Silk Fibroin Hydrogels Incorporated with the Antioxidant Extract of Stryphnodendron adstringens Bark

Abstract

Barbatimão (Stryphnodendron adstringens) is a Brazilian medicinal plant known for its pharmacological properties, including healing activity related to its phenolic composition, which is chiefly given by tannins. In order to preserve its stability and bioactivity, barbatimão extracts can be incorporated into (bio-)polymeric matrixes, of which silk fibroin stands out due to its versatility and tunable properties. This work aimed to obtain barbatimão bark extract rich in phenolic compounds and evaluate its incorporation in fibroin hydrogels. From the extraction process, it was observed that the PG (propylene glycol) extract presented a higher global yield (X0) and phenolic compounds (TPC) than the ET (ethanol) extract. Furthermore, the antioxidant activity (ORAC and FRAP) was similar between both extracts. Regarding the hydrogels, morphological, chemical, thermal, and mechanical characterizations were performed to understand the influence of the barbatimão extract and the solvent on the fibroin hydrogel properties. As a result, the hydrogels containing the barbatimão PG extract (BT/PG hydrogels) showed the better physical–chemical and structural performance. Therefore, these hydrogels should be further investigated regarding their potential in medical and pharmaceutical applications, especially in wound healing.

Release of delta-9-tetrahydrocannabinol from polyvinyl alcohol hydrogels and its safe interaction with human skin fibroblasts

“…Frontiers in Drug Delivery frontiersin.org form hydrogels for SEM observation. These results supported those reported previously, confirming the incapacity of PG, VG, and PG-VG to form manually manipulable hydrogels (de Brito et al, 2022).…”

Stryphnodendron adstringens have a modulatory effect on inflammatory cytokines markers of in vitro activated macrophages

“…Scientific reports corroborate the strong wound-healing activity of S. adstringens [7][8][9][10][11] and experimental findings suggest its therapeutic effect on some chronic inflammatory or infectious conditions [12][13][14][15][16][17][18]. These results suggested that S. adstringens had a relevant anti-inflammatory role, involving its ability to modulate bone marrow macrophage polarization showing a reduction in interleukin 6 (IL-6) cytokines.…”

Ocorrência de insetos em frutos de Stryphnodendron adstringens (Mart.) Coville (Fabales: Fabaceae) no bioma Cerrado, em Minas Gerais, Brasil

“…A espécie Stryphnodendron adstringens (Mart.) Coville (Fabales: Fabaceae), conhecida popularmente como barbatimão, devido a suas propriedades farmacológicas comprovadas cientificamente, é amplamente utilizada e estudada como planta medicinal em diversas regiões brasileiras (Freitas et al 2018;Ricardo et al 2018;Pereira Junior et al 2020;Brito et al 2022), especialmente em ensaios in vitro (Lima et al 2016;Baldivia et al 2018). A casca da árvore de S. adstringens é a principal parte utilizada para fins medicinais, seguida das folhas; o tronco é utilizado para fins madeireiros; a planta inteira tem valor ornamental; e aliado a isso, o barbatimão tem importância para indústria cosmética e na produção de corantes e de taninos (Lameira et al 2022).…”