Silk/polyols/GOD microneedle based electrochemical biosensor for continuous glucose monitoring

Zhao, Liang; Wen, Zhuangzhuang; Jiang, Fujian; Zheng, Zhaozhu; Lu, Shenzhou

doi:10.1039/c9ra10374k

Cited by 78 publications

(55 citation statements)

References 39 publications

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“…Microneedle-based electrodes have been demonstrated for minimally invasive detection of a variety of analytes, such as glucose, lactate, uric acid, etc. [104][105][106]. As shown in Figure 4D, an example of a second-generation-based biosensor was demonstrated in a microneedle platform for lactate detection [101].…”

Section: Developing Lactate Sensorsmentioning

confidence: 96%

Applying Nanomaterials to Modern Biomedical Electrochemical Detection of Metabolites, Electrolytes, and Pathogens

2020

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Personal biosensors and bioelectronics have been demonstrated for use in out-of-clinic biomedical devices. Such modern devices have the potential to transform traditional clinical analysis into a new approach, allowing patients or users to screen their own health or warning of diseases. Researchers aim to explore the opportunities of easy-to-wear and easy-to-carry sensors that would empower users to detect biomarkers, electrolytes, or pathogens at home in a rapid and easy way. This mobility would open the door for early diagnosis and personalized healthcare management to a wide audience. In this review, we focus on the recent progress made in modern electrochemical sensors, which holds promising potential to support point-of-care technologies. Key original research articles covered in this review are mainly experimental reports published from 2018 to 2020. Strategies for the detection of metabolites, ions, and viruses are updated in this article. The relevant challenges and opportunities of applying nanomaterials to support the fabrication of new electrochemical biosensors are also discussed. Finally, perspectives regarding potential benefits and current challenges of the technology are included. The growing area of personal biosensors is expected to push their application closer to a new phase of biomedical advancement.

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Section: Developing Lactate Sensorsmentioning

confidence: 96%

Applying Nanomaterials to Modern Biomedical Electrochemical Detection of Metabolites, Electrolytes, and Pathogens

2020

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“…Hollow MNs were used to extract and collect ISF out of body or their lumen, functionalised to act as the biosensor, or their hollow is filled with metal and metal-based material to act as bio-electrodes. The reported fabrication technique for hollow MNs involves combined methods, including standard photolithography and etching [119][120][121][122][123], DRIE and plasma etching [92,118,[124][125][126][127], and casting and plasma etching [121,128,129]. They are also fabricated using photolithographic masks with an array of transparent rings [130], CO 2 laser machining [131], injection moulding [132], 3D printing [133], and using the CNC-micromachining technique [134].…”

Section: Hollow Mnsmentioning

confidence: 99%

Microneedle Arrays for Sampling and Sensing Skin Interstitial Fluid

et al. 2021

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Dermal interstitial fluid (ISF) is a novel source of biomarkers that can be considered as an alternative to blood sampling for disease diagnosis and treatment. Nevertheless, in vivo extraction and analysis of ISF are challenging. On the other hand, microneedle (MN) technology can address most of the challenges associated with dermal ISF extraction and is well suited for long-term, continuous ISF monitoring as well as in situ detection. In this review, we first briefly summarise the different dermal ISF collection methods and compare them with MN methods. Next, we elaborate on the design considerations and biocompatibility of MNs. Subsequently, the fabrication technologies of various MNs used for dermal ISF extraction, including solid MNs, hollow MNs, porous MNs, and hydrogel MNs, are thoroughly explained. In addition, different sensing mechanisms of ISF detection are discussed in detail. Subsequently, we identify the challenges and propose the possible solutions associated with ISF extraction. A detailed investigation is provided for the transport and sampling mechanism of ISF in vivo. Also, the current in vitro skin model integrated with the MN arrays is discussed. Finally, future directions to develop a point-of-care (POC) device to sample ISF are proposed.

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“…Hollow MNs were used to extract and collect ISF out of body or their lumen functionalised to act as the biosensor or their hollow is filled with metal and metal-based material to act as bio-electrodes. The reported fabrication technique for hollow MNs are combined methods, including standard photolithography and etching [86,88,[115][116][117], DRIE and plasma etching [87,114,[118][119][120][121], and casting and plasma etching [88,122,123]. They were also fabricated using CO2 laser machining [124], injection moulding [125], 3D printing [126], CNC-micromachining technique [127].…”

Section: Hollow Mnsmentioning

confidence: 99%

“…In the other work, a mixture of silk with D-sorbitol and glucose oxidase was cast into the PDMS mould. Then, enzyme coated metal wires were inserted into the mould and allowed to dry to produce electrochemical transducers for monitoring glucose continuously [123]. In contrast to the solid MNs, only a few articles reported the casting method for the hollow MNs fabrication.…”

Section: Casting and Plasma Etchingmentioning

confidence: 99%

“…For example, hydrogel MNs were prepared from an aqueous mixture of hydrolysed poly (methyl-vinylether-co-maleic anhydride) and poly(ethyleneglycol) which was crosslinked by heating [135][136][137][138] and applied for lithium detection [138]. The other hydrogel MNs made of methacrylated hyaluronic acid [66,90], polyacrylamide [139], polyvinyl alcohol and chitosan [65], and gelatin methacryloyl [123,140] were reported for optical fluorescence sensing [139], cell-free DNA monitoring [141], glucose measurement [65] and urea sensing [140]. With respect to hydrogel properties, the casing method is the most appropriate fabrication method for hydrogel MNs.…”

Section: Hydrogel Mnsmentioning

confidence: 99%

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Microneedle Arrays for Sampling and Sensing Dermal Interstitial Fluid

Kashaninejad¹,

Munaz²,

Moghadas³

et al. 2021

Preprint

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Dermal interstitial fluid (ISF) is a novel source of biomarkers that can be considered as an alternative to blood sampling for disease diagnosis and treatment. Nevertheless, in vivo extraction and analysis of ISF are challenging. On the other hand, microneedle (MN) technology can address most of the challenges associated with dermal ISF extraction and is well-suited for long-term, continuous ISF monitoring as well as in situ detection. In this review, we first briefly summarise the different dermal ISF collection methods and compare them with MN methods. Next, we elaborate on the design considerations and biocompatibility of MNs. Subsequently, the fabrication technologies of various MNs used for dermal ISF extraction, including solid MNs, hollow MNs, porous MNs and hydrogel MNs, are thoroughly explained. In addition, different sensing mechanisms of ISF detection will be discussed in detail. Subsequently, we identify the challenges and propose the possible solutions associated with ISF extraction. A detailed investigation is provided for the transport and sampling mechanism of ISF in vivo. Also, the current in vitro skin model integrated with the MN arrays will be discussed. Finally, future directions to develop a point-of-care (POC) device to sample ISF are proposed.

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Silk/polyols/GOD microneedle based electrochemical biosensor for continuous glucose monitoring

Abstract: This work illustrates the feasibility of a microneedle based electrochemical biosensor for continuous glucose monitoring.

Cited by 78 publications

References 39 publications

Applying Nanomaterials to Modern Biomedical Electrochemical Detection of Metabolites, Electrolytes, and Pathogens

Applying Nanomaterials to Modern Biomedical Electrochemical Detection of Metabolites, Electrolytes, and Pathogens

Microneedle Arrays for Sampling and Sensing Skin Interstitial Fluid

Microneedle Arrays for Sampling and Sensing Dermal Interstitial Fluid

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