Silicon nanocrystals as photosensitizers of active oxygen for biomedical applications

Timoshenko, V. Yu.; Kudryavtsev, A. A.; Осминкина, Л. А.; Воронцов, А. А.; Ryabchikov, Yury V.; Belogorokhov, I. A.; Ковалев, Д. И.; Кашкаров, П. К.

doi:10.1134/s0021364006090128

Cited by 95 publications

(61 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This synthetic method also employs an etching process, combining HF/HNO 3 with sonication to remove the oxide and reduce the size of the particles. Silicon nanoparticles have been proposed as better quantum dots for in vivo applications [20,2] and for photodynamic therapy [25]. While the etching processes described above does not hinder the applications of these nanoparticles, a direct method for preparing hydrogen terminated silicon nanoparticles with less processing would be an improvement.…”

Section: Introductionmentioning

confidence: 99%

A new solution route to hydrogen-terminated silicon nanoparticles: synthesis, functionalization and water stability

et al. 2007

View full text Add to dashboard Cite

Hydrogen capped silicon nanoparticles with strong blue photoluminescence were synthesized by the metathesis reaction of sodium silicide, NaSi, with NH 4 Br. The hydrogen capped Si nanoparticles were further terminated with octyl groups and then coated with a polymer to render them water soluble. The nanoparticles were characterized by TEM, FT-IR, UV-VIS absorption, and photoluminescence. The Si nanoparticles were shown to have an average diameter of 3.9 ±1.3 nm and exhibited room-temperature photoluminescence with a peak maximum at 438 nm with a quantum efficiency of 32% in hexane and 18% in water; the emission was stable in ambient air for up to 2 months. These nanoparticles could hold great potential as a non-heavy element containing quantum dot for applications in biology.

show abstract

Section: Introductionmentioning

confidence: 99%

A new solution route to hydrogen-terminated silicon nanoparticles: synthesis, functionalization and water stability

et al. 2007

View full text Add to dashboard Cite

show abstract

“…First, Si NPs are not only biocompatible12, but also biodegradable as in biological tissue they normally decay into orthosilicic acid Si(OH) 4 , which is naturally excreted from the body through the urine13. Second, due to a series of unique properties, including room temperature photoluminescence1213, singlet oxygen generation under photoexcitation14, infrared radiation–induced15 and ultrasound-induced16 hyperthermia, Si NPs can offer diagnostic1718 and alternative treatment modalities (e.g., Photodynamic Therapy1920) that can be applied in parallel to the RF hyperthermia approach.…”

mentioning

confidence: 99%

Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy

Tamarov

Осминкина

Zinovyev

et al. 2014

Sci Rep

159

156

View full text Add to dashboard Cite

Offering mild, non-invasive and deep cancer therapy modality, radio frequency (RF) radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively target cancer cells and thus avoid side effects. Here, we assess crystalline silicon (Si) based nanomaterials as sensitizers for the RF-induced therapy. Using nanoparticles produced by mechanical grinding of porous silicon and ultraclean laser-ablative synthesis, we report efficient RF-induced heating of aqueous suspensions of the nanoparticles to temperatures above 45-50°C under relatively low nanoparticle concentrations (<1 mg/mL) and RF radiation intensities (1–5 W/cm2). For both types of nanoparticles the heating rate was linearly dependent on nanoparticle concentration, while laser-ablated nanoparticles demonstrated a remarkably higher heating rate than porous silicon-based ones for the whole range of the used concentrations from 0.01 to 0.4 mg/mL. The observed effect is explained by the Joule heating due to the generation of electrical currents at the nanoparticle/water interface. Profiting from the nanoparticle-based hyperthermia, we demonstrate an efficient treatment of Lewis lung carcinoma in vivo. Combined with the possibility of involvement of parallel imaging and treatment channels based on unique optical properties of Si-based nanomaterials, the proposed method promises a new landmark in the development of new modalities for mild cancer therapy.

show abstract

“…Two major pathways have been described for their synthesis. Kovalev's method (Timoshenko et al 2006) consists of obtaining silicon nanocrystals using electrochemical etching of silicon wafers in a hydrofluoric acid solution. This treatment led to porous silicon layers which were mechanically milled (ultrasonic bath).…”

Section: Silicon Nanoparticlesmentioning

confidence: 99%

Nanoparticles for Photodynamic Therapy Applications

Vanderesse

Frochot

Barberi‐Heyob

et al. 2011

Intracellular Delivery

View full text Add to dashboard Cite

Photodynamic therapy has emerged as an alternative to chemo-and radiotherapy for the treatment of certain types of cancer. Nanoparticles have been used to improve the delivery and the efficiency of the photosensitizer as they allow its encapsulation without loss of activity. Using targeting strategies, they can also allow the selective accumulation of the photosensitizer in the cancer tissues. In this review, based on the chemical nature of the nanoparticles, the different methods for their syntheses are described from the pioneering works to the latest achievements. Indeed the nanosystems can be conjugated to a biomolecule or an antibody to target receptors over-expressed in cancer cells and/or angiogenic vascular endothelial cells. Numerous in vivo and in vitro applications have been described. Multifunctional nanoplatforms combining several applications within the same nano-object emerge as potential important theranostic tools.

show abstract

Silicon nanocrystals as photosensitizers of active oxygen for biomedical applications

Cited by 95 publications

References 12 publications

A new solution route to hydrogen-terminated silicon nanoparticles: synthesis, functionalization and water stability

A new solution route to hydrogen-terminated silicon nanoparticles: synthesis, functionalization and water stability

Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy

Nanoparticles for Photodynamic Therapy Applications

Contact Info

Product

Resources

About