With the growing population, rising burden of disease and disability, there is an increase in demands for quality care and accessibility to medical devices and materials used in the manufacturing of these medical devices. However, not all materials can be used for this purpose. The biomaterials that can be used have specific properties and characteristics before they can be used to design health solutions and devices. To choose biomaterials for a particular purpose and manufacture medical devices, the first step is to determine the proper material that will serve the desired goal, the way it will be utilized and its capacity to fulfil the role. This review focuses on biomaterials, their types, uses, desired properties and pros and cons of every kind of biomaterial available. The review takes a deep dive into the five major types of synthetic biomaterials biocompatible polymers, natural biocompatible polymers, biocompatible metals, biocompatible ceramics, and biocompatible composites. It is also an indepth look into how these materials are regulated, how their authenticity is tested and what new directions the biomaterials research is taking.