Silicon Nitride Induces Osteoconduction Via Activated Mitochondrial Oxidative Phosphorylation and Neovascularization
Wayne Gonzales,
Ronit Khade,
Takeru Kondo
et al.
Abstract:Silicon Nitride (Si3N4: SiN) is a thermodynamically stable ceramic material with excellent mechanical properties and wear/corrosion resistance for industrial applications. SiN is also proposed for orthopedic and dental implant applications because of its enhanced osteoconduction. However, the biological mechanism of SiN-induced bone formation has not been fully elucidated. In this study, SiN significantly increasedin vitromineralization of human bone marrow mesenchymal stromal cells (BM-MSC) andin vivoperi-imp… Show more
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