Silicon Quantum Dots: Promising Theranostic Probes for the Future

Sivasankarapillai, Vishnu Sankar; Jose, Jobin; Shanavas, Muhammad Salman; Marathakam, Akash; Uddin, Sahab; Mathew, Bijo

doi:10.2174/1389450120666190405152315

Cited by 36 publications

(16 citation statements)

References 74 publications

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“…Concern over QD cytotoxicity has been an important research topic over the last few decades, and various methods have been reported to reduce the toxicity of QD during their preparation. Silicon QDs are a family of well-studied QDs owing to their excellent biocompatibility and tunable physical and chemical properties, making them good candidates for theranostic applications (Sivasankarapillai et al 2019). However, when we search through the literature focusing on the cytotoxic properties of all types of QDs, the diverse nature of the individual QD systems makes comparison difficult.…”

Section: Decreasing the Toxicity Of Qds In Biomedical Applicationsmentioning

confidence: 99%

Revisiting the cytotoxicity of quantum dots: an in-depth overview

et al. 2020

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Recently, medical research has been shifting its focus to nanomedicine and nanotherapeutics in the pursuit of drug development research. Quantum dots (QDs) are a critical class of nanomaterials due to their unique properties, which include optical, electronic, and engineered biocompatibility in physiological environments. These properties have made QDs an attractive biomedical resource such that they have found application as both in vitro labeling and in vivo theranostic (therapydiagnostic) agents. Considerable research has been conducted exploring the suitability of QDs in theranostic applications, but the cytotoxicity of QDs remains an obstacle. Several types of QDs have been investigated over the past decades, which may be suitable for use in biomedical applications if the barrier of cytotoxicity can be resolved. This review attempts to report and analyze the cytotoxicity of the major QDs along with relevant related aspects.

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Section: Decreasing the Toxicity Of Qds In Biomedical Applicationsmentioning

confidence: 99%

Revisiting the cytotoxicity of quantum dots: an in-depth overview

et al. 2020

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“…Thus the antimicrobial and antiviral properties of nanoparticles which are widely reported in scientific literature become a matter of urgent attention in this regard. Many categories of nanomaterials including quantum dots [ 20 ], nanotubes [ 21 ], metal oxide nanoparticles [ 22 ], polymer nanocomposites [ 23 ], two dimensional nanomaterials [ 24 ], lipid nanoparticles [ 25 ] etc, reported for their good antimicrobial activities thus came into the platform of COVID-19 management.…”

Section: Role Of Nanotechnology In the Management Of Viral Diseasesmentioning

confidence: 99%

Role of nanotechnology in facing SARS-CoV-2 pandemic: Solving crux of the matter with a hopeful arrow in the quiver

Sivasankarapillai¹,

Madaswamy²,

Dhanusuraman³

2021

Sensors International

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“…Although inorganic NPs are widely researched in clinical and preclinical settings in the identification, diagnosis, and treatment of various diseases they still raise issues about their effective medical applications regarding factors such as bio-compatibility and specificity. To resolve this, research teams are focusing on inorganic functionalization of the nanoparticles with different kinds of biocompatible constituents thus providing promising benefits of organic as well as inorganic nanoparticles [71]. Gold nanoparticles, being an inorganic nanoparticle offer a great advantage in the treatment of COVID-19.…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

State-of-the-Art Nanotechnology Based Drug Delivery Strategies to Combat Covid-19

et al. 2021

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The emerging Coronavirus Disease-19 (COVID-19) pandemic has had a global impact on all important aspects of our society. As it is known, SARS-Cov-2 can withstand up to 72 h in adverse environmental conditions, which can aid its rapid spread. Woefully, an efficacious and approbated vaccine for the SARS-CoV-2 virus remains unavailable, which makes the problem more frightening and presently more complicated bestowing forlorn medical care. Nevertheless, global clinical research is studying several over-the-counter (OTC) drugs approved for other indications to confront coronavirus. Over the past decade, therapeutic nanoparticles have been regarded as a felicitous tool for the efficient and persnickety delivery of therapeutic groups (i.e., drugs, vaccines, siRNAs, and peptides) to the site of infection. They can adequately convey the drug encapsulated nanoparticle to a designated locus without instigating unsought effects. Besides, they acquiesce the use of non-invasive imaging methods to monitor the surface of the infection and the response to treatment. The formulated nanoparticle is apposite for intranasal drug delivery which is a meritorious method to deliver therapeutic moiety for viral diseases affecting the lungs. Applying nanoparticles via intranasal route surmounted several demerits of mucosal administration like circumventing enzymatic degradation of the therapeutic moiety, upgrading and prolonging the action of the drug, etc., and can thus corroborate as an exceptional strategy to encounter respiratory viruses like coronavirus. In this article, we illuminate the promising role of nanoparticles as effective carriers of therapeutic or immunomodulatory agents to help combat COVID-19. The search criteria used were Pubmed, Medscape, Google scholar, etc and the keywords are coronavirus, nanoformulations, nanoparticles, drug delivery, intranasal delivery, etc. The articles range from 2012 to 2020.

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Silicon Quantum Dots: Promising Theranostic Probes for the Future

Cited by 36 publications

References 74 publications

Revisiting the cytotoxicity of quantum dots: an in-depth overview

Revisiting the cytotoxicity of quantum dots: an in-depth overview

Role of nanotechnology in facing SARS-CoV-2 pandemic: Solving crux of the matter with a hopeful arrow in the quiver

State-of-the-Art Nanotechnology Based Drug Delivery Strategies to Combat Covid-19

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