Silicon nanoparticles as a fluorometric probe for sensitive detection of cyanide ion and its application in C. elegans bio-imaging

Alagarasan, Jagadeesh Kumar; Shasikala, Siddharthy; Ganesan, Sivarasan; Manimekalan, A; Manojkumar, Utaiyachandran; Senthilkumar, Palaninaicker; Nguyen, Dinh Duc; Chang, Soon Wong; Lee, Moonyong; Lo, Huang‐Mu

doi:10.1016/j.envres.2023.115402

Cited by 10 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fiber optical sensors with Au@Ag exhibited a great advantage of ultrahigh sensitivity over conventional methodologies, such as using fluorometry and colorimetry − while ensuring sufficient operation range of CN – concentration for CN – quantitative sensors. Table summarizes the recently reported cyanide detection compared with the results presented in this work.…”

Section: Resultsmentioning

confidence: 99%

Ultrasensitive Monitoring of Cyanide Concentrations in Water Using a Au_core–Ag_shell Hybrid-Coating-Based Fiber Optical Sensor

Phuong,

Phung,

et al. 2023

Langmuir

View full text Add to dashboard Cite

Cyanides, which are extremely toxic chemicals that are rapidly absorbed into the human body and interact with cytochrome oxidase, strongly inhibit cellular respiration to body death with convulsions. Cyanide ions that exist in many forms in nature such as those found in apricot kernels, cassava roots, and bamboo shoots as cyanogenic glycosides are inevitably used in various industries, including gold and silver mining as well as in dyes and plastic industries. In this study, for the sake of developing ultrahigh-sensitive sensors for cyanide monitoring in a simple manner, we chemically synthesize Au core −Ag shell hybrid nanomaterials of different core/shell thicknesses for colorimetric sensors and fiber optical sensors. Their sensing principle relies on the formation of the Ag/Au cyanocomplex upon cyanide injection. The generated metal cyanocomplex induced changes in refractive indices, causing changes in properties of localized surface plasmon resonance (LSPR), i.e., optical absorbance change for the colorimetric sensors. For fiber optical sensors, the hybrid metal nanoparticles were immobilized on the fiber core surface and the metal cyanocomplex formation induced changes in the fiber cladding refractive index, enabling quantitative cyanide detection with ultrahigh sensitivity. The LSPR-based colorimetric sensor provided the lowest detectable cyanide concentration of 5 × 10 −6 M, whereas the value for the fiber-based sensor was 8 × 10 −11 M.

show abstract

Section: Resultsmentioning

confidence: 99%

Ultrasensitive Monitoring of Cyanide Concentrations in Water Using a Au_core–Ag_shell Hybrid-Coating-Based Fiber Optical Sensor

Phuong,

Phung,

et al. 2023

Langmuir

View full text Add to dashboard Cite

show abstract

“…Recently, it was found that silicon nanoparticles (SiNPs) have garnered substantial attention due to their remarkable attributes, such as ease of use, cost-effectiveness, compatibility with biological systems, and resilience to light degradation. 19 Based on their safety and low toxicity, Si-based biosensors might specifically be applied as markers within the human body. 20 Consequently, SiNPs hold a strong application position related to biosensors and bioimaging.…”

Section: ■ Introductionmentioning

confidence: 99%

Triple Sensing Modes for Triggered β-Galactosidase Activity Assays Based on Kaempferol-Deduced Silicon Nanoparticles and Biological Imaging of MCF-7 Breast Cancer Cells

Iradukunda,

Kang,

Zhao

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

β-Galactosidase (β-Gala) is an essential biomarker enzyme for early detection of breast tumors and cellular senescence. Creating an accurate way to monitor β-Gala activity is critical for biological research and early cancer detection. This work used fluorometric, colorimetric, and paper-based color sensing approaches to determine β-Gala activity effectively. Via the sensing performance, the catalytic activity of β-Gala resulted in silicon nanoparticles (SiNPs), fluorescent indicators obtained via a one-pot hydrothermal process. As a standard enzymatic hydrolysis product of the substrate, kaempferol 3-O-β-D-galactopyranoside (KOβDG) caused the fluorometric signal to be attenuated on kaempferol-silicon nanoparticles (K-SiNPs). The sensing methods demonstrated a satisfactory linear response in sensing β-Gala and a low detection limit. The findings showed the low limit of detection (LOD) as 0.00057 and 0.098 U/mL for fluorometric and colorimetric, respectively. The designed probe was then used to evaluate the catalytic activity of β-Gala in yogurt and human serum, with recoveries ranging from 98.33 to 107.9%. The designed sensing approach was also applied to biological sample analysis. In contrast, breast cancer cells (MCF-7) were used as a model to test the in vitro toxicity and molecular fluorescence imaging potential of K-SiNPs. Hence, our fluorescent K-SiNPs can be used in the clinic to diagnose breast cellular carcinoma, since they can accurately measure the presence of invasive ductal carcinoma in serologic tests.

