Silodosin vs tamsulosin in the management of distal ureteric stones: A prospective randomised study

Elgalaly, Hazem; Sakr, Ahmed; Fawzi, A.M.; Salem, Emad A.; Desoky, Esam; Shahin, Ashraf; Kamel, Mostafa

doi:10.1016/j.aju.2015.11.004

Cited by 27 publications

(46 citation statements)

References 24 publications

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“…This may be explained by the selective alpha 1A adrenoceptive antagonistic action of silodosin when compared to alpha 1A antagonistic action of tamsulosin suggesting better clinical usefulness of silodosin. These results of the present study were comparable with studies done by Elgalaly et al [23], Gupta et al [19], and Kumar et al [20] regarding the shorter stone expulsion time of silodosin over tamsulosin; however, the stone expulsion time in this study is shorter than these studies, and this may be attributed to the difference in patients and stone characteristics.…”

Section: Discussionsupporting

confidence: 37%

“…The increase in the intra ureteral pressure that occurs above the site of ureteral obstruction by the stone is the main etiology of ureteral colicky pain [20]. The alpha adreno- ceptor blockers may alleviate the ureteric colic by blocking C fibers that mediates pain and decreases the analgesic requirements by decreasing the stone expulsion time [23]. In this study, the analgesic requirements are comparable in both silodosin and tamsulosin groups, as it was 193 ± 83.3 and 204.2 ± 95.1 mg respectively (p = 0.58) with no significant difference.…”

Section: Discussionmentioning

confidence: 99%

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Comparative Study between Silodosin and Tamsulosin in Expectant Therapy of Distal Ureteral Stones

et al. 2018

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Objective: To compare the efficacy and safety of silodosin against tamsulosin as medical expulsion therapeutic agent in stone lower 1/3rd ureter. Patients and Methods: One hundred fifty patients divided equally into 2 groups I and II received silodosin 8 mg and tamsulosin 0.4 mg respectively. Patients aged 18 years or older having single unilateral stone 10 mm or less were included in the study. Patients with bilateral or multiple stones, marked hydronephrosis, previous open or endoscopic surgery and having urinary infection were excluded. Patients were followed weekly for 4 weeks by ultrasonography, plain radiography of the urinary tract and CT of the urinary tract when indicated. Results: Silodosin showed better results against tamsulosin as stone expulsion rate in silodosin and tamsulosin groups was 82.4 and 61.5% respectively with significant difference (p = 0.007). Also, the stone expulsion time was significantly lower in silodosin against tamsulosin groups as it was 9.4 ± 3.8 vs. 12.7 ± 5.1 days in group I and II respectively (p = 0.001). The adverse effects were comparable with non-significant more retrograde ejaculation in the silodosin group. Conclusion: Silodosin showed better efficacy in the stone expulsion rate and time with comparable safety of both drugs, with nonsignificant more retrograde ejaculation in silodosin.

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Section: Discussionsupporting

confidence: 37%

Section: Discussionmentioning

confidence: 99%

Comparative Study between Silodosin and Tamsulosin in Expectant Therapy of Distal Ureteral Stones

et al. 2018

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“…In October 2008, silodosin was approved by the the US Food and Drug Administration (FDA) for lower urinary tract symptoms and benign prostatic hyperplasia . Elgalaly et al also reported that silodosin had higher stone expulsion rate and lass stone expulsion time compared to tamsulosin in present study . In 2017, Rahman et al analyzed 120 patients study.…”

Section: Discussionmentioning

confidence: 53%

“…27 Elgalaly et al also reported that silodosin had higher stone expulsion rate and lass stone expulsion time compared to tamsulosin in present study. 28 In 2017, Rahman et al analyzed 120 patients study.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of phosphodiesterase type 5 inhibitors for the treatment of distal ureteral calculi of 5 to 10 mm in size: A systematic review and network meta‐analysis

