Silver- and sulfadiazine-loaded nanostructured silica materials as potential replacement of silver sulfadiazine

Szegedi, Ágnes; Popova, Margarita; Yoncheva, Krassimira; Makk, Judit; Mihály, Judith; Shestakova, Pavletta

doi:10.1039/c4tb00619d

Cited by 41 publications

(17 citation statements)

References 37 publications

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“…Drug occlusion into the pores of the support and stronger drug-framework silver ions interaction could be the reason for its extended release. This prolonged release of SD is similar to that of found on silver containing nanoporous silica materials [29], but much faster than on polymer based systems loaded with AgSD [39].…”

Section: Fig 1 Sem Images Of the Parent Hy (A) And Sd/hy(ss) (B) Sasupporting

confidence: 80%

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Solid-state encapsulation of Ag and sulfadiazine on zeolite Y carrier

Mavrodinova

Popova

Yoncheva

et al. 2015

Journal of Colloid and Interface Science

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by Solid-state Ion Exchange (SSIE) procedure over zeolite Y, followed by deposition of sulfadiazine (SD) by dry mixing was examined for the preparation of topical antibacterial formulations. The ion-exchange and adsorptive properties of the zeolite matrix were utilized for the bactericidal Ag deposition and loading of antibiotic sulfadiazine.Experiments: Assessment of the encapsulation efficiency of both active components loaded by solid and liquid deposition methods was made by X-ray diffraction, TEM, FT-IR spectroscopy and thermogravimetric analysis (TGA). SD release kinetics was also determined.Findings: Sustained delivery of sulfadiazine has been observed from the Ag-modified zeolites compared to the parent HY material. It was found that if SD was loaded in solution, part of the zeolite silver ions was released and interacted with SD, forming AgSD. By solid-state SD deposition, the reaction between the drug and the silver was restricted within the limits of inter-atomic interaction, and total but prolonged drug release occurred.

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Section: Fig 1 Sem Images Of the Parent Hy (A) And Sd/hy(ss) (B) Sasupporting

confidence: 80%

“…The same phenomenon was experienced also in the case of SD loaded AgMCM-41 samples [29]. The band at 1552 cm -1 is present in the spectra of silver sulfadiazine (AgSD) compound and is assigned to the shifted ring vibrations of pyrimidine by the presence of Ag + .…”

Section: Fig 1 Sem Images Of the Parent Hy (A) And Sd/hy(ss) (B) Sasupporting

confidence: 66%

Solid-state encapsulation of Ag and sulfadiazine on zeolite Y carrier

Mavrodinova

Popova

Yoncheva

et al. 2015

Journal of Colloid and Interface Science

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“…Then the powdered products were washed 3 times with 5 ml water, and dried at 40°C Nitrogen physisorption measurements were carried out at -196°C using Thermo Scientific Surfer automatic volumetric adsorption analyzer. Before the analysis, silica samples were outgassed under high vacuum for 2 h at 250°C, whereas drug loaded samples were pretreated at 80°C for 3 h [28,29]. The pore-size distributions were calculated from the desorption isotherms by the BJH method.…”

Section: Quercetin Loadingmentioning

confidence: 99%

Preparation of efficient quercetin delivery system on Zn-modified mesoporous SBA-15 silica carrier

Trendafilova

Szegedi

Mihály

et al. 2017

Materials Science and Engineering: C

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Mesoporous silica material type SBA-15 was modified with different amounts of Zn (2 and 4 wt. %) by incipient wetness impregnation method in ethanol. The parent, Zn-modified and quercetin loaded samples, were characterized by XRD, N2 physisorption, TEM, thermal gravimetric analysis, UV-Vis and FT-IR spectroscopies and in vitro release of quercetin at pH 5.5 which is typical of dermal formulations. By this loading method anhydrous quercetin was formed on the silica carrier. It was found that the different hydrate forms of quercetin (dihydrate, monohydrate, anhydrite) significantly influence the physico-chemical properties of the delivery system. It was found that hydrate forms of quercetin can be differentiated by XRD and by FT-IR spectroscopic methods. Thus, by evaluating the interaction of the drug with the silica carrier the changes due to its hydration state always have to be taken into account. Formation of Zn-quercetin complex was evidenced on zinc modified SBA-15 silica by FT-IR spectroscopy. High quercetin loading capacity (over 40 wt. %) could be achieved on the parent and Zn-containing SBA-15 samples. The in-vitro release process at pH=5.5 showed slower quercetin release from Zn-modified SBA-15 samples compared to the parent one.Additionally, the comparative cytotoxic experiments evidenced that quercetin encapsulated in Zn-modified silica carriers has superior antineoplastic potential against HUT-29 cells compared to free drug. Zn-modified SBA-15 silica particles could be promising carriers for dermal delivery of quercetin.

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“…Before the adsorption analysis, the silica sample was outgassed under vacuum for 2 h at 200 °C, whereas modified and drug loaded samples were pretreated at 80 °C for 5 h [37,38].…”

Section: Characterizationmentioning

confidence: 99%

Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

Popova

Trendafilova

Szegedi

et al. 2016

Microporous and Mesoporous Materials

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SBA-16 and MCM-41 silica materials were synthesized and modified by post-synthesis method with different amounts of Zn (2 and 4 wt.%). Quercetin, a flavonol compound, was loaded by incipient wetness impregnation method on the pure silica and Zn-modified mesoporous MCM-41 and SBA-16 supports. The parent and drug loaded formulations were characterized by powder XRD, N 2 physisorption, thermal analysis, TEM, UV Vis and FT-IR spectroscopies. The formation of Zn:quercetin complex was studied by FT-IR spectroscopy and quantum-chemical calculations. Loading of quercetin on mesoporous carriers made the sustained delivery of the bioactive compound possible in a buffer with pH = 5.5, typical of dermal formulations. The results from the release experiments are in good accordance with the inter-action energy between the bioactive molecule and non-modified and Zn-modified mesoporous materials, predicted by the quantum-chemical calculations. For the first time the formation of the most stable Zn quercetin complexes loaded on the mesoporous silica materials were determined. The obtained mesoporous delivery systems with Zn-quercetin complex are promising as dermal formulations.

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Silver- and sulfadiazine-loaded nanostructured silica materials as potential replacement of silver sulfadiazine

Cited by 41 publications

References 37 publications

Solid-state encapsulation of Ag and sulfadiazine on zeolite Y carrier

Solid-state encapsulation of Ag and sulfadiazine on zeolite Y carrier

Preparation of efficient quercetin delivery system on Zn-modified mesoporous SBA-15 silica carrier

Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

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