, including growth factors, cytokines, matrix metalloproteinases, cellular receptors, and extracellular matrix components. Here, we focus on cellular mechanisms underlying keratinocyte migration and proliferation during epidermal closure. Inability to re-epithelialize is a clear indicator of chronic non-healing wounds, which fail to proceed through the normal phases of wound healing in an orderly and timely manner. This review summarizes the current knowledge regarding the management and treatment of acute and chronic wounds, with a focus on re-epithelialization, offering some insights into novel future therapies.

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“…Polyvinylpyrrolidone (PVP) is a hydrophilic, muco-adhesive polymer with good hemocompatibility and biocompatibility [24], which belongs to the "GRAS" group (Generally recognized as safe) by FDA (Food and Drug Administration, USA) [25]. Due to this, PVP has been used for many years as a broad-purpose biomaterial for blood substitutes [26], vitreous substitutes [27], as the main component for wound dressing coatings [28][29][30] and for the delivery of drugs and genes [31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications

et al. 2021

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Today, the synthesis of biocompatible and bioresorbable composite materials such as “polymer matrix-mineral constituent,” which stimulate the natural growth of living tissues and the restoration of damaged parts of the body, is one of the challenging problems in regenerative medicine. In this study, composite films of bioresorbable polymers of polyvinylpyrrolidone (PVP) and sodium alginate (SA) with hydroxyapatite (HA) were obtained. HA was introduced by two different methods. In one of them, it was synthesized in situ in a solution of polymer mixture, and in another one, it was added ex situ. Phase composition, microstructure, swelling properties and biocompatibility of films were investigated. The crosslinked composite PVP-SA-HA films exhibit hydrogel swelling characteristics, increasing three times in mass after immersion in a saline solution. It was found that composite PVP-SA-HA hydrogel films containing HA synthesized in situ exhibited acute cytotoxicity, associated with the presence of HA synthesis reaction byproducts—ammonia and ammonium nitrate. On the other hand, the films with HA added ex situ promoted the viability of dental pulp stem cells compared to the films containing only a polymer PVP-SA blend. The developed composite hydrogel films are recommended for such applications, such as membranes in osteoplastic surgery and wound dressing.

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Silicon-dioxide−polyvinylpyrrolidone as a wound dressing for skin defects in a murine model

Cited by 23 publications

References 23 publications

Nanomaterials for application in wound Healing: current state-of-the-art and future perspectives

Nanomaterials for application in wound Healing: current state-of-the-art and future perspectives

Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies

Composite Polyvinylpyrrolidone–Sodium Alginate—Hydroxyapatite Hydrogel Films for Bone Repair and Wound Dressings Applications

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