Qiu

Jin

et al. 2019

The Kaohsiung J of Med Scie

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To evaluate the Efficacy and safety of phosphodiesterase type 5 inhibitors as a medical therapy for distal ureteral calculi by means of a systematic review and network meta‐analysis (NMA). We searched the Embase, Medline, and the Cochrane Central Register of Controlled Trials for randomised controlled trials (RCTs) published before May, 2017. Stone passage rate as the primary outcome. We used random effects model for pairwise meta‐analyses and Bayesian random effects model for NMA. We evaluated the quality of evidence by the GRADE framework for each network estimate. Five RCTs (861 patients) comparing four different interventions. The results of NMA showed that compared with tamsulosin alone, tamsulosin combined with tadalafil group was associated with significantly higher stone passage rate (odds radio [OR] 2.55, 95% credible intervals [Crl] 1.11 to 5.89). When considering stone expulsion rate, compared with tamsulosin, silodosin was ranked best (OR 3.58, 95% Crl 1.13 to 11.91), followed by tamsulosin combined with tadalafil (OR 2.55, 95% Crl 1.11 to 5.89) and tadalafil alone (OR 1.86, 95% Crl 0.95 to 4.25). No significant difference was found considering safety profiles between any interventions. This meta‐analysis indicates that tamsulosin combined with tadalafil is an effective treatment option for ureteral stones with a low occurrence of side effects. Clinicians should take all known safety and compliance of patients into account when choosing an optimal strategy. Since sample size of included studies, further RCTs are strongly encouraged to address the clinical question.

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“…Their efficacy was comparable in the majority of studies comparing these agents, and their superiority to each other was assessed according to their side effect profile. [12,13] Significant side effects, such as hypotension and retrograde ejaculation with alpha-blockers, and visual and cardiac disorders with the use of PDE5Is may occur. [14,15] Viburnum opulus L. is a plant extract promising to protect patients from these side effects and to provide an alternative effective treatment method for distal ureteral stones <10 mm.…”

Section: Introductionmentioning

confidence: 99%

The evaluation of the effectiveness of Gilaburu (Viburnum opulus L.) extract in the medical expulsive treatment of distal ureteral stones

Kızılay

Ülker²,

Çelik³

et al. 2019

Turkish Journal of Urology

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Objective: Medical expulsive therapy is an important non-invasive treatment modality that facilitates the passage of ureteral stones. The aim of the present study was to evaluate the efficacy of Gilaburu (Viburnum opulus) extract in the treatment of distal ureteral stones <10 mm. Material and methods: Data of 103 patients were retrospectively analyzed. Patients were divided into two groups: those given V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand (n=53) and those given only diclofenac sodium 50 mg peroral on-demand (n=50). Comparisons of stone expulsion rates and the elapsed time until the expulsion between the groups were determined as primary outcome measures. The comparison of the need for additional treatment [ureteroscopy (URS) or extracorporeal shock wave lithotripsy (ESWL)], the need for emergency admission, analgesic requirement, and the complication rates in additional treatment were determined as secondary outcome measures. Results: The mean age of the patients was 45.8±14.5 years. The rate of stone expulsion was significantly higher (82% vs. 66%, p= 0.026), and elapsed time to stone expulsion was significantly shorter (9±1.8 vs. 14±2.3 day, p= 0.018) in the V. opulus group. The need for additional treatment (URS and ESWL) and analgesic requirement was less in the V. opulus group (9.4% vs. 20%, p= 0.038 and 24.5% vs. 44%, p= 0.042, respectively). Conclusion: V. opulus is an herbal treatment alternative that facilitates the passage of ureteral stones <10 mm. Prospective, randomized studies are needed to support these results.

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Silodosin vs tamsulosin in the management of distal ureteric stones: A prospective randomised study

Cited by 27 publications

References 24 publications

Comparative Study between Silodosin and Tamsulosin in Expectant Therapy of Distal Ureteral Stones

Comparative Study between Silodosin and Tamsulosin in Expectant Therapy of Distal Ureteral Stones

Efficacy and safety of phosphodiesterase type 5 inhibitors for the treatment of distal ureteral calculi of 5 to 10 mm in size: A systematic review and network meta‐analysis

The evaluation of the effectiveness of Gilaburu (Viburnum opulus L.) extract in the medical expulsive treatment of distal ureteral stones

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