Silk's cancer applications as a biodegradable material

Blake, Sara; Kim, Na Yoon; Kong, Na; Ouyang, Jun; Tao, Wei

doi:10.1016/j.mtsust.2021.100069

Cited by 14 publications

(8 citation statements)

References 87 publications

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“…Fibroin is responsible for silk’s superior properties; in opposition, in most cases, sericin is removed by certain thermos–chemical treatments [ 68 ]. At this time, fibroin is being explored by a wide range of researchers that develop various SF-based biomaterials, such as hydrogels, nanoparticles, scaffolds, microtubes, biofilms, and sponges ( Figure 2 ), which exhibit great importance for the life science fields [ 69 , 70 ].…”

Section: Sericultural By-productsmentioning

confidence: 99%

Sericultural By-Products: The Potential for Alternative Therapy in Cancer Drug Design

et al. 2023

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Major progress has been made in cancer research; however, cancer remains one of the most important health-related burdens. Sericulture importance is no longer limited to the textile industry, but its by-products, such as silk fibroin or mulberry, exhibit great impact in the cancer research area. Fibroin, the pivotal compound that is found in silk, owns superior biocompatibility and biodegradability, representing one of the most important biomaterials. Numerous studies have reported its successful use as a drug delivery system, and it is currently used to develop three-dimensional tumor models that lead to a better understanding of cancer biology and play a great role in the development of novel antitumoral strategies. Moreover, sericin’s cytotoxic effect on various tumoral cell lines has been reported, but also, it has been used as a nanocarrier for target therapeutic agents. On the other hand, mulberry compounds include various bioactive elements that are well known for their antitumoral activities, such as polyphenols or anthocyanins. In this review, the latest progress of using sericultural by-products in cancer therapy is discussed by highlighting their notable impact in developing novel effective drug strategies.

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Section: Sericultural By-productsmentioning

confidence: 99%

Sericultural By-Products: The Potential for Alternative Therapy in Cancer Drug Design

et al. 2023

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“…In addition, SF and its composites can also be applied in biomedical applications due to other unique properties including good biocompatibility, good oxygen and water vapor permeability, low inflammatory response and biodegradability 33–35 . It is worth noting that the biodegradability of silk is quite friendly to the environment as it can help alleviate the white pollution problem 36 . Also, some work has been conducted to demonstrate the excellent biodegradability of SF 37–39 .…”

Section: Introductionmentioning

confidence: 99%

“…[33][34][35] It is worth noting that the biodegradability of silk is quite friendly to the environment as it can help alleviate the white pollution problem. 36 Also, some work has been conducted to demonstrate the excellent biodegradability of SF. [37][38][39] For example, Catto et al conducted the enzymatic degradation test of electrospun SF and found that the electrospun SF can be degraded by 35% in 24 days.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable radiative cooling membrane based on electrospun silk fibroin fiber

Xiang

Chang

et al. 2023

Polymers for Advanced Techs

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Biodegradable radiative cooling materials can achieve both zero‐energy cooling and environmental friendliness. Natural silk cocoon exhibits both high solar reflectivity and mid‐infrared emissivity owing to its unique structure and composition, while it possesses excellent biodegradability. Herein, we restructure the natural silk by electrospinning to obtain scalable and biodegradable silk fibroin (SF) fiber membranes with enhanced optical properties. Specially, nano‐sized fibers exhibit better optical properties than micrometer‐sized ones. The fabricated SF nanofiber membrane can achieve ultra‐high average solar reflectance and infrared emittance of 96% and ~97%, respectively. Such outstanding optical properties enables the fiber membrane to yield an average sub‐ambient cooling temperature of ~6°C in the outdoor environment even under a peak solar intensity of ~800 W m−2. Overall, the resulted SF fiber membranes promise a wide range of applications such as building energy efficiency, cold‐chain transportation, in‐vehicle temperature control, outdoor precision instrument protection and outdoor personal thermal management.

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“…6 Based on the excellent mechanical properties, high moisture absorption, soft hand feel and good biocompatibility, silk fabrics have been broadly used in the fields of textiles, 7,8 sensors, 9,10 energy harvesters, 11 and biomedical materials. 12,13 Although silk fabrics possess the above-described advantages, they are easy to be stained during daily wear, for example, by grease from the human body as well as by food and drinks. Moreover, due to the good hydrophilicity of silk fabrics, they can absorb and maintain a large amount of sweat during outdoor activities, which induces a significant reduction of the comfort for the human body.…”

Section: Introductionmentioning

confidence: 99%

“…As a fiber from the silkworm, silk is mainly composed of the silk fibroin, sericin, and some impurities 6 . Based on the excellent mechanical properties, high moisture absorption, soft hand feel and good biocompatibility, silk fabrics have been broadly used in the fields of textiles, 7,8 sensors, 9,10 energy harvesters, 11 and biomedical materials 12,13 . Although silk fabrics possess the above‐described advantages, they are easy to be stained during daily wear, for example, by grease from the human body as well as by food and drinks.…”

Section: Introductionmentioning

confidence: 99%

Easy care of silk fabrics realized by crosslinking thermo‐responsive copolymer film on its surface

Zhu

et al. 2022

Journal of Polymer Science

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An easy care of silk fabrics is realized by crosslinking a thermo‐responsive copolymer film onto its surface. The thermo‐responsive copolymer poly(N‐isopropylacrylamide‐co‐oligo[ethylene glycol] methyl ether methacrylate‐co‐ethylene glycol methacrylate), abbreviated as P(NM‐co‐OA300‐co‐EA360), is synthesized by sequential atom transfer radical polymerization. By applying 1,2,3,4‐butanetetracarboxylic acid as crosslinker, the thermo‐responsive P(NM‐co‐OA300‐co‐EA360) film can be immobilized onto the silk fabrics. The transition temperature (TT) of the P(NM‐co‐OA300‐co‐EA360) film crosslinked on silk fabrics is around 46 °C. The reversible transition behavior can effectively reduce the attachment between lipophilic stains and P(NM‐co‐OA300‐co‐EA360) film, inducing a high efficiency of stain removal. Simply rinsing with deionized water at 25 °C (below its TT) for 30 s, 60% of stains can be removed. Moreover, the crosslinked P(NM‐co‐OA300‐co‐EA360) film turns hydrophobic during outdoor activities or drying. Thus, the repelled water molecules can be easily evaporated from the silk fabrics and the drying process is 25% faster than that without crosslinked P(NM‐co‐OA300‐co‐EA360) film. Based on the excellent performance of stain removal and quick drying, the silk fabrics crosslinked with thermo‐responsive copolymer film can be broadly used to design silk‐based costumes for daily use.

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Silk's cancer applications as a biodegradable material

Cited by 14 publications

References 87 publications

Sericultural By-Products: The Potential for Alternative Therapy in Cancer Drug Design

Sericultural By-Products: The Potential for Alternative Therapy in Cancer Drug Design

Biodegradable radiative cooling membrane based on electrospun silk fibroin fiber

Easy care of silk fabrics realized by crosslinking thermo‐responsive copolymer film on its surface

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