Silver Acetate Gum as a Deterrent to Smoking

Malcolm, Robert; Currey, Hal S.; Mitchell, Mary Ann; Keil, Julian

doi:10.1378/chest.90.1.107

Cited by 30 publications

(10 citation statements)

References 5 publications

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“…NRT attenuates the tobacco withdrawal symptoms and approximately doubles the success rate of quitting smoking relative to smoking. [46]…”

Section: Pharmacological Approchesmentioning

confidence: 99%

Pharmacotherapy of smoking cessation

Jiloha¹

2014

Indian J Psychiatry

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Nicotine in tobacco smoke causes not only pathophysiological changes in the smoker's body, but also develops tolerance to its own action with repeated use. Repeated exposure to nicotine develops neuroadaptation of the receptors, resulting in tolerance to many of the effects of nicotine. Pharmacotherapies for smoking cessation should reduce withdrawal symptoms and block the reinforcing effects of nicotine without causing excessive adverse effects. All forms of nicotine replacement therapy (NRT) – gum, patches and inhaler – and bupropion are safe and effective for increasing smoking cessation rates in the short and long-term use. Combination NRT (more than one therapy) may be indicated in patients who have failed monotherapy.

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“…NRT attenuates the tobacco withdrawal symptoms and approximately doubles the success rate of quitting smoking relative to smoking. [46]…”

Section: Pharmacological Approchesmentioning

confidence: 99%

Pharmacotherapy of smoking cessation

Jiloha¹

2014

Indian J Psychiatry

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Section: Populations With Potentially High Exposuresmentioning

confidence: 99%

“…Silver acetate in chewing gum has been classified as an over-the-counter smoking deterrent by the Food and Drug Administration (Malcolm et al 1986). Several cases of high body levels of silver have been reported (Malcolm et al 1986). A skin silver concentration thousands of times higher than would be expected as a normal value was found in a patient after an estimated 6 month exposure to silver acetate lozenges (East et al 1980;MacIntyre et al 1978).…”

Section: Populations With Potentially High Exposuresmentioning

confidence: 99%

A randomized controlled evaluation of absorption of silver with the use of silver alginate (Algidex) patches in very low birth weight (VLBW) infants with central lines

et al. 2009

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“…Zusammengefasst lassen diese Studien keine verbindliche Aussage zum Stellenwert dieser Verfahren zu. Silberazetat, in Verwendung als Lutschpastille oder Kau-gummi, zeigte in großen Studien keine oder nur bescheidene Wirkung (24,25). Das Inhalieren von Pfefferöldämpfen mildert das akute Craving (31).…”

Section: Sensorische Stimulanzienunclassified

Pharmakologische Möglichkeiten der Rückfallprophylaxe bei Nikotinabhängigkeit

Nowak¹,

Bäuerle²

2004

Nervenheilkunde

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ZusammenfassungDie Nikotinersatztherapie (Pflaster, Kaugummi oder Spray) hat einen wichtigen Stellenwert in der Behandlung der Nikotinsucht. Die damit erzielten Abstinenzquoten nach sechs bis zwölf Monaten schwanken je nach Darreichungsform zwischen 5 und 25%. Die Wirksamkeit dieser Verfahren beruht auf einer Reduktion von Entzugserscheinungen durch Stimulation der nikotinischen ACh-Rezeptoren. Als erste nicht-nikotinhaltige Substanz erhielt Bupropion SR (»slow release«) die Zulassung zur Raucherentwöhnung. In einer kontrollierten Studie waren ein Jahr nach Therapieende mit diesem selektiven Dopamin- und Noradrenalin-Wiederaufnahmehemmer noch 30% der Patienten abstinent. Somit stehen nun mehrere viel versprechende Ansätze zur Rückfallprophylaxe bei Nikotinabhängigkeit zur Verfügung.

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Silver Acetate Gum as a Deterrent to Smoking

Cited by 30 publications

References 5 publications

Pharmacotherapy of smoking cessation

Pharmacotherapy of smoking cessation

A randomized controlled evaluation of absorption of silver with the use of silver alginate (Algidex) patches in very low birth weight (VLBW) infants with central lines

Pharmakologische Möglichkeiten der Rückfallprophylaxe bei Nikotinabhängigkeit

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