Silk fibroin hydrogels for biomedical applications

Zhang, Hui; Xu, Dongyu; Zhang, Yong; Li, Minli; Chai, Renjie

doi:10.1002/smmd.20220011

Cited by 47 publications

(32 citation statements)

References 169 publications

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“…The resulting multifunctional silk textiles possess high mechanical strength and toughness with solvent resistance, thermal conductivity, and electrical conductivity contributed by carbon nanotubes. This combination of functional materials and spinning/processing technology will result in silk textiles that can satisfy the expanding demands 72 …”

Section: Forms Of Silk‐based Materialsmentioning

confidence: 99%

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Silk‐based conductive materials for smart biointerfaces

2023

Smart Medicine

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Silk-based conductive materials are widely used in biointerface applications, such as artificial epidermal sensors, soft and implantable bioelectronics, and tissue/cell scaffolds. Such biointerface materials require coordinated physicochemical, biological, and mechanical properties to meet current practical needs and future sophisticated demands. However, it remains a challenge to formulate silk-based advanced materials with high electrical conductivity, good biocompatibility, mechanical robustness, and in some cases, tissue adhesion ability without compromising other physicochemical properties. In this review, we highlight recent progress in the development of functional conductive silk-based advanced materials with different morphologies. Then, we reviewed the advanced paradigms of these silk materials applied as wearable flexible sensors, implantable electronics, and tissue/cell engineering with perspectives on the application challenges. Silk-based conductive materials can serve as promising building blocks for biomedical devices in personalized healthcare and other fields of bioengineering.

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Section: Forms Of Silk‐based Materialsmentioning

confidence: 99%

“…This combination of functional materials and spinning/processing technology will result in silk textiles that can satisfy the expanding demands. 72…”

Section: Textilesmentioning

confidence: 99%

Silk‐based conductive materials for smart biointerfaces

2023

Smart Medicine

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“…53 Ascribed to good flexibility, high water content and cross-linked network structures, hydrogels are expected to be connected with soft neural tissues, realizing soft interaction between human and electronic devices to overcome the mechanical mismatch problem of traditional electronic devices. 54,[64][65][66] More recently, Madden et al discussed the piezoelectric mechanism of piezoelectric F I G U R E 2 Multifunctional BT nanomaterials. (A) Fourier transform infrared spectra (i), transmission electron microscope image (ii), energy dispersive X-ray spectroscopy mapping results (iii, iv) of PMMA@BTNWs.…”

Section: Organic Piezoelectric Polymersmentioning

confidence: 99%

“…Ascribed to good flexibility, high water content and cross‐linked network structures, hydrogels are expected to be connected with soft neural tissues, realizing soft interaction between human and electronic devices to overcome the mechanical mismatch problem of traditional electronic devices 54,64–66 . More recently, Madden et al.…”

Section: Classification Of Piezoelectric Biomaterialsmentioning

confidence: 99%

Piezoelectric biomaterials for neural tissue engineering

Zhang

Wang

et al. 2023

Smart Medicine

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Nerve injury caused by trauma or iatrogenic trauma can lead to loss of sensory and motor function, resulting in paralysis of patients. Inspired by endogenous bioelectricity and extracellular matrix, various external physical and chemical stimuli have been introduced to treat nerve injury. Benefiting from the self‐power feature and great biocompatibility, piezoelectric biomaterials have attracted widespread attention in biomedical applications, especially in neural tissue engineering. Here, we provide an overview of the development of piezoelectric biomaterials for neural tissue engineering. First, several types of piezoelectric biomaterials are introduced, including inorganic piezoelectric nanomaterials, organic piezoelectric polymers, and their derivates. Then, we focus on the in vitro and in vivo external energy‐driven piezoelectric effects involving ultrasound, mechanical movement, and other external field‐driven piezoelectric effects. Neuroengineering applications of the piezoelectric biomaterials as in vivo grafts for the treatment of central nerve injury and peripheral nerve injury are also discussed and highlighted. Finally, the current challenges and future development of piezoelectric biomaterials for promoting nerve regeneration and treating neurological diseases are presented.

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“…[12][13][14][15][16] Based on the different sources of raw materials, hydrogels can be classified into natural polymer hydrogels (such as gelatin, sodium alginate, hyaluronic acid, silk fibroin, and chitosan) and synthetic polymer hydrogels (such as polyacrylic acid, polyvinyl alcohol, and polyacrylamide), and the appropriate hydrogel type can be selected according to specific application requirements. [17][18][19][20] Moreover, the chemical and biophysical properties of the obtained hydrogels can be efficiently modulated by changing the way and degree of crosslinking. [21][22][23][24] However, the isotropic nature of conventional hydrogels limits their potential to mimic the anisotropic features of different biological tissues in vivo.…”

Section: Introductionmentioning

confidence: 99%