Silk fibroin as a novel coating material for controlled release of theophylline

Abstract

The aim of this study was to explore potential use of the silk fibroin (SF) as an aqueous coating material for theophylline tablets. We have examined the film forming and coating properties of heat-treated fibroin, SF solution having different amounts of polyethylene glycol (PEG) and 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide (EDC) cross-linked SF. Heat-treated SF material possessed a brittle structure, which resulted in poor film forming and coating properties. The optimum PEG amount in SF solution was determined as 17% (by weight) for an acceptable film forming and zero order release profile. EDC cross-linked SF has shown a very good film forming and coating property with a potential for sustaining the drug release from coated theophylline tablets. Dissolution data for coated theophylline tablets were analyzed using Ritger and Peppas equation to describe the mechanism of drug release. Drug release from the EDC coated tablets followed zero-order kinetics. Release rate constants were found to be 0.26, 0.19, 0.16% min K1 for single-coated, double coated, and triple coated tablets, respectively. These results clearly demonstrated that silk fibroin has high utility as a novel aqueous coating material for controlled release products. q

Isolation of polyphenols from the extracts of olive leaves (Olea europaea L.) by adsorption on silk fibroin

“…Silk fibroin is an edible protein polymer which has functional aminoacids in its structure, and it is preferred in many biotechnological applications such as drug delivery and tissue engineering [30][31][32]. Its hydrophobic character makes it favorable adsorbent used in adsorption studies [33].…”

Characterization of silk fibroin/hyaluronic acid polyelectrolyte complex (PEC) films

“…On the other hand, HA is a natural anionic polysaccharide that has been used in the formation of PECs. It is thought as an attractive building block for the production of novel biomaterials with potential applications in drug delivery [19][20][21][22] and tissue engineering [23]. The specific objective of this work was to characterize the films produced by complex formation between SF and HA.…”

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

“…Methanol treatment is a widely used process to induce β-sheet formation although it does not transform all molecular regions. Ethanol, EDC, glutaraldehyde, and genipin cause the transition from random coils to β-sheet configurations of the scaffolds and is dependant on the length of time exposed to the solvent as well as the solvent concentration [112][113][114][115][116]. Studies have shown that regenerated silk fibers can hold their initial tensile integrity for 21 days under immune deficient in vitro culture conditions [117].…”