Silicon-zinc-glycerol hydrogel, a potential immunotropic agent for topical application

Хонина, Т. Г.; Иваненко, М. В.; Чупахин, О. Н.; Сафронов, А. П.; Богданова, Е. А.; Карабаналов, М. С.; Permikin, V. V.; Ларионов, Л. П.; Дроздова, Л. И.

doi:10.1016/j.ejps.2017.07.012

Cited by 14 publications

(3 citation statements)

References 25 publications

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“…They are used as biocompatible precursors in the sol–gel synthesis of pharmacologically active hydrogels with reparative, regenerative, antioxidant, immunotropic and antimicrobial effects. 8–10 In this regard, glycerolate of the biogenic iron element can be considered as an innovative biocompatible precursor in the sol–gel synthesis of composite bioactive hydrogels possessing a haemostatic effect characteristic of various iron compounds. 11…”

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confidence: 99%

Individual iron(iii) glycerolate: synthesis and characterisation

et al. 2022

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Individual iron(iii) glycerolate: synthesis and characterisation

et al. 2022

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“…That is why the immunological effect of immunomodulatory substances depends on the initial body immunity status: these substances reduce elevated and, conversely, increase decreased immunity indicators (Sepiashvili, 2015). Meanwhile, immunostimulants enhance immune responses, bringing reduced indicators to normal values, and immunosuppressants, on the contrary, suppress the body's immune response (Khonina et al, 2017;Arefieva et al, 2018).…”

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confidence: 99%

Features of the functioning of the natural defense mechanisms of piglets under the influence of immunotropic substances

Masiuk,

Nedzvetsky,

Kokariev

2023

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The number of studies related to detailed characteristics of immune system development in early stages of ontogenesis are directed to expansion of concepts of mechanisms of inherent and adaptive immunity in premature newborns. However, discrepancy in publication data and absence of clear conceptions about unique features of immune system in newborn piglets for different gestation periods have significant actuality for further investigation. The study was carried out to establish characteristics of phenotypic and functional characteristics of the immune cells and establishment of adaptive immunity in piglets. The antibody repertoire of sow has interested immunologists for decades, in part because of the ease with which large quantities of high affinity antibodies can be observed in serum, and into other fluids because of the presence of genetic variants for both light and heavy chain of all known immunoglobulin types. The integrative analysis of the cellular and humoral immunity in piglets during early ontogenesis carried out to clarify the exact mechanisms of the immune response modulation. Effectiveness and selectivity of the immunotropic chemicals application to regulate immune cell populations in piglets is presented. The progress in immune cell populations is regulated by the various cytokines production in the universal concentration-dependent manner. Furthermore, the development of the immune functions cross reacts with innate immunity mechanisms including anti-bacterial enzymes, epithelial barrier integrity in the both skin and intestine. The interaction between multiple components of innate immunity is a critic initiator of the dynamic changes in adaptive immunity. The natural resistance targets to the establishment of infection root and delays disease progression. The duration of the exposure to colostrum in important role in the dynamics of immune response as well as its efficacy. The chapter discusses the plural mechanisms so far proposed to be responsible for the modulation natural resistance.

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“…И.Я. Постовского УрО РАН был синтезирован с использованием золь-гель метода целый ряд фармакологически активных элементсодержащих гидрогелей, в том числе, нанокомпозитных, на основе полиолатов кремния, титана, цинка, борав качестве биосовместимых прекурсоров [1][2][3][4][5]. Были установлены общие закономерности и выявлены особенности зольгель процесса для каждого типа прекурсоров.…”

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