Silicones Today

Willoughby, Julie A.

doi:10.1007/s12633-011-9101-z

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…A second trend has emerged to yield hybrids of peptide and synthetic polymer, mainly with poly(ethylene glycol) and either (meth)acrylic chains11 or with silica matrixes 12–14. On the other hand, silicones, also referred as polysiloxanes, have a long track record as industrial biocompatible, bioinert, and biodurable materials 15. Silicones have been widely used since the 60s in medicine as orthopedics, catheters, drains, shunts, extra corporeal equipments, implants, and as injectable fluids for soft‐tissue augmentation 16.…”

Section: Methodsmentioning

confidence: 99%

A New Way to Silicone‐Based Peptide Polymers

et al. 2015

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Section: Methodsmentioning

confidence: 99%

A New Way to Silicone‐Based Peptide Polymers

et al. 2015

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“…Polysiloxanes, well known as ‘silicones’, are biocompatible, bio‐inert, and biodurable materials extensively used since the 1960s in medicine especially as medical device components for the fabrication of catheters, drains, shunts, orthopedics, and implants and also as injectable fluids for reconstructive surgery . Despite their outstanding properties such as resistance to temperature and chemicals, high flexibility and elasticity, there is still a need for functional silicones whose properties can be adjusted by the addition of a bioorganic moiety.…”

Section: Introductionmentioning

confidence: 99%

Turning peptides in comb silicone polymers

Jebors

Pinese

Nottelet

et al. 2015

Journal of Peptide Science

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We have recently reported on a new class of silicone-peptide' biopolymers obtained by polymerization of di-functionalized chlorodimethylsilyl hybrid peptides. Herein, we describe a related strategy based on dichloromethylsilane-derived peptides, which yield novel polymers with a polysiloxane backbone, comparable with a silicone-bearing pendent peptide chains. Interestingly, polymerization is chemoselective toward amino acids side-chains and proceeds in a single step in very mild conditions (neutral pH, water, and room temperature). As potential application, a cationic sequence was polymerized and used for antibacterial coating.

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“…[12][13][14] On the other hand, silicones, also referred as polysiloxanes, have a long track record as industrial biocompatible, bioinert, and biodurable materials. [15] Silicones have been widely used since the 60s in medicine as orthopedics, catheters, drains, shunts, extra corporeal equipments, implants, and as injectable fluids for soft-tissue augmentation. [16] However, these last properties are not sufficient for the more demanding tissueengineering applications where additional bioactivity is required.…”

mentioning

confidence: 99%