Silsesquioxane polymer as a potential scaffold for laryngeal reconstruction

Mehrban, Nazia; Bowen, James; Tait, Angela; Darbyshire, Arnold; Virasami, Alex; Lowdell, Mark W.; Birchall, Martin A.

doi:10.1016/j.msec.2018.07.003

Cited by 12 publications

(10 citation statements)

References 82 publications

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“…Heatmap representing the proportion of publications by year that utilized specific translational research methodologies from construct characterization to human trial to investigate laryngeal tissue engineering 85‐87,91,92,94,96,97,198‐306 …”

Section: Discussionmentioning

confidence: 99%

Tissue engineering applications in otolaryngology—The state of translation

Niermeyer

Rodman

et al. 2020

Laryngoscope Investig Oto

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While tissue engineering holds significant potential to address current limitations in reconstructive surgery of the head and neck, few constructs have made their way into routine clinical use. In this review, we aim to appraise the state of head and neck tissue engineering over the past five years, with a specific focus on otologic, nasal, craniofacial bone, and laryngotracheal applications. A comprehensive scoping search of the PubMed database was performed and over 2000 article hits were returned with 290 articles included in the final review. These publications have addressed the hallmark characteristics of tissue engineering (cellular source, scaffold, and growth signaling) for head and neck anatomical sites. While there have been promising reports of effective tissue engineered interventions in small groups of human patients, the majority of research remains constrained to in vitro and in vivo studies aimed at furthering the understanding of the biological processes involved in tissue engineering. Further, differences in functional and cosmetic properties of the ear, nose, airway, and craniofacial bone affect the emphasis of investigation at each site. While otolaryngologists currently play a role in tissue engineering translational research, continued multidisciplinary efforts will likely be required to push the state of translation towards tissue‐engineered constructs available for routine clinical use. Level of Evidence NA.

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Section: Discussionmentioning

confidence: 99%

Tissue engineering applications in otolaryngology—The state of translation

Niermeyer

Rodman

et al. 2020

Laryngoscope Investig Oto

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“…It has been recently shown that these materials may be further modified to include a foamlike internal structure which could have implications towards long-term integration and reduced inflammation in vivo 22 .…”

Section: Discussionmentioning

confidence: 99%

In vivo feasibility study of the use of porous polyhedral oligomeric silsesquioxane implants in partial laryngeal reconstruction

Birchall

Herrmann

Sibbons

2019

Preprint

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Background: Loss of substantial volumes of laryngeal tissue after trauma or cancer significantly impairs quality of life. We hypothesised that repair of laryngeal defects with a candidate biomaterial, seeded with mesenchymal stem cells (MSC) and epithelial cells, may offer a therapeutic approach to this unmet need. Method:Moulded porous polyhedral oligomeric silsesquioxane polycarbonate-urea (POSS-PCU) scaffolds were seeded with human-derived MSC and epithelial cells, were implanted orthotopically into a defect created in the thyroid cartilage in eight pigs and monitored in vivo for 2 months. In vivo assessments were performed at 1, 2, 4 and 8 weeks post implantation.Histology was performed following termination.Results: Implant operations were uncomplicated. One pig was terminated early (2 weeks post-implantation) following expectoration of its implant. No other mortality or morbidity was observed. Endoscopy showed partial extrusion of implants at two weeks and complete extrusion of all implants by termination.Conclusions: POSS-PCU moulded laryngeal implants, in the present formulation, are extruded from the site of implantation between two-and eight-weeks post-surgery in pigs. In its present formulation and with the present, one-stage, protocol, this material does not appear to provide a suitable scaffold and vehicle for cells intended for partial laryngeal replacement in pigs.

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“…Although natural biomaterials such as decellularized lung ECM have the benefit of containing organ-specific signaling molecules and can provide architecture that closely mimics the native structure, synthetic materials that can be more readily controlled and manufactured on demand are emerging as a potential alternative. New advanced methods for creating tissue-specific materials for use in airway regeneration studies are emerging that can be used with novel biomaterials which can be further biochemically and biomechanically modified to direct cell behavior ( 32 ). This will be an important area of future investigation.…”

Section: Methodsmentioning

confidence: 99%

Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases 2017. An Official American Thoracic Society Workshop Report

Ryan¹,

Ikonomou²,

Atarod³

et al. 2019

Am J Respir Cell Mol Biol

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The University of Vermont Larner College of Medicine, in collaboration with the National Heart, Lung, and Blood Institute (NHLBI), the Alpha-1 Foundation, the American Thoracic Society, the Cystic Fibrosis Foundation, the European Respiratory Society, the International Society for Cell & Gene Therapy, and the Pulmonary Fibrosis Foundation, convened a workshop titled “Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases” from July 24 through 27, 2017, at the University of Vermont, Burlington, Vermont. The conference objectives were to review and discuss current understanding of the following topics: 1 ) stem and progenitor cell biology and the role that they play in endogenous repair or as cell therapies after lung injury, 2 ) the emerging role of extracellular vesicles as potential therapies, 3 ) ex vivo bioengineering of lung and airway tissue, and 4 ) progress in induced pluripotent stem cell protocols for deriving lung cell types and applications in disease modeling. All of these topics are research areas in which significant and exciting progress has been made over the past few years. In addition, issues surrounding the ethics and regulation of cell therapies worldwide were discussed, with a special emphasis on combating the growing problem of unproven cell interventions being administered to patients with lung diseases. Finally, future research directions were discussed, and opportunities for both basic and translational research were identified.

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Silsesquioxane polymer as a potential scaffold for laryngeal reconstruction

Cited by 12 publications

References 82 publications

Tissue engineering applications in otolaryngology—The state of translation

Tissue engineering applications in otolaryngology—The state of translation

In vivo feasibility study of the use of porous polyhedral oligomeric silsesquioxane implants in partial laryngeal reconstruction

Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases 2017. An Official American Thoracic Society Workshop Report

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