Silicosis in Turkey: Is it an Endless Nightmare or is There Still Hope?

Akgün, Metin; Ergan, Begüm

doi:10.5152/turkthoracj.2018.040189

Cited by 74 publications

(11 citation statements)

References 35 publications

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“…Although mining and stone industry were traditional sources of silica exposure, new sources such as sand blasting in the denim industry raise the expected prevalence of silicosis to over 96% 3 , 19 . Unique characteristics of these patients include their young age, a definite start of exposure, an intense exposure for ca.…”

Section: Resultsmentioning

confidence: 99%

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STING-dependent sensing of self-DNA drives silica-induced lung inflammation

et al. 2018

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Silica particles induce lung inflammation and fibrosis. Here we show that stimulator of interferon genes (STING) is essential for silica-induced lung inflammation. In mice, silica induces lung cell death and self-dsDNA release in the bronchoalveolar space that activates STING pathway. Degradation of extracellular self-dsDNA by DNase I inhibits silica-induced STING activation and the downstream type I IFN response. Patients with silicosis have increased circulating dsDNA and CXCL10 in sputum, and patients with fibrotic interstitial lung disease display STING activation and CXCL10 in the lung. In vitro, while mitochondrial dsDNA is sensed by cGAS-STING in dendritic cells, in macrophages extracellular dsDNA activates STING independent of cGAS after silica exposure. These results reveal an essential function of STING-mediated self-dsDNA sensing after silica exposure, and identify DNase I as a potential therapy for silica-induced lung inflammation.

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Section: Resultsmentioning

confidence: 99%

“…Unique characteristics of these patients include their young age, a definite start of exposure, an intense exposure for ca. 4 ± 2 years, and a rapid progression of the disease, often fatal 3 , 19 . Here, we investigated a cohort of 21 young men suffering from silicosis after exposure to silica in denim industry in the mid-2000s (Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

et al. 2018

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“…After a 4‐year follow‐up period, nine (6.2%) had died with a mean age of just 24 years. Of the 74 living sandblasters available for re‐examination, the prevalence of silicosis increased from 53% to 96%, and radiographic progression was observed in 82% 45,79,80…”

Section: Epidemiology Of Silica‐associated Diseasesmentioning

confidence: 99%

Silica‐related diseases in the modern world

Hoy

Chambers

2020

Allergy

264

174

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Silicosis is an ancient and potentially fatal pneumoconiosis caused by exposure to respirable crystalline silica. Silicosis is historically a disease of miners; however, failure to recognize and control the risk associated with silica exposure in contemporary work practices such as sandblasting denim jeans and manufacturing of artificial stone benchtops has led to re‐emergence of silicosis around the world. This review outlines the mineralogy, epidemiology, clinical and radiological features of the various forms of silicosis and other silica‐associated diseases. Perspective is provided on the most recent studies shedding light on pathogenesis, including the central role of innate immune effector cells and subsequent inflammatory cascades in propagating pulmonary fibrosis and the extrapulmonary manifestations, which uniquely characterize this pneumoconiosis. Clinical conundrums in differential diagnosis, particularly between silicosis and sarcoidosis, are highlighted, as is the importance of obtaining a careful occupational history in the patient presenting with pulmonary infiltrates and/or fibrosis. While silicosis is a completely preventable disease, unfortunately workers around the world continue to be affected and experience progressive or even fatal disease. Although no treatments have been proven, opportunities to intervene to prevent progressive disease, founded in a thorough cellular and molecular understanding of the immunopathology of silicosis, are highlighted.

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“…Because of the absence of a definitive silicosis treatment, prevention of the disease is the main concern. To prevent the disease, regular close monitoring of the workplaces and routine screening of the workers are required, in addition to the establishment of effective workplace regulations (2). In this paper, we report two cases of rare complications of silica dust exposure.…”

Section: Introductionmentioning

confidence: 96%

Rare complications of silica dust exposure

Shalaby¹,

Kamel²,

Al-Halfawy³

et al. 2019

Erciyes Med J

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Crystalline silica inhalation causes silicosis, one of the ancient occupational lung diseases. It leads to an irreversible fibrotic response in the lung parenchyma and, consequently, causes diffuse interstitial lung disease. Asymptomatic to chronic irreversible forms are various presentations of silicosis, which has a high-risk predisposition to various comorbidities. We documented two cases of rare presentations of silica dust exposure alveolar silicoproteinosis and silicotuberculosis.

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Silicosis in Turkey: Is it an Endless Nightmare or is There Still Hope?

Cited by 74 publications

References 35 publications

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

Silica‐related diseases in the modern world

Rare complications of silica dust exposure

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