show abstract

“…Cyanidation, the most common process for silver and gold lixiviation, involves the transfer of minerals into an aqueous solution containing NaCN, where metals are complexed by CN À , and later extracted [5,6]. The cyanide complexes of copper and nickel are commonly referred to as weak acid dissociable cyanide (CN-WAD) [7,8]. Due to the high toxicity of these species, continuous in-situ monitoring of CN-WAD is imperative [4].…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have focused on detecting CN-WAD using various techniques, including colorimetric [9][10][11][12], fluorometric [8], potentiometric [13], and electrochemical techniques. [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Monitoring WAD cyanide concentration in river waters with a glassy carbon electrode modified with 9,10‐Phenanthroquinone

Cardenas‐Riojas,

Calderon‐Zavaleta,

Quiroz‐Aguinaga

et al. 2023

Electroanalysis

View full text Add to dashboard Cite

Heavy metal‐containing industrial effluent streams from electroplating and metalworking industries represent a major environmental issue. They contain metal cyanide complexes ([Ni(CN)4]2− and [Cu(CN)3]2−) referred to as weak acid dissociable cyanide (CN‐WAD), which require continuous in situ monitoring. In this scenario, a glassy carbon (GC) electrode superficially decorated with 9,10‐phenanthroquinone (FNQ) is manufactured and employed for the simultaneous electrochemical monitoring of cyanide WAD complexes. The interaction between GC and FNQ was characterized by Raman and electrochemical impedance spectroscopies, cyclic voltammetry, and chronocoulometry. The electrochemical evaluation was conducted by differential pulse voltammetry (DPV) and CV. The GC/FNQ electrochemical sensor simultaneously detected cyanide complexes with an average linear range of 9–93 μmol L−1, and a detection limit of 0.15±0.04 μmol L−1 and 1.2±0.6 μmol L−1 for [Ni(CN)4]2− and [Cu(CN)3]2−, respectively. The sensor demonstrated remarkable selectivity in the presence of multiple interfering species with a percentage variation range of 89.2–109.4 %. Moreover, a computational DFT study provided valuable insights into the electrode/electrolyte interface. Finally, the developed sensor was applied for the electrochemical detection of WAD cyanide in river water samples.

show abstract

Silicon nanoparticles as a fluorometric probe for sensitive detection of cyanide ion and its application in C. elegans bio-imaging

Cited by 10 publications

References 34 publications

Ultrasensitive Monitoring of Cyanide Concentrations in Water Using a Au_core–Ag_shell Hybrid-Coating-Based Fiber Optical Sensor

Ultrasensitive Monitoring of Cyanide Concentrations in Water Using a Au_core–Ag_shell Hybrid-Coating-Based Fiber Optical Sensor

Triple Sensing Modes for Triggered β-Galactosidase Activity Assays Based on Kaempferol-Deduced Silicon Nanoparticles and Biological Imaging of MCF-7 Breast Cancer Cells

Monitoring WAD cyanide concentration in river waters with a glassy carbon electrode modified with 9,10‐Phenanthroquinone

Contact Info

Product

Resources

About

Silicon nanoparticles as a fluorometric probe for sensitive detection of cyanide ion and its application in C. elegans bio-imaging

Cited by 10 publications

References 34 publications

Ultrasensitive Monitoring of Cyanide Concentrations in Water Using a Aucore–Agshell Hybrid-Coating-Based Fiber Optical Sensor

Ultrasensitive Monitoring of Cyanide Concentrations in Water Using a Aucore–Agshell Hybrid-Coating-Based Fiber Optical Sensor

Triple Sensing Modes for Triggered β-Galactosidase Activity Assays Based on Kaempferol-Deduced Silicon Nanoparticles and Biological Imaging of MCF-7 Breast Cancer Cells

Monitoring WAD cyanide concentration in river waters with a glassy carbon electrode modified with 9,10‐Phenanthroquinone

Contact Info

Product

Resources

About

Ultrasensitive Monitoring of Cyanide Concentrations in Water Using a Au_core–Ag_shell Hybrid-Coating-Based Fiber Optical Sensor

Ultrasensitive Monitoring of Cyanide Concentrations in Water Using a Au_core–Ag_shell Hybrid-Coating-Based Fiber Optical Sensor