Silicon oxycarbide glasses for blood-contact applications

Zhuo, Rui; Colombo, Paolo; Pantano, Carlo G.; Vogler, Erwin A.

doi:10.1016/j.actbio.2005.05.005

Cited by 81 publications

(64 citation statements)

References 25 publications

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“…Clearly, an improved understanding of the events leading to thrombus formation on biomaterials is needed that will define new bioengineering routes to hemocompatibility. An approach we have taken has been to simplify the problem down to the minimum essential unit of study [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…A complex formed from PK, Factor XI, and surface-bound HMWK is thought to bring all factors and co-factors into reactive proximity [19,24]. We have pursued studies of whole-plasma coagulation seeking to resolve detailed relationships among biomaterial surface chemistry, energy, and the propensity to activate the intact plasma coagulation cascade [6][7][8][9][10][11][12]. Results of these 'holistic' studies [11] have motivated us to serially simplify the focus of investigation from whole plasma, to a group of coagulation proteins, to finally purified enzymes of the cascade as a means of comparing activation of the pieces to activation of the whole [10,11,25].…”

Section: Introductionmentioning

confidence: 99%

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Competitive-protein adsorption in contact activation of blood factor XII☆☆☆

Zhuo¹,

Siedlecki

Vogler

2007

Biomaterials

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Contact activation of blood factor XII (FXII, Hageman factor) is moderated by the protein composition of the fluid phase in which FXII is dissolved. Solution yield of FXIIa arising from FXII contact with hydrophilic activating particles (fully water-wettable glass) suspended in a protein cocktail is shown to be significantly greater than that obtained under corresponding activation conditions in buffer solutions containing only FXII. By contrast, solution yield of FXIIa arising from FXII contact with hydrophobic particles (silanized glass) suspended in protein cocktail is sharply lower than that obtained in buffer. This confirms that contact activation is not specific to anionic hydrophilic surfaces as proposed by the accepted biochemistry of surface activation. Rather, contact activation in the presence of proteins unrelated to the plasma coagulation cascade leads to an apparent specificity for hydrophilic surfaces that is actually due to a relative diminution of activation at hydrophobic surfaces and an enhancement at hydrophilic surfaces. Furthermore, the rate of FXIIa accumulation in whole-plasma and buffer solution is found to decrease with time in the continuous presence of activating surfaces, leading to a steady-state FXIIa yield dependent on the initial FXII solution concentration for both hydrophilic and hydrophobic procoagulant particles suspended in either plasma, protein cocktail, or buffer. These results strongly suggest that activation competes with an autoinhibition reaction in which FXIIa itself inhibits FXII-->FXIIa. Experimental results are modeled using a reaction scheme invoking FXII activation and autoinhibition linked to protein adsorption to procoagulant surfaces, where FXII activation is presumed to proceed by either autoactivation (FXII-->surface-->FXIIa) and autohydrolysis (FXII-->FXIIa-->2FXIIa) in buffer solution or autoactivation and reciprocal activation (kallikrein-mediated hydrolysis) in plasma. FXII adsorption competition with other proteins in the fluid phase is proposed to affect the balance of activation and autoinhibition, leading to the observed moderation of FXIIa yield.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Competitive-protein adsorption in contact activation of blood factor XII☆☆☆

Zhuo¹,

Siedlecki

Vogler

2007

Biomaterials

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“…similar to silica glass) to nonactivating (e.g. similar to silanized glass (Zhuo et al 2005)). Moreover, through the addition of nano-sized fillers to a siloxane precursor it is possible to obtain ceramic components based on wollastonite (CaSiO 3 , which possesses excellent bioactivity (Xue et al 2005).…”

Section: Ceramization Of Particles and Capsulesmentioning

confidence: 99%

Ceramic microparticles and capsules via microfluidic processing of a preceramic polymer

Chen

Colombo

et al. 2010

J. R. Soc. Interface.

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We have developed a robust technique to fabricate monodispersed solid and porous ceramic particles and capsules from single and double emulsion drops composed of silsesquioxane preceramic polymer. A microcapillary microfluidic device was used to generate the monodispersed drops. In this device, two round capillaries are aligned facing each other inside a square capillary. Three fluids are needed to generate the double emulsions. The inner fluid, which flows through the input capillary, and the middle fluid, which flows through the void space between the square and inner fluid capillaries, form a coaxial co-flow in a direction that is opposite to the flow of the outer fluid. As the three fluids are forced through the exit capillary, the inner and middle fluids break into monodispersed double emulsion drops in a single-step process, at rates of up to 2000 drops s 21. Once the drops are generated, the silsesquioxane is cross-linked in solution and the cross-linked particles are dried and pyrolysed in an inert atmosphere to form oxycarbide glass particles. Particles with diameters ranging from 30 to 180 mm, shell thicknesses ranging from 10 to 50 mm and shell pore diameters ranging from 1 to 10 mm were easily prepared by changing fluid flow rates, device dimensions and fluid composition. The produced particles and capsules can be used in their polymeric state or pyrolysed to ceramic. This technique can be extended to other preceramic polymers and can be used to generate unique core -shell multimaterial particles.

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“…Changing the precursor can lead to formation of different black glasses, e.g., materials with or without free carbon phase [5,7,15,35]. From the variety of possible applications, at least few should be mentioned, i.e., anodes for Li-ion batteries [16], material for artificial heart valves [17], and protective coatings [4]. Most of the research focuses on two temperature ranges used to obtain SiOC glasses-below 400°C for low-k thin layers and above 1000°C, where phase separations occurs [4,10].…”

Section: Introductionmentioning

confidence: 99%

Thermal evolution of ladder-like silsesquioxanes during formation of black glasses

Jeleń

Szumera

Gawęda

et al. 2017

J Therm Anal Calorim

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Pyrolysis of ladder-like silsesquioxanes in oxygen-free atmosphere leads to the formation of silicon oxycarbides (black glasses). Black glasses are materials of amorphous silica structure where some amount of O 2-ions were replaced by C 4-ions. This exchange leads to local increase in bonds density and therefore improvement in mechanical, thermal, and chemical properties. Thanks to this modification, silicon oxycarbide glasses can be used in a variety of applications like: protective coatings and interconnectors in solid oxide fuel cells. Xerogels were prepared by sol-gel method, and ladder-like silsesquioxanes were used as precursors. Samples were burned at 200-1000°C in inert atmosphere. Structural studies in the middle infrared range (MIR) and SEM with EDX confirmed the presence of SiOC bonds in obtained materials. MIR analysis of solid samples together with TG/dTG measurements allowed defining the process for the formation of black glasses.

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Silicon oxycarbide glasses for blood-contact applications

Cited by 81 publications

References 25 publications

Competitive-protein adsorption in contact activation of blood factor XII☆☆☆

Competitive-protein adsorption in contact activation of blood factor XII☆☆☆

Ceramic microparticles and capsules via microfluidic processing of a preceramic polymer

Thermal evolution of ladder-like silsesquioxanes during formation of black glasses

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