Silicon Nanostructures for Cancer Diagnosis and Therapy

Peng, Fei; Cao, Zhaohui; Ji, Xiaoyuan; Chu, Binbin; Su, Yuanyuan; He, Yao

doi:10.2217/nnm.15.53

Cited by 27 publications

(12 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One is through the use of nanomaterials as a drug carrier for cancer treatment, such as antitumor drugs, therapeutic genes and antibodies. [9][10][11] The other is based on unique properties of nanoparticles (NPs) such as the photothermal e®ects from some of the well-known nanomaterials: TiO 2 , gold and carbon nanotubes. [12][13][14][15] With the development of nanotechnology, more and more synergistic treatments have also been reported.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Nanotechnology for Breast Cancer Therapy

Qin

Lian

et al. 2019

Nano LIFE

View full text Add to dashboard Cite

Breast cancer is one of the most critical threats to women worldwide. The incidence and mortality of breast cancer are as high as 24.2% and 15%, respectively, ranking first in female malignant tumors. Although the main treatments for breast cancer include surgery, radiotherapy and chemotherapy, side effects and drug resistance are the main problems in conventional chemotherapy. In recent years, nanotechnologies have offered high potentials in cancer therapeutics due to unique physicochemical and biological properties of nanomaterials. The outcomes of nanomaterials research have shown effective solutions to critical issues that have not been well addressed by conventional medicine. In this review paper, we introduce the latest progress of nanotechnology in the treatment of breast cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Recent Advances in Nanotechnology for Breast Cancer Therapy

Qin

Lian

et al. 2019

Nano LIFE

View full text Add to dashboard Cite

show abstract

“…One-dimensional (1D) silicon nanostructures have attracted considerable interest in the past decade because of their unique morphologies and electronic-optical properties that render them suitable for a broad spectrum of applications, such as field-effect transistor, drug carrier, solar cell, nanomechanical device, and lithium-ion battery [22][23][24][25][26]. Consequently, preparation and characterization of 1D silicon nanostructures, such as nanowires and nanorods, have recently drawn extensive attention [27,28].…”

Section: Introductionmentioning

confidence: 99%

Ethylene glycol-mediated synthetic route for production of luminescent silicon nanorod as photodynamic therapy agent

et al. 2017

View full text Add to dashboard Cite

One-dimensional silicon nanorod (SiNR) has attracted considerable interest because of its unique morphology and electronic-optical properties that render SiNRs suitable for a broad spectrum of applications, such as fieldeffect transistor, drug carrier, solar cell, nanomechanical device, and lithium-ion battery. However, studies aiming to identify a new synthetic method and apply SiNR in the biomedical field remain limited. This study is the first to use an ethylene glycol-mediated synthetic route to prepare SiNR as a multicolor fluorescent probe and a new photodynamic therapy (PDT) agent. The as-prepared SiNR demonstrates bright fluorescence, excellent storage and photostability, favorable biocompatibility, excitation-dependent emission, and measurable quantity of 1 O 2 (0.24). On the basis of these features, we demonstrate through in vitro studies that the SiNR can be utilized as a new nanophotosensitizer for fluorescence imaging-guided cancer treatment. Our work leads to a new production process for SiNRs that can be used not only as PDT agents for therapy of shallow tissue cancer but also as excellent, environment-friendly, and red light-induced photocatalysts for the degradation of persistent organic pollutants in the future.

show abstract

“…The optical property together with good biocompatibility of silicon make silicon nanostructures a promising candidate for widespread applications from electronics to biomedicine. As a representative zero‐dimensional silicon nanostructure, fluorescent silicon nanoparticles (SiNPs) have several intrinsic advantages for optical applications, including plentiful and inexpensive resources, compatibility with the existing silicon industry, and non‐ or low toxicity, etc . Specifically, silicon is the element with the second‐highest abundancy in the earth's crust, only behind oxygen, and bulk silicon has dominated the semiconductor industry for over 50 years.…”

Section: Introductionmentioning

confidence: 99%

“…For example, the emission color of H‐SiNPs is changed from red to blue due to oxidization when they are exposed to air in the presence of nitrogen compounds . Considerable efforts have been made toward the development of novel synthetic strategies (e.g., microemulsions, high‐temperature processes, and microwave‐assisted synthesis) that have highly efficacy for the synthesis of SiNPs simultaneously featuring superior optical properties and strong chemical‐/photostability . In addition, a variety of functionalized SiNPs with improved properties can be constructed through specific types of surface modification.…”

Section: Introductionmentioning

confidence: 99%

“…Based on the tremendous advances in the preparation of high‐performance fluorescent SiNPs, scientists have further exploited their applications in a wide range of fields, including as contrast agents for bioimaging, as fluorescence probes for sensing, as emissive‐layer materials for light‐emitting diode (LED) devices, as capacity anode materials for lithium‐ion batteries, and as catalysts . Here, we discuss concisely the latest exciting developments of the synthesis approaches for water‐dispersible fluorescent silicon nanoparticles and their optical applications.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Water‐Dispersible Fluorescent Silicon Nanoparticles and their Optical Applications

2016

Advanced Materials

Self Cite

View full text Add to dashboard Cite

Fluorescent silicon nanoparticles (SiNPs) attract considerable attention owing to their intrinsic advantages, including relatively strong fluorescence coupled with robust photostability, rich resource support and relatively low cost, industrial maturity, and good biocompatibility. Extensive efforts are devoted to developing effective methods for the synthesis of hydrogen or halogen-terminated SiNPs, which nevertheless need further surface modification to improve their stability and solubility for wide-ranging applications. Notably, recent years have witnessed the development of various aqueous synthetic strategies for direct preparation of highly fluorescent and photostable SiNPs in the aqueous phase, facilitating the promotion of this promising material for myriad optical applications. Here, a concise discussion of the latest exciting research progress of the preparation of SiNPs is given, with a focus on water-dispersible SiNPs synthesized in the aqueous phase. In addition, representative optical applications of SiNPs in bioimaging and sensing are also summarized. Finally, the opportunities and challenges of fluorescent-SiNP-based optical applications are discussed.

show abstract

Silicon Nanostructures for Cancer Diagnosis and Therapy

Cited by 27 publications

References 84 publications

Recent Advances in Nanotechnology for Breast Cancer Therapy

Recent Advances in Nanotechnology for Breast Cancer Therapy

Ethylene glycol-mediated synthetic route for production of luminescent silicon nanorod as photodynamic therapy agent

Water‐Dispersible Fluorescent Silicon Nanoparticles and their Optical Applications

Contact Info

Product

Resources

About