Silicosis and Smoking Strongly Increase Lung Cancer Risk in Silica-Exposed Workers

Kurihara, Nobutaka; Wada, Osamu

doi:10.2486/indhealth.42.303

Cited by 79 publications

(60 citation statements)

References 58 publications

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“…Personal and occupational data of all miners in both cohorts was merged with the data from the National Population Register (date and diagnosis of death) and the Czech National Cancer Registry (date and diagnosis of disease) for the period from 1992 to 2006. Cancer risk of miners from both cohorts in comparison to the general male population of the Czech Republic was evaluated by SIR (Standardized Incidence Ratio) silica [5][6][7]. Based on the evidence, IARC classified crystalline silica as a carcinogen belonging to group I [8][9].…”

Section: Methodsmentioning

confidence: 99%

Cancer incidence in Czech black coal miners in association with coalworkers’ pneumoconiosis

Tomášková¹,

Jirák²,

Šplíchalová³

et al. 2012

International Journal of Occupational Medicine and Environmental Health

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Objective: The aim of the study was comparison of cancer incidence risk of lungs, stomach, colon, bladder and kidneys from ex-miners of black coal mines and the general male population of the Czech Republic. Materials and methods: The analysis was conducted in two cohorts of ex-miners according to the presence of coalworkers' pneumoconiosis (CWP). The first cohort included the miners without CWP (N = 6705), and the second cohort included the miners who were compensated for CWP (N = 2158). Personal and occupational data was merged with the data in the National Population Register and the National Oncological Register for the period from 1992 to 2006. Cancer risk in miners in comparison to the general male population of the Czech Republic was evaluated by SIR (Standardized Incidence Ratio) and 95% confidence interval (CI). Results: About twice as high risk of lung cancer was found in miners with CWP (SIR = 2.21; 95% CI: 1.75-2.76). Lung cancer risk correlated with the severity of CWP (simple CWP SIR=1.96; 95% CI: 1.48-2.56, progressive massive fibrosis SIR = 4.29; 95% CI: 2.09-7.87). No increased risk of lung cancer was found in ex-miners without CWP. The risk of malignant neoplasm at the other selected sites was comparable with the risk in the general male population of the Czech Republic. Conclusions: This study found increased lung cancer risk in coal miners with CWP, but not in those without CWP, comparing with the general population. These results served as the basis for the inclusion of lung cancer in association with CWP into a new Czech list of occupational diseases.

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Section: Methodsmentioning

confidence: 99%

Cancer incidence in Czech black coal miners in association with coalworkers’ pneumoconiosis

Tomášková¹,

Jirák²,

Šplíchalová³

et al. 2012

International Journal of Occupational Medicine and Environmental Health

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“…Pneumoconiosis is an important occupational disease with potential fatal outcomes. Besides, it is also known that the frequency of tuberculosis and cancer is higher in pneumoconiosis cases as compared to the normal population [8][9][10][11]. Thus, it is necessary to make an early diagnosis, know the risk factors, and take preventive measures to decrease the mortality and morbidity rates of the disease.…”

Section: Introductionmentioning

confidence: 99%

Pneumoconiosis and respiratory problems in dental laboratory technicians: Analysis of 893 dental technicians

Ergün¹,

Ergün²,

Özdemir³

et al. 2014

IJOMEH

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Objectives: To explore the rate of pneumoconiosis in dental technicians (DTP) and to evaluate the risk factors. Material and Methods: Data of 893 dental technicians, who were admitted to our hospital in the period January 2007-May 2012, from 170 dental laboratories were retrospectively examined. Demographic data, respiratory symptoms, smoking status, work duration, working fields, exposure to sandblasting, physical examination findings, chest radiographs, pulmonary function tests and high-resolution computed tomography results were evaluated. Results: Dental technicians' pneumoconiosis rate was 10.1% among 893 cases. The disease was more common among males and in those exposed to sandblasting who had 77-fold higher risk of DTP. The highest profusion subcategory was 3/+ (according to the International Labour Organization (ILO) 2011 standards) and the large opacity rate was 13.3%. Conclusions: To the best of our knowledge, it was the largest DTP case series (N = 893/90) in the literature in English. Health screenings should be performed regularly for the early diagnosis of pneumoconiosis, which is an important occupational disease for dental technicians.

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“…In a recent review of global burden of disease due to occupational carcinogens, silica showed the highest proportion of workers exposed and the highest weighted relative risk (relative risk weighted by proportion exposed) for lung cancer among eight lung carcinogens tabulated (2). Several studies, including pooled analyses and meta-analyses, have reported an association between respirable silica and lung cancer (3)(4)(5)(6)(7)(8). Several cohort studies have reported relative risks of lung cancer of approximately 1.3 to 1.4 among silica-exposed workers, with significant and/or monotonic dose-response relationships (4,8).…”

Section: Introductionmentioning

confidence: 99%

Occupational Exposure to Silica and Lung Cancer: Pooled Analysis of Two Case-Control Studies in Montreal, Canada

Vida

Pintos²,

Parent³

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Respirable crystalline silica is a highly prevalent occupational exposure and a recognized lung carcinogen. Most previous studies have focused on selected high-exposure occupational groups. This study examines the relationship between occupational exposure to silica and lung cancer in an occupationally diverse male population.Methods: Two large population-based case-control studies of lung cancer were conducted in Montreal, one in 1979-1986 (857 cases, 533 population controls, 1,349 cancer controls) and the second in 1996-2001 (738 cases and 899 controls). Interviews provided descriptive lifetime job histories, smoking histories, and other information. Industrial hygienists translated job histories into histories of exposure to a host of occupational substances, including silica. Relative risk was estimated, adjusting for several potential confounders, including smoking.Results: The odds ratio for substantial exposure to silica was 1.67 (95% confidence interval, 1.21-2.31) and for any exposure was 1.31 (95% confidence interval, 1.08-1.59). Joint effects between silica and smoking were between additive and multiplicative, perhaps closer to the latter. In this population, it is estimated that approximately 3% of lung cancers were attributable to substantial silica exposure.Conclusions: The carcinogenicity of inhaled crystalline silica was observed in a population with a wide variety of exposure circumstances.Impact: The finding of carcinogenicity across a wide range of occupations complements prior studies of specific high-exposure occupations. This suggests that the burden of cancer induced by silica may be much greater than previously thought. Cancer Epidemiol Biomarkers Prev; 19(6); 1602-11. ©2010 AACR.

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Silicosis and Smoking Strongly Increase Lung Cancer Risk in Silica-Exposed Workers

Cited by 79 publications

References 58 publications

Cancer incidence in Czech black coal miners in association with coalworkers’ pneumoconiosis

Cancer incidence in Czech black coal miners in association with coalworkers’ pneumoconiosis

Pneumoconiosis and respiratory problems in dental laboratory technicians: Analysis of 893 dental technicians

Occupational Exposure to Silica and Lung Cancer: Pooled Analysis of Two Case-Control Studies in Montreal, Canada

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