2021
DOI: 10.3389/fbioe.2021.794586
|View full text |Cite
|
Sign up to set email alerts
|

Silicon Nitride, a Bioceramic for Bone Tissue Engineering: A Reinforced Cryogel System With Antibiofilm and Osteogenic Effects

Abstract: Silicon nitride (SiN [Si3N4]) is a promising bioceramic for use in a wide variety of orthopedic applications. Over the past decades, it has been mainly used in industrial applications, such as space shuttle engines, but not in the medical field due to scarce data on the biological effects of SiN. More recently, it has been increasingly identified as an emerging material for dental and orthopedic implant applications. Although a few reports about the antibacterial properties and osteoconductivity of SiN have be… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
11
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
7
1
1

Relationship

2
7

Authors

Journals

citations
Cited by 19 publications
(12 citation statements)
references
References 79 publications
1
11
0
Order By: Relevance
“…Increased surface roughness reportedly promoted osteoblast spread and migration ( Jiang et al, 2013 ; Abar et al, 2021 ). In the cell viability tests, as an inorganic nanomaterial with excellent biocompatibility, Si 3 N 4 did not show significant cytotoxicity, consistent with previous reports ( Bock et al, 2015 ; Fiani et al, 2021 ; Lee et al, 2021 ). Regarding osteogenic differentiation, Si 3 N 4 doping significantly promoted ALP and mineralization compared to the control group, possibly due to the slight dissolution of Si 3 N 4 in the body fluid environment and the slow release of Si 4+ .…”
Section: Resultssupporting
confidence: 91%
“…Increased surface roughness reportedly promoted osteoblast spread and migration ( Jiang et al, 2013 ; Abar et al, 2021 ). In the cell viability tests, as an inorganic nanomaterial with excellent biocompatibility, Si 3 N 4 did not show significant cytotoxicity, consistent with previous reports ( Bock et al, 2015 ; Fiani et al, 2021 ; Lee et al, 2021 ). Regarding osteogenic differentiation, Si 3 N 4 doping significantly promoted ALP and mineralization compared to the control group, possibly due to the slight dissolution of Si 3 N 4 in the body fluid environment and the slow release of Si 4+ .…”
Section: Resultssupporting
confidence: 91%
“…After 7 and 14 days of osteogenic induction, the ARS kit (0223, Sciencell research) was utilized by following the standard protocol [49]. Cells were fixed in 4 % PFA (281692, Santa Cruz Biotech) for 10 min and washed three times with distilled water.…”
Section: Ars Stainingmentioning
confidence: 99%
“…[ 58 ] These biomaterials are mostly used in the orthopedic field [ 59 ] for knee or hip joint replacement. [ 60 ] Several studies have demonstrated the ability of these silicon nitride‐based materials to promote osteogenesis, [ 61,62 ] to lyse bacteria such as S. epidermidis [ 58 ] or Porphyromonas g ingivalis [ 63 ] and to inactivate viruses such as SARS‐CoV‐2. [ 64 ] Therefore, this type of structure could be an interesting strategy to limit the risks of bacterial infections related to the implantation of osteoarticular prosthesis.…”
Section: No Deliverymentioning
confidence: 99%