Silk fibroin/hyaluronic acid porous scaffold for dermal wound healing

Zhang, Qiang; Chen, Shu; You, Renchuan; Tariq, Zeeshan; Huang, Jingjing; Li, Mingzhong; Yan, Shuqin

doi:10.1007/s12221-017-1230-6

Cited by 30 publications

(14 citation statements)

References 24 publications

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“…The ester linkage contains the functional group CO joined via carbon to another oxygen atom. [ 49 ] Furthermore, the appearance of new peaks located at 3900 and 1925 cm −1 could be observed in the HA–SF/ZO composite fibers, but not in the other components, which represented the successful incorporation of ZO into HA–SF core–shell nanofibers.…”

Section: Resultsmentioning

confidence: 98%

Hyaluronic Acid (HA)‐Based Silk Fibroin/Zinc Oxide Core–Shell Electrospun Dressing for Burn Wound Management

Hadisi

Farokhi

Bakhsheshi‐Rad

et al. 2020

Macromolecular Bioscience

135

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Burn injuries represent a major life‐threatening event that impacts the quality of life of patients, and places enormous demands on the global healthcare systems. This study introduces the fabrication and characterization of a novel wound dressing made of core–shell hyaluronic acid–silk fibroin/zinc oxide (ZO) nanofibers for treatment of burn injuries. The core–shell configuration enables loading ZO—an antibacterial agent—in the core of nanofibers, which in return improves the sustained release of the drug and maintains its bioactivity. Successful formation of core–shell nanofibers and loading of zinc oxide are confirmed by transmission electron microscopy, Fourier‐transform infrared spectroscopy, and energy dispersive X‐ray. The antibacterial activity of the dressings are examined against Escherichia coli and Staphylococcus aureus and it is shown that addition of ZO improves the antibacterial property of the dressing in a dose‐dependent fashion. However, in vitro cytotoxicity studies show that high concentration of ZO (>3 wt%) is toxic to the cells. In vivo studies indicate that the wound dressings loaded with ZO (3 wt%) substantially improves the wound healing procedure and significantly reduces the inflammatory response at the wound site. Overall, the dressing introduced herein holds great promise for the management of burn injuries.

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Section: Resultsmentioning

confidence: 98%

Hyaluronic Acid (HA)‐Based Silk Fibroin/Zinc Oxide Core–Shell Electrospun Dressing for Burn Wound Management

Hadisi

Farokhi

Bakhsheshi‐Rad

et al. 2020

Macromolecular Bioscience

135

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“…Combining the properties of natural protein and polysaccharides can be a promising strategy to obtain bioactive materials with a controlled structure in the biomedical field [ 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 ]. In silk fibroin/hyaluronic acid scaffolds, increasing hyaluronic acid content significantly enhanced the water binding capacity and flexibility [ 140 ].…”

Section: Blendingmentioning

confidence: 99%

“…This was possible because of the hydrophobic interaction between curcumin and the crystalline domain of silk fibroin [ 144 ]. The silk fibroin/hyaluronic acid porous scaffolds have promise as a dermal substitute because results of Zhang et al in vitro studies showed that scaffolds could support the fibroblast cell adhesion and proliferation and showed good cytocompatibility [ 145 ]. The pore radius and porosity decreased with a decrease in the freezing temperature and increase in the hyaluronic acid ratio.…”

Section: Blendingmentioning

confidence: 99%

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How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Grabska-Zielińska

Sionkowska

2021

Materials

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This review supplies a report on fresh advances in the field of silk fibroin (SF) biopolymer and its blends with biopolymers as new biomaterials. The review also includes a subsection about silk fibroin mixtures with synthetic polymers. Silk fibroin is commonly used to receive biomaterials. However, the materials based on pure polymer present low mechanical parameters, and high enzymatic degradation rate. These properties can be problematic for tissue engineering applications. An increased interest in two- and three-component mixtures and chemically cross-linked materials has been observed due to their improved physico-chemical properties. These materials can be attractive and desirable for both academic, and, industrial attention because they expose improvements in properties required in the biomedical field. The structure, forms, methods of preparation, and some physico-chemical properties of silk fibroin are discussed in this review. Detailed examples are also given from scientific reports and practical experiments. The most common biopolymers: collagen (Coll), chitosan (CTS), alginate (AL), and hyaluronic acid (HA) are discussed as components of silk fibroin-based mixtures. Examples of binary and ternary mixtures, composites with the addition of magnetic particles, hydroxyapatite or titanium dioxide are also included and given. Additionally, the advantages and disadvantages of chemical, physical, and enzymatic cross-linking were demonstrated.

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“…The combination of silk fibroin with GAG can be a strategy to improve and modulate the brittleness of produced hydrogels [114]. Silk fibroin has been combined with GAGs, mainly HA [115][116][117], with or without other polysaccharides such as alginate [118,119] or chitosan [120], for applications in skin wound healing [116,119], vascular growth factor delivery [121] and cartilage tissue [122]. HA has been reported to improve mechanical properties of silk fibroin scaffolds partially by supporting silk fibroin transitions to β-sheet conformations [114,123], in a pH dependent complexation mechanism, and by leading to the formation of crystalline and non-crystalline phases [124].…”

Section: Silk Fibroinmentioning

confidence: 99%

Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

et al. 2020

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Glycosaminoglycans (GAG) are long, linear polysaccharides that display a wide range of relevant biological roles. Particularly, in the extracellular matrix (ECM) GAG specifically interact with other biological molecules, such as growth factors, protecting them from proteolysis or inhibiting factors. Additionally, ECM GAG are partially responsible for the mechanical stability of tissues due to their capacity to retain high amounts of water, enabling hydration of the ECM and rendering it resistant to compressive forces. In this review, the use of GAG for developing hydrogel networks with improved biological activity and/or mechanical properties is discussed. Greater focus is given to strategies involving the production of hydrogels that are composed of GAG alone or in combination with other materials. Additionally, approaches used to introduce GAG-inspired features in biomaterials of different sources will also be presented.

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Silk fibroin/hyaluronic acid porous scaffold for dermal wound healing

Cited by 30 publications

References 24 publications

Hyaluronic Acid (HA)‐Based Silk Fibroin/Zinc Oxide Core–Shell Electrospun Dressing for Burn Wound Management

Hyaluronic Acid (HA)‐Based Silk Fibroin/Zinc Oxide Core–Shell Electrospun Dressing for Burn Wound Management

How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

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