Silicon Photonics Sensors for Biophotonic Applications—A Review

Dhote, Chandresh; Singh, Anamika; Kumar, Santosh

doi:10.1109/jsen.2022.3199663

Cited by 38 publications

(10 citation statements)

References 79 publications

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“…Fabry-Perot interferometers [101,102] and photonic crystal (PC) cavities [103] have been also used as photonic biosensors. Fabry-Perot cavities operate based on multi-beam interferences of electromagnetic waves passed through two highly reflective spaced surfaces.…”

Section: B Optical Biosensorsmentioning

confidence: 99%

“…Additionally, photonic crystals are multidimensional dielectric cavities that can detect a variety of biological elements for disease diagnosis. Periodic patterns of these structures in one, two, or three directions affect wave propagation by forming photonic bandgaps [103]. Meanwhile, a local defect in their periodic structure results in occurring a sharp resonance peak within the bandgap spectrum, which can offer a highly precise detection mechanism for monitoring biomarkers through strongly confined resonances.…”

Section: B Optical Biosensorsmentioning

confidence: 99%

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Alzheimer's Disease Diagnosis in the Preclinical Stage: Normal Aging or Dementia

Marvi,

Chen,

Sawan

2024

IEEE Rev. Biomed. Eng.

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Alzheimer's disease (AD) progressively impairs the memory and thinking skills of patients, resulting in a significant global economic and social burden each year. However, diagnosis of this neurodegenerative disorder can be challenging, particularly in the early stages of developing cognitive decline. Current clinical techniques are expensive, laborious, and invasive, which hinders comprehensive studies on Alzheimer's biomarkers and the development of efficient devices for Point-of-Care testing (POCT) applications. To address these limitations, researchers have been investigating various biosensing techniques. Unfortunately, these methods have not been commercialized due to several drawbacks, such as low efficiency, reproducibility, and the lack of accurate identification of AD markers. In this review, we present diverse promising hallmarks of Alzheimer's disease identified in various biofluids and body behaviors. Additionally, we thoroughly discuss different biosensing mechanisms and the associated challenges in disease diagnosis. In each context, we highlight the potential of realizing new biosensors to study various features of the disease, facilitating its early diagnosis in POCT. This comprehensive study, focusing on recent efforts for different aspects of the disease and representing promising opportunities, aims to conduct the future trend toward developing a new generation of compact multipurpose devices that can address the challenges in the early detection of AD.

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Section: B Optical Biosensorsmentioning

confidence: 99%

Section: B Optical Biosensorsmentioning

confidence: 99%

Alzheimer's Disease Diagnosis in the Preclinical Stage: Normal Aging or Dementia

Marvi,

Chen,

Sawan

2024

IEEE Rev. Biomed. Eng.

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“…These devices are regarded as the most viable technological platform for implementing photonics-integrated circuits (PICs) for optical interconnects, biosensing, and data processing [ 48 ]. In areas including fundamental medical research and diagnosis, smart home healthcare diagnostics, and gas sensing applications, Si photonic sensors have been extensively studied for usage as biosensors, temperature sensors, and gas sensors [ 56 ]. These sensors should have high sensitivity, which is strongly affected by the size of the device, optical loss, the polarization of the light, and the overlap between the light and the surrounding material.…”

Section: Rr Sensors Based On Different Platforms and Potential Applic...mentioning

confidence: 99%

A Review of Photonic Sensors Based on Ring Resonator Structures: Three Widely Used Platforms and Implications of Sensing Applications

2023

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Optical ring resonators (RRs) are a novel sensing device that has recently been developed for several sensing applications. In this review, RR structures based on three widely explored platforms, namely silicon-on-insulator (SOI), polymers, and plasmonics, are reviewed. The adaptability of these platforms allows for compatibility with different fabrication processes and integration with other photonic components, providing flexibility in designing and implementing various photonic devices and systems. Optical RRs are typically small, making them suitable for integration into compact photonic circuits. Their compactness allows for high device density and integration with other optical components, enabling complex and multifunctional photonic systems. RR devices realized on the plasmonic platform are highly attractive, as they offer extremely high sensitivity and a small footprint. However, the biggest challenge to overcome is the high fabrication demand related to such nanoscale devices, which limits their commercialization.

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“…An evanescent field results from some of the light radiating into the cladding after it passes through the waveguide's core. The optical characteristics of this evanescent field are influenced by the concentration of the bio sample resulting in measurement of glucose concentration 1,5 . In this proposed work measured concentration of glucose in sample based on RI change of biosensor.…”

Section: Introductionmentioning

confidence: 99%

Four layer integrated optical biosensor

Manchikalapati,

VL,

Talabattula

2024

SPIE Advanced Biophotonics Conference (SPIE ABC 2023)

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Integrated optical biosensors are capable of combining properties of miniaturization, stability and high sensitivity. In this paper a novel integrated optic biosensor for the measurement of glucose concentration in the blood design is proposed and analysed mathematically. The configuration is based on silicon on insulator technology and consists of four layers, the oxide substrate layer, thin silicon nitride layer to enhance the sensitivity, the silicon ridge waveguide optical guiding layer, and the cover layer consisting of bio-analyte to be measured. The main idea in this configuration is the introduction of thin nitride layer in between silicon and silicon dioxide. Then it was observed that in the case of three layer waveguide the mode penetration into the cladding influences the sensitivity. Introduction of silicon nitride layer between the oxide and guiding layer reduces the refractive index contrast between the substrate and the guiding layer resulting in increased penetration depth we obtain a sensitivity of 1%, in terms of effective refractive index change.

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Silicon Photonics Sensors for Biophotonic Applications—A Review

Cited by 38 publications

References 79 publications

Alzheimer's Disease Diagnosis in the Preclinical Stage: Normal Aging or Dementia

Alzheimer's Disease Diagnosis in the Preclinical Stage: Normal Aging or Dementia

A Review of Photonic Sensors Based on Ring Resonator Structures: Three Widely Used Platforms and Implications of Sensing Applications

Four layer integrated optical biosensor

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