Silicone granulomas: Report of three cases and review of the literature

Travis, William D.; Balogh, Károly; Abraham, Jerrold L.

doi:10.1016/s0046-8177(85)80209-4

Cited by 220 publications

(83 citation statements)

References 79 publications

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“…24 However, some case reports have attributed various immunological side effects to the use of silicone, such as localized and distant granulomatous inflammation in the breast, reactive lymphadenopathy, inflammation of joint capsules following erosion or fracture of a prosthesis, endocarditis, nephropathy, hepatic granulomas and fibrosis, respiratory distress syndrome and human adjuvant disease, indicating that silicone is not inert and can, in fact, provoke a local or systemic immune response. [25][26][27][28][29][30] Furthermore, silicone gel-protein mixtures have been used as potent immunological adjuvants. 31 In support of this, evidence from animal studies suggests that silicone gel is immunogenic 32 and can induce plasmacytomas in genetically predisposed mice.…”

Section: Discussionmentioning

confidence: 99%

Seroma-associated primary anaplastic large-cell lymphoma adjacent to breast implants: an indolent T-cell lymphoproliferative disorder

et al. 2008

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Non-Hodgkin lymphomas of the breast are rare, encompassing approximately 0.04-0.5% of all malignant breast tumors, and the vast majority are B-cell lymphomas. In contrast, lymphomas of T-cell phenotype have been rarely reported and some of these have been in close proximity to a breast implant. In our consultation practice, we have identified four patients with primary T-cell anaplastic large-cell lymphoma presenting adjacent to silicone or saline breast implants. All patients presented with seroma and neoplastic cells were identified in suspension in the serous fluid without solid tissue invasion. Three patients had no evidence of systemic disease (stage 1E), and one patient was not staged. The mean age of the patients was 46 years (range, 34-59 years). In all patients, the neoplastic cells had a T-cell phenotype, expressed CD30, cytotoxic granuleassociated proteins, EMA and clusterin, and were anaplastic lymphoma kinase-1-negative. Clonal T-cell receptor c-chain gene rearrangements were identified in three patients. All patients underwent capsulectomy with removal of the implant. One patient subsequently received chemotherapy and radiation therapy, and another was treated with radiation alone. The third patient received no further therapy and the fourth patient has been recently diagnosed. After a mean time of 13 months (range, 9-20 months), all three patients with follow-up were alive and well without any recurrence or systemic disease. Although the follow-up time was relatively short, our series and other reported cases suggest that primary anaplastic large-cell lymphoma adjacent to breast implants is an indolent T-cell lymphoproliferative disorder. Keywords: anaplastic large-cell lymphoma; primary lymphoma of breast; breast implant; silicone; saline Non-Hodgkin lymphomas of the breast are rare and comprise approximately 0.04-0.5% of all malignant breast tumors and 2.2% of extranodal lymphomas.

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Section: Discussionmentioning

confidence: 99%

Seroma-associated primary anaplastic large-cell lymphoma adjacent to breast implants: an indolent T-cell lymphoproliferative disorder

et al. 2008

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“…The cystic spaces are relatively small and uniform. Calcifications are in the form of irregular microcalcifications, and small ring-like or large eggshell calcifications (13)(14)(15). These histologic findings of foreign body granulomas induced by liquid silicone might be confused with those of paraffinoma.…”

Section: B Amentioning

confidence: 99%

CT features of foreign body granulomas after cosmetic paraffin injection in the cervicofacial area

Yoon²,

Chang³

et al. 2009

Diagn Interv Radiol

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“…İnsülinin enjektöre çekilmesinden sonra enjektör içinde kalan havanın dışarı çıkması amacıyla pistonun ileri geri hareketinin minimal sayıda olması gerekliliği üzeinde durulmuştur. 17 …”

Section: Discussionunclassified

İntravitreal Enjeksiyon Sonrasında Vitreus İçinde Gözlenen Silikon Yağı Damlacıklı Olgulara Yaklaşımımız

