Silk-Fibroin-Assisted Cathodic Electrolytic Deposition of Calcium Phosphate for Biomedical Applications

Abstract

The biological responses of artificial biomaterials are affected strongly by its interfacial topography, especially from nano-to microscale. The structure controllability is essential for the design and synthesis of novel biomedical materials. Herein, the effect of soluble silk fibroin (SF) on the cathodic electrolytic deposition (ELD) behavior of octacalcium phosphate (OCP) coating is studied. It is observed that the addition of soluble SF does not change the inorganic phase of the coating (OCP), but it has a remarkable effect on the microstructure of the deposited coating. As a result, the OCP/SF composite coating possessed a micro/nano multilevel structure is finely constructed on titanium implant by using ELD technology. Such OCP/SF composite coating significantly promotes preosteoblast cells adhesion, spreading and proliferation. In general, effects have been made to produce an in-depth understanding of protein incorporated ELD technology to extend its application in the biomedical field. It provides a promising strategy to design and synthesize biomaterials with specific biomimetic structures and functions.

Silk Biomaterials for Bone Tissue Engineering

“…[ 7–10 ] Among them, silk is a promising biomaterial candidate in BTE due to its remarkable mechanical properties, biocompatibility, biodegradability, low immunogenicity, and ease of fabrication. [ 11–16 ] Increasing studies strengthened the potential of silk‐based BTE materials in bone regeneration ( Figure 1 ). [ 17–21 ] Although several reviews have discussed silk materials in BTE, [ 17–25 ] recent studies revealed the remarkable development of silk BTE substrates with osteogenic capacities.…”

Electrochemical Reduction Of Macroiones As A Surface-Active Nanocoating And Nanocomposites

“…The widespread use of chitosan is to some extent difficult due to the production of this polysaccharide by using a high-tech method of deacetylation of a chitin biopolymer released from the protective coating of the external organs of various small living creatures, such as crabs, crayfish, fish, pupae, etc. [7][8][9][10].…”