2011
DOI: 10.1016/j.biomaterials.2010.12.041
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Silk fibroin in ocular tissue reconstruction

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Cited by 119 publications
(93 citation statements)
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“…A number of biomaterials have been assessed as scaffolds (Feng et al, 2014) for transfer of corneal epithelial stem cells and transient-amplifying cells to the ocular surface (Joe & Yeung, 2014), and silk fibroin shows promise for corneo-limbal reconstruction (Harkin et al, 2011;Bray et al, 2012). We aimed to engineer a biomaterial suitable for ocular surface repair.…”
Section: Introductionmentioning
confidence: 99%
“…A number of biomaterials have been assessed as scaffolds (Feng et al, 2014) for transfer of corneal epithelial stem cells and transient-amplifying cells to the ocular surface (Joe & Yeung, 2014), and silk fibroin shows promise for corneo-limbal reconstruction (Harkin et al, 2011;Bray et al, 2012). We aimed to engineer a biomaterial suitable for ocular surface repair.…”
Section: Introductionmentioning
confidence: 99%
“…While little of the native full-length protein remains following processing, the resulting peptide solutions can subsequently be used to generate a variety of stable and biocompatible materials including freestanding membranes, electro-spun fibers and porous sponges [24]. Of these three materials, the freestanding BMSF membranes have received most attention for potential use in corneal tissue reconstruction owing to their high degree of transparency and general handling properties [25][26][27][28].…”
Section: • Silk Fibroin Based Constructsmentioning
confidence: 99%
“…This leaves a fibrous material that can be dissolved and then processed into many forms including transparent films with mechanical properties and degradation behavior that can be tailored for the specific application. [34] Corneal epithelial cells have been shown to attach and grow on fibroin films in vitro but that the presence of serum is essential and for primary cells a feeder-cell layer may be required suggesting that specific cell adhesive molecules may be required to aid cell attachment to the surface. An alternative use of silk fibroin has been as a reinforcing element in collagen-based membranes.…”
Section: Other Natural Polymers: Silks and Keratinmentioning
confidence: 99%