Silicon Photonic Biosensors Using Label-Free Detection

Luan, Enxiao; Shoman, Hossam; Ratner, Daniel M.; Cheung, Karen C.; Chrostowski, Lukas

doi:10.3390/s18103519

Cited by 292 publications

(159 citation statements)

References 268 publications

(339 reference statements)

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“…These scalable and cost-effective on-chip biosensors can be interesting for a broad market in the future. In [144], biosensors based on silicon photonics (among ring resonators) are compared with respect to chip-scale integration and miniaturization with potential for low-cost, high yield and portability in applications also for point-of-care diagnosis.…”

Section: Fibers and Waveguides Without Structurementioning

confidence: 99%

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Gauglitz

2020

Anal Bioanal Chem

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Direct optical detection has proven to be a highly interesting tool in biomolecular interaction analysis to be used in drug discovery, ligand/receptor interactions, environmental analysis, clinical diagnostics, screening of large data volumes in immunology, cancer therapy, or personalized medicine. In this review, the fundamental optical principles and applications are reviewed. Devices are based on concepts such as refractometry, evanescent field, waveguides modes, reflectometry, resonance and/or interference. They are realized in ring resonators; prism couplers; surface plasmon resonance; resonant mirror; Bragg grating; grating couplers; photonic crystals, Mach-Zehnder, Young, Hartman interferometers; backscattering; ellipsometry; or reflectance interferometry. The physical theories of various optical principles have already been reviewed in detail elsewhere and are therefore only cited. This review provides an overall survey on the application of these methods in direct optical biosensing. The "historical" development of the main principles is given to understand the various, and sometimes only slightly modified variations published as "new" methods or the use of a new acronym and commercialization by different companies. Improvement of optics is only one way to increase the quality of biosensors. Additional essential aspects are the surface modification of transducers, immobilization strategies, selection of recognition elements, the influence of non-specific interaction, selectivity, and sensitivity. Furthermore, papers use for reporting minimal amounts of detectable analyte terms such as value of mass, moles, grams, or mol/L which are difficult to compare. Both these essential aspects (i.e., biochemistry and the presentation of LOD values) can be discussed only in brief (but references are provided) in order to prevent the paper from becoming too long. The review will concentrate on a comparison of the optical methods, their application, and the resulting bioanalytical quality.

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Section: Fibers and Waveguides Without Structurementioning

confidence: 99%

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Gauglitz

2020

Anal Bioanal Chem

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“…The presence of an analyte and its concentration is identified based on the interference pattern, reproduced from Ref. 14 24 demonstrated simultaneous detection of two DNA oligonucleotides. Isolating 8 of the resonators to use as control sensors, they separated the remaining 24 sensors into two groups and functionalized each for a specific oligonucleotide and successfully demonstrated multiplexed sensing.…”

Section: Ring-resonator Sensorsmentioning

confidence: 99%

Photonic integrated circuits for Department of Defense-relevant chemical and biological sensing applications: state-of-the-art and future outlooks

et al. 2019

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Photonic integrated circuits (PICs), the optical counterpart of traditional electronic integrated circuits, are paving the way toward truly portable and highly accurate biochemical sensors for Department of Defense (DoD)-relevant applications. We introduce the fundamentals of PIC-based biochemical sensing and describe common PIC sensor architectures developed to-date for single-identification and spectroscopic sensor classes. We discuss DoD investments in PIC research and summarize current challenges. We also provide future research directions likely required to realize widespread application of PIC-based biochemical sensors. These research directions include materials research to optimize sensor components for multiplexed sensing; engineering improvements to enhance the practicality of PIC-based devices for field use; and the use of synthetic biology techniques to design new selective receptors for chemical and biological agents. © The Authors.Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…Most bio-sensors are developed on silicon-on-insulator (SOI) substrates due to the high refractive index contrast between silicon device layers and buried oxide layers. Silicon is highly transparent in the infrared wavelength region of light, and therefore, silicon photonics has emerged as a promising solution for the development of opto-fluidic biosensors operating at the infrared wavelength region of light [1,2]. Low-loss photonic-integrated nanowires are developed on SOI substrates [3].…”

Section: Introductionmentioning

confidence: 99%

Modeling and Analysis of SOI Gratings-Based Opto-Fluidic Biosensor for Lab-on-a-Chip Applications

Muniswamy¹,

Pattnaik

Krishnaswamy³

2019

Photonics

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† This paper is an extended version of our paper published in: Venkatesha, M.; Vismaya, K.R.; Prashanth, A.U.; Vyshnavi, M.; Narayan, K. Modeling and Analysis of SOI Grating Coupler for Bio-sensing Applications.Abstract: The design, modeling, and analysis of a silicon-on-insulator (SOI) grating coupler integrated with a microfluidic channel for lab-on-a-chip applications are presented. The grating coupler was designed to operate at 1310 nm. The simulated SOI structure consisted of a 220 nm top-Si device layer with an integrated waveguide, grating coupler, and a buried oxide layer of 2 µm. A rectangular microfluidic channel was deposited on the SOI optical grating structure for light and fluid interaction. The fluidic flow through the device was driven by centrifugal and Coriolis forces. The grating structure was designed to achieve a maximum coupling efficiency at the optimized injection angle of the light source. The sensitivity of the grating structure could be analyzed and evaluated using the change in coupled power as a function of the effective refractive index and was found to be 0.928 × 10 −6 RIU. The SOI optical grating structure along with the micro fluidic channel on top could be effectively used as an absorbance-based lab-on-a-chip biosensor.Photonics 2019, 6, 71 2 of 9 changes in physical parameters such as temperature, pressure, and magnetic field [17][18][19][20][21]. The Bragg wavelength for optical sensing applications is given by Equation (1) [22]:

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Silicon Photonic Biosensors Using Label-Free Detection

Cited by 292 publications

References 268 publications

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects

Photonic integrated circuits for Department of Defense-relevant chemical and biological sensing applications: state-of-the-art and future outlooks

Modeling and Analysis of SOI Gratings-Based Opto-Fluidic Biosensor for Lab-on-a-Chip Applications

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