Rasier¹,

Şenel

Artunay

et al. 2012

tjo

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ÖzetAmaç: İntravitreal enjeksiyon tedavisi gören hastaların takiplerinde enjeksiyon sonrası vitreus içi silikon yağı damlacıklarının komplikasyon olarak görülebildiğini ve bu hastalara yaklaşımımızı açıklamak. Ge reç ve Yön tem: T.C. İstanbul Bilim Üniversitesi Göz Kliniği'ne Aralık 2010 -Şubat 2011 tarihleri arasında intravitreal enjeksiyon tedavisi gören 4 hasta gözün önünde uçuşan cisim yakınmasıyla, 2 hasta da enjeksiyon sonrası rutin kontrol muayenesi için başvurdu. Sonuçlar: Yapılan oftalmolojik muayenede fundus bakısında vitreus içinde serbest silikon yağı damlacıkları gözlendi. Bevacizumab enjeksiyonu yapılmış hastalardan %0,04'ünde intravitreal silikon yağı damlacığına rastlanılmışken ranibizumab enjeksiyonu yapılmış hastaların hiçbirinde bu bulguya rastlanılmadı. Vitreus içi silikon yağı damlacığı görülmesinden önce ortalama enjeksiyon sayısı 4,8 (3-8) olup, hastaların almış oldukları toplam enjeksiyon sayısı ortalaması 6,8 (3-9)'dır. Toplam 6 hastanın 2 tanesi asemptomatik, 4 tanesi semptomatikti. Semptomatik olan 2 hastanın vitreuslarında gözlenen silikon yağı damlacıları optik aks üzerinde bulunduğu için pars plana vitrektomi yöntemiyle çıkarıldı. Vitreus ekstraktlarının patolojik incelenmesinde görülen damlacıkların silikon yağı olduğu doğrulandı. Tar t›fl ma: Çalışmamızda intravitreal bevacizumab enjeksiyonlarında kullanılan enjektör ekipmanının vitreus içi silikon yağı damlacığı komplikasyonunu beraberinde getirebildiği saptanmış olup bu durumun ekipman değişimi ile önlenebileceği görülmüştür. Sum maryPur po se: To demonstrate that post-injection intravitreal silicone oil droplets can be seen as a complication in the follow-up of patients who had undergone intravitreal injection treatment and to discuss our clinical approach to these patients. Ma te ri al and Met hod: Out of 6 patients who had undergone intravitreal injection treatment in T. C. Istanbul Bilim University Ophthalmology Clinic between December 2010 and February 2011, four presented with complaints of floaters and 2 patients applied for followup after intravitreal injection. Re sults: On ophthalmological examination, free silicone oil droplets in the vitreous cavity were observed at fundoscopy. In 0.04% of patients who had undergone bevacizumab injections, intravitreal silicone oil droplets were seen, whereas no oil droplets were seen in patients who had undergone ranibizumab injections. Before silicone oil droplets were seen in the vitreous, the mean number of injections was 4.8 (3-8) and the mean number of the total injections that the patients have undergone was 6.8 (3-9). Two of the 6 patients were asymptomatic and 4 of them were symptomatic. The silicone oil droplets in the vitreous which were on the optical axis were extracted with pars plana vitrectomy method in two symptomatic patients. Pathological examination of the vitreous extracts confirmed that the observed droplets were silicone oil. Dis cus si on: In our study, it was determined that the injector equipment which is used in bevacizumab injections can bring along the c...

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Silicone granulomas: Report of three cases and review of the literature

Cited by 220 publications

References 79 publications

Seroma-associated primary anaplastic large-cell lymphoma adjacent to breast implants: an indolent T-cell lymphoproliferative disorder

Seroma-associated primary anaplastic large-cell lymphoma adjacent to breast implants: an indolent T-cell lymphoproliferative disorder

CT features of foreign body granulomas after cosmetic paraffin injection in the cervicofacial area

İntravitreal Enjeksiyon Sonrasında Vitreus İçinde Gözlenen Silikon Yağı Damlacıklı Olgulara Yaklaşımımız

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