Silicon nanoneedles for drug delivery

Chiappini, Ciro; Almeida, Carina S.

doi:10.1533/9780857097712.2.144

Cited by 12 publications

(7 citation statements)

References 72 publications

(112 reference statements)

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“…Among such nanotools, various types of the ordered array silicon nanowire (SiNW) have been investigated for enhancement of growth and spreading of various cell lines , and delivery of biomolecules into cells. − It is known that the density of nanowires is an important process of the adhesion and size . Although the low density nanowires do not support cell proliferation or migration, they can incorporate various biomolecules into the cell by partial membrane penetration .…”

Section: Introductionmentioning

confidence: 99%

High Density of Aligned Nanowire Treated with Polydopamine for Efficient Gene Silencing by siRNA According to Cell Membrane Perturbation

Nair

Hagiwara

Ueda

et al. 2016

ACS Appl. Mater. Interfaces

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High aspect ratio nanomaterials, such as vertically aligned silicon nanowire (SiNW) substrates, are three-dimensional topological features for cell manipulations. A high density of SiNWs significantly affects not only cell adhesion and proliferation but also the delivery of biomolecules to cells. Here, we used polydopamine (PD) that simply formed a thin coating on various material surfaces by the action of dopamine as a bioinspired approach. The PD coating not only enhanced cell adhesion, spreading, and growth but also anchored more siRNA by adsorption and provided more surface concentration for substrate-mediated delivery. By comparing plain and SiNW surfaces with the same amount of loaded siRNA, we quantitatively found that PD coating efficiently anchored siRNA on the surface, which knocked down the expression of a specific gene by RNA interference. It was also found that the interaction of SiNWs with the cell membrane perturbed the lateral diffusion of lipids in the membrane by fluorescence recovery after photobleaching. The perturbation was considered to induce the effective delivery of siRNA into cells and allow the cells to carry out their biological functions. These results suggest promising applications of PD-coated, high-density SiNWs as simple, fast, and versatile platforms for transmembrane delivery of biomolecules.

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Section: Introductionmentioning

confidence: 99%

High Density of Aligned Nanowire Treated with Polydopamine for Efficient Gene Silencing by siRNA According to Cell Membrane Perturbation

Nair

Hagiwara

Ueda

et al. 2016

ACS Appl. Mater. Interfaces

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“…There are many types of nano needles such as solid, porous and hollow nano needles based on the loading and release characteristics of the needle. 19 Nowadays needles with nanosized stainless steel crystals incorporated into them are available commercially (Sandvik Bioline 1RK91™, Sandvik, smt.sandvik.com). 12 Nanotweezers are nano devices which help in the construction of the human cell.…”

Section: Nanoneedles and Nanotweezersmentioning

confidence: 99%

An Exploratory Review of Current Trends in Nanodentistry

REDDY

CRENA.M

PSG

et al. 2022

Cumhuriyet Dental Journal

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Nanotechnology is a cutting-edge concept that is evolving manifolds in various fields of science and medicine and is by no means exceptional to dentistry. Nanotechnology is popularly known as the 'science of the small' that deals with particles of size 1-10nm. Methods like top-down or bottom-up approaches are used in manufacturing nanoparticles and nanorobots, catering to the needs of medical diagnostics and therapeutics. Nanorobotics advances medicine through miniaturization from microelectronics to nanoelectronics. Nanotechnology can be applied to all fields of dentistry such as to create nano implants, nano-drug delivery systems, nanocomposites and nano impression materials. Additionally, it helps in orthodontic tooth movement, alleviating hypersensitivity, and effective anesthesia. This paper highlights the various applications of nanotechnology in dentistry and also mentions the clinical trials performed to have a more focused approach to practicing nanodentistry. Apart from this the paper briefly explains the benefits of integrating artificial intelligence and nanotechnology for creating more personalized treatment options and also its role in Covid 19 vaccines.

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“…Nanoparticles that are shaped with sharp points or edges can mechanically damage the cell membrane, creating temporary nanochannels through which they can enter the cytoplasm [ 33 ]. This can be exploited to create drug delivery mechanisms by coating nanoparticles such as carbon nanotubes with biocompatible molecules which attach and enter cells, or manufacturing nanoneedles from materials such as silicon or polymers that can mechanically puncture cells to deliver drugs directly into the cytoplasm [ 34 , 35 ]; however, toxic nanomaterials could very easily enter cells by the same mechanism and induce cytotoxic effects.…”

Section: Nanomaterials Exposure Pathways In Biologymentioning

confidence: 99%

The Use of Microfluidics in Cytotoxicity and Nanotoxicity Experiments

et al. 2017

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Many unique chemical compounds and nanomaterials are being developed, and each one requires a considerable range of in vitro and/or in vivo toxicity screening in order to evaluate their safety. The current methodology of in vitro toxicological screening on cells is based on well-plate assays that require time-consuming manual handling or expensive automation to gather enough meaningful toxicology data. Cost reduction; access to faster, more comprehensive toxicity data; and a robust platform capable of quantitative testing, will be essential in evaluating the safety of new chemicals and nanomaterials, and, at the same time, in securing the confidence of regulators and end-users. Microfluidic chips offer an alternative platform for toxicity screening that has the potential to transform both the rates and efficiency of nanomaterial testing, as reviewed here. The inherent advantages of microfluidic technologies offer high-throughput screening with small volumes of analytes, parallel analyses, and low-cost fabrication.

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Silicon nanoneedles for drug delivery

Cited by 12 publications

References 72 publications

High Density of Aligned Nanowire Treated with Polydopamine for Efficient Gene Silencing by siRNA According to Cell Membrane Perturbation

High Density of Aligned Nanowire Treated with Polydopamine for Efficient Gene Silencing by siRNA According to Cell Membrane Perturbation

An Exploratory Review of Current Trends in Nanodentistry

The Use of Microfluidics in Cytotoxicity and Nanotoxicity Experiments

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