Silicosis and urinary analysis

Altinoz, Hilal

doi:10.14744/scie.2018.07379

Cited by 1 publication

(2 citation statements)

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“…Several studies have reported that foundry work is associated with high levels of silica exposure, as sand is the major component used in the core and mold production process in foundry industry (Kuo et al, 2018).Also they linked long term silica exposure to renal diseases. Renal affection induced by silica exposure is represented by glomerular and tubulointerstitial nephropathies (Altınöz et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Edema on the other hand was statistically significantly higher among exposed workers compared to controls. Table (2) showed that there were statistically significant higher mean values of urinary silica, serum cystatin C, serum creatinine, serum urea, urinary α1microglobulin, urinary albumin and ACR; and a statistically significant lower mean value of the e-GFR among silica-exposed group compared to the non-exposed.…”

Section: Exposed Group No=70mentioning

confidence: 95%

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Kidney Affection Among Workers Exposed to Silica in an Iron and Steel Foundry

Hussein

Attia

Zayed

et al. 2023

Egypt. J. Occup. Med.

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Introduction: Silica is used in many industries such as foundries, glass production, cement, concrete, ceramic, porcelain, pottery, bricks, sandblasting, abrasives and construction activities. Several studies have linked long term silica exposure to renal diseases, especially glomerulonephritis. Aim of Work: To study the effect of silica exposure on the renal functions among iron and steel foundry workers. Materials and Methods: Seventy workers exposed to silica in an iron and steel foundry in Helwan, Egypt, were compared to 40 non-exposed individuals as regards full medical and occupational histories, full clinical examination and laboratory investigations including measurement of serum creatinine, serum cystatin C, serum urea, urinary silica, urinary albumin and urinary α1-microglobulin. Albumin creatinine ratio (ACR) and estimated glomerular filtration rate (e-GFR) were also calculated. Results: A statistically significant higher values of urinary silica, urinary albumin, urinary α1-microglobulin, serum creatinine, serum cystatin C and ACR were detected among the exposed group compared to the control. A statistically significant lower value of e-GFR was found among the exposed group. Statistically significant positive correlations were present between duration of employment and each of urinary silica, serum cystatin C, serum creatinine, serum urea, urinary α1-microglobulin, urinary albumin and ACR levels among the exposed group. Statistically significant positive correlations were also detected between urinary silica level and each of serum cystatin C, serum creatinine, serum urea, urinary α1-microglobulin, urinary albumin and ACR among the exposed group. Whereas, the e-GFR showed statistically significant negative correlations with both duration of employment and the urinary silica level among the exposed group. Conclusion and Recommendations: Silica exposure was associated with altered kidney function tests and decreased level of the e-GFR. Pre-employment and periodic medical examinations for silica-exposed workers should include clinical examination and determination of kidney functions, e-GFR, urinary α1-microglobulin and serum .cystatin C for early detection of kidney affection

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Section: Discussionmentioning

confidence: 99%

Section: Exposed Group No=70mentioning

confidence: 95%