Silk fibroin-based hemostatic powders with instant and robust adhesion performance for sutureless sealing of gastrointestinal defects

Geng, Aizhen; Luo, Yuting; Zheng, Min; Zheng, Jie; Zhu, Rui; Bai, Shumeng

doi:10.1039/d4tb00554f

J. Mater. Chem. B

2024

DOI: 10.1039/d4tb00554f

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Silk fibroin-based hemostatic powders with instant and robust adhesion performance for sutureless sealing of gastrointestinal defects

Aizhen Geng,

Yuting Luo,

Min Zheng

et al.

Abstract: Powder-based hemostatic technology has offered unprecedented opportunities in surgical sealing and repair of irregularly shaped and noncompressible wounds. Despite their routine use, existing clinical hemostatic powders are challenged either by...

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A Self-Gelling Powder Based on Polyacrylic Acid/Polyethyleneimine/Polyethylene Glycol for High-Performance Hemostasis and Antibacterial Activity

Li,

Zhong

et al. 2024

Polymers

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Powder-based hemostatic materials have offered unprecedented opportunities for the effective sealing and repair of irregularly shaped wounds and high-pressure, noncompressible arterial bleeding wounds caused by surgeries, traffic accidents, and wartime injuries. However, inadequate adhesion to bleeding wounds and poor hemostasis in biological tissues remains challenging. Herein, we report a self-gelling hemostatic powder based on polyacrylic acid/polyethyleneimine/polyethylene glycol (named PPG) for rapid hemostasis and effective antibacterial ability. When deposited on bleeding wounds, PPG powder can absorb interfacial liquid and rapidly swell into a physically cross-linked hydrogel in situ within 2 s to form a pressure-resistant physical barrier. Furthermore, the in vivo and in vitro results indicate that, as an effective sealant, the PPG powder possesses ease of use, excellent hemocompatibility, strong antibacterial abilities, and superior blood clotting abilities. The effective hemostatic sealing capability of the PPG powder is demonstrated in a variety of injury models in rats and rabbits. All of these factors show that, with its superior wound treatment abilities, PPG powder is a profound biomaterial for surgical applications.

show abstract

A Self-Gelling Powder Based on Polyacrylic Acid/Polyethyleneimine/Polyethylene Glycol for High-Performance Hemostasis and Antibacterial Activity

Li,

Zhong

et al. 2024

Polymers

View full text Add to dashboard Cite

show abstract

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Silk fibroin-based hemostatic powders with instant and robust adhesion performance for sutureless sealing of gastrointestinal defects

Abstract: Powder-based hemostatic technology has offered unprecedented opportunities in surgical sealing and repair of irregularly shaped and noncompressible wounds. Despite their routine use, existing clinical hemostatic powders are challenged either by...

Cited by 1 publication

References 71 publications

A Self-Gelling Powder Based on Polyacrylic Acid/Polyethyleneimine/Polyethylene Glycol for High-Performance Hemostasis and Antibacterial Activity

A Self-Gelling Powder Based on Polyacrylic Acid/Polyethyleneimine/Polyethylene Glycol for High-Performance Hemostasis and Antibacterial Activity

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