Silk fibroin nanocomposites as tissue engineering scaffolds – A systematic review

Zuluaga-Vélez, Augusto; Quintero-Martínez, Adrián; Orozco, Lina M.; Sepúlveda-Arias, Juan Carlos

doi:10.1016/j.biopha.2021.111924

Cited by 41 publications

(29 citation statements)

References 129 publications

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“…Among plenty scaffolds, silk fibroin (SF) is a promising candidate with numerous researches (Wenhao et al, 2020;Shen et al, 2022). In the structure of SF, the light (L) chains, heavy (H) chains and the hydrophobically linked glycoprotein P25 are crosslinked to form an H-L complex with anti-parallel betasheets (β-sheets) (Figure 1) (Wongpinyochit et al, 2018;Zuluaga-Velez et al, 2021). SF scaffolds have many advantages, including excellent biocompatibility, satisfying mechanical property, controllable biodegradability and structural adjustability (Zhang et al, 2021;Zuluaga-Velez et al, 2021;Li and Sun, 2022).…”

Section: Introductionmentioning

confidence: 99%

Silk fibroin scaffolds: A promising candidate for bone regeneration

Lin²,

Zhao³

et al. 2022

Front. Bioeng. Biotechnol.

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It remains a big challenge in clinical practice to repair large-sized bone defects and many factors limit the application of autografts and allografts, The application of exogenous scaffolds is an alternate strategy for bone regeneration, among which the silk fibroin (SF) scaffold is a promising candidate. Due to the advantages of excellent biocompatibility, satisfying mechanical property, controllable biodegradability and structural adjustability, SF scaffolds exhibit great potential in bone regeneration with the help of well-designed structures, bioactive components and functional surface modification. This review will summarize the cell and tissue interaction with SF scaffolds, techniques to fabricate SF-based scaffolds and modifications of SF scaffolds to enhance osteogenesis, which will provide a deep and comprehensive insight into SF scaffolds and inspire the design and fabrication of novel SF scaffolds for superior osteogenic performance. However, there still needs more comprehensive efforts to promote better clinical translation of SF scaffolds, including more experiments in big animal models and clinical trials. Furthermore, deeper investigations are also in demand to reveal the degradation and clearing mechanisms of SF scaffolds and evaluate the influence of degradation products.

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Section: Introductionmentioning

confidence: 99%

Silk fibroin scaffolds: A promising candidate for bone regeneration

Lin²,

Zhao³

et al. 2022

Front. Bioeng. Biotechnol.

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“…Another protein that meets the demands for the synthesis of tissue engineering scaffolds is silk fibroin (SF) on the basis of its high environmental and mechanical stability, low immunogenicity, and increased biocompatibility [126]. The rich content of amino moieties of this protein provides countless possibilities to adjust the chemical configuration through functionalization with different compounds.…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Graphene Oxide–Protein-Based Scaffolds for Tissue Engineering: Recent Advances and Applications

et al. 2022

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The field of tissue engineering is constantly evolving as it aims to develop bioengineered and functional tissues and organs for repair or replacement. Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. This review critically focuses on opportunities to employ protein–graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. Herein, recent applications and the biological activity of nanocomposite bioconjugates are analyzed with respect to cell viability and proliferation, along with the ability of these constructs to sustain the formation of new and functional tissue. Novel strategies and approaches based on stem cell therapy, as well as the involvement of the extracellular matrix in the design of smart nanoplatforms, are discussed.

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“…When applied to cartilage TE, scaffolds with high mechanical strength, such as those constructed AF-related materials [83,231,[235][236][237], need to be considered. At the same time, it is necessary to enhance cell adhesion for proteins such as collagen [84,232,233,238] and gelatin [220].…”

Section: Cartilage Tissue Repairmentioning

confidence: 99%

Natural polymer‐based adhesive hydrogel for biomedical applications

Long

Xie

2022

Biosurface and Biotribology

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Hydrogel is a polymer network system that can form a hydrophilic three‐dimensional network structure through different cross‐linking methods. In recent years, hydrogels have received considerable attention due to their good biocompatibility and biodegradability by introducing different cross‐linking mechanisms and functional components. Compared with synthetic hydrogels, natural polymer‐based hydrogels have low biotoxicity, high cell affinity, and great potential for biomedical fields; however, their mechanical properties and tissue adhesion capabilities have been unable to meet clinical requirements. In recent years, many efforts have been made to solve these issues. In this review, the recent progress in the field of natural polymer‐based adhesive hydrogels is highlighted. The authors first introduce the general design principles for the natural polymer‐based adhesive hydrogels being used as excellent tissue adhesives and the challenges associated with their design. Next, their usages in biomedical applications are summarised, such as wound healing, haemostasis, nerve repair, bone tissue repair, cartilage tissue repair, electronic devices, and other tissue repairs. Finally, the potential challenges of natural polymer‐based adhesive hydrogels are presented.

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Silk fibroin nanocomposites as tissue engineering scaffolds – A systematic review

Cited by 41 publications

References 129 publications

Silk fibroin scaffolds: A promising candidate for bone regeneration

Silk fibroin scaffolds: A promising candidate for bone regeneration

Graphene Oxide–Protein-Based Scaffolds for Tissue Engineering: Recent Advances and Applications

Natural polymer‐based adhesive hydrogel for biomedical applications

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