Silicon incorporation into hydroxyapatite nanocarrier counteracts the side effects of vancomycin for efficient chronic osteomyelitis treatment

Osteomyelitis is a destructive disease of bone tissue caused by infection with pathogenic microorganisms. Because of the complex and long-term abnormal conditions, osteomyelitis is one of the refractory diseases in orthopedics. Currently, anti-infective therapy is the primary modality for osteomyelitis therapy in addition to thorough surgical debridement. However, bacterial resistance has gradually reduced the benefits of traditional antibiotics, and the development of advanced antibacterial agents has received growing attention. This review introduces the main targets of antibacterial agents for treating osteomyelitis, including bacterial cell wall, cell membrane, intracellular macromolecules, and bacterial energy metabolism, focuses on their mechanisms, and predicts prospects for clinical applications.

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Section: Inhibition Of Biosynthesismentioning

confidence: 99%

Flourishing Antibacterial Strategies for Osteomyelitis Therapy

et al. 2023

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“…303,304 Although nanoparticles or hydrogels can improve the therapeutic efficiency of antibiotics and reduce the dosage, such intervention methods become helpless in the face of superbugs. 305,306 In recent years, as a bright direction of SACs, PTT-assisted enzymatic treatment has been established to have excellent therapeutic effect on tumors. However, when osteomyelitis occurs in the bone marrow cavities, the poor penetration depth of light will obviously limit the efficacy of phototherapy, far from meeting the therapeutic requirements for those patients with deep bone marrow infection.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Engineering single-atom catalysts toward biomedical applications

Chang

Zhang

et al. 2022

Chem. Soc. Rev.

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“…Due to its structural similarity to biological bone, visible biocompatibility, and bioactivity, HAp has been applied in medicine and dentistry in several forms: as dense sintered ceramics; porous forms; granules; and coatings of metal implants [ 8 , 9 , 10 ]. The shape of HAp crystallites is highly anisotropic, with at least two types of crystal faces: (100) and (101), and rarely (001), exhibiting different distributions of electrostatic potential, different interactions with water, and different adsorptions of biomolecules [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Nature-Inspired Effects of Naturally Occurring Trace Element-Doped Hydroxyapatite Combined with Surface Interactions of Mineral-Apatite Single Crystals on Human Fibroblast Behavior

Tyszka-Czochara

Suder

Dołhańczuk-Śródka

et al. 2022

IJMS

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Innovative engineering design for biologically active hydroxyapatites requires enhancing both mechanical and physical properties, along with biocompatibility, by doping with appropriate chemical elements. Herein, the purpose of this investigation was to evaluate and elucidate the model of naturally occurring hydroxyapatite and the effects of doped trace elements on the function of normal human fibroblasts, representing the main cells of connective tissues. The substrates applied (geological apatites with hexagonal prismatic crystal habit originated from Slyudyanka, Lake Baikal, Russia (GAp) and from Imilchil, The Atlas Mountains, Morocco (YAp)) were prepared from mineral natural apatite with a chemical composition consistent with the building blocks of enamel and enriched with a significant F− content. Materials in the form of powders, extracts and single-crystal plates have been investigated. Moreover, the effects on the function of fibroblasts cultured on the analyzed surfaces in the form of changes in metabolic activity, proliferation and cell morphology were evaluated. Apatite plates were also evaluated for cytotoxicity and immune cell activation capacity. The results suggest that a moderate amount of F− has a positive effect on cell proliferation, whereas an inhibitory effect was attributed to the Cl− concentration. It was found that for (100) GAp plate, fibroblast proliferation was significantly increased, whereas for (001) YAp plate, it was significantly reduced, with no cytotoxic effect and no immune response from macrophages exposed to these materials. The study of the interaction of fibroblasts with apatite crystal surfaces provides a characterization relevant to medical applications and may contribute to the design of biomaterials suitable for medical applications and the evaluation of their bioavailability.

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Silicon incorporation into hydroxyapatite nanocarrier counteracts the side effects of vancomycin for efficient chronic osteomyelitis treatment

Cited by 20 publications

References 42 publications

Flourishing Antibacterial Strategies for Osteomyelitis Therapy

Flourishing Antibacterial Strategies for Osteomyelitis Therapy

Engineering single-atom catalysts toward biomedical applications

Nature-Inspired Effects of Naturally Occurring Trace Element-Doped Hydroxyapatite Combined with Surface Interactions of Mineral-Apatite Single Crystals on Human Fibroblast Behavior

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