Silver-based antibacterial strategies for healthcare-associated infections: Processes, challenges, and regulations. An integrated review

Bonilla-Gameros, Linda; Chevallier, Pascale; Sarkissian, A.

doi:10.1016/j.nano.2019.102142

Cited by 50 publications

(36 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some metal-based nanoparticles have natural antimicrobial activity and therefore show great potential for antimicrobial therapy [ 31 ]. Silver is one of the most effective and commonly used antibacterial materials, which can interfere with key functions in antimicrobial resistant microorganisms [ 32 , 33 ]. Silver breaks down the cell wall by interacting with the proteins of cell wall, inhibits cell division by interacting with DNA and RNA, interferes with signal transduction, and leads to the production of ROS [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Platelet membrane-camouflaged silver metal-organic framework drug system against infections caused by methicillin-resistant Staphylococcus aureus

Huang

Cai

et al. 2021

J Nanobiotechnol

View full text Add to dashboard Cite

Background Due to the intelligent survival strategy and self-preservation of methicillin-resistant Staphylococcus aureus (MRSA), many antibiotics are ineffective in treating MRSA infections. Nano-drug delivery systems have emerged as a new method to overcome this barrier. The aim of this study was to construct a novel nano-drug delivery system for the treatment of MRSA infection, and to evaluate the therapeutic effect and biotoxicity of this system. We prepared a nano silver metal-organic framework using 2-methylimidazole as ligand and silver nitrate as ion provider. Vancomycin (Vanc) was loaded with Ag-MOF, and nano-sized platelet vesicles were prepared to encapsulate Ag-MOF-Vanc, thus forming the novel platelet membrane-camouflaged nanoparticles PLT@Ag-MOF-Vanc. Results The synthesized Ag-MOF particles had uniform size and shape of radiating corona. The mean nanoparticle size and zeta potential of PLT@Ag-MOF-Vanc were 148 nm and − 25.6 mV, respectively. The encapsulation efficiency (EE) and loading efficiency (LE) of vancomycin were 81.0 and 64.7 %, respectively. PLT@Ag-MOF-Vanc was shown to be a pH-responsive nano-drug delivery system with good biocompatibility. Ag-MOF had a good inhibitory effect on the growth of three common clinical strains (Escherichia coli, Pseudomonas aeruginosa, and S. aureus). PLT@Ag-MOF-Vanc showed better antibacterial activity against common clinical strains in vitro than free vancomycin. PLT@Ag-MOF-Vanc killed MRSA through multiple approaches, including interfering with the metabolism of bacteria, catalyzing reactive oxygen species production, destroying the integrity of cell membrane, and inhibiting biofilm formation. Due to the encapsulation of the platelet membrane, PLT@Ag-MOF-Vanc can bind to the surface of the MRSA bacteria and the sites of MRSA infection. PLT@Ag-MOF-Vanc had a good anti-infective effect in mouse MRSA pneumonia model, which was significantly superior to free vancomycin, and has no obvious toxicity. Conclusions PLT@Ag-MOF-Vanc is a novel effective targeted drug delivery system, which is expected to be used safely in anti-infective therapy of MRSA. Graphic abstract

show abstract

Section: Introductionmentioning

confidence: 99%

Platelet membrane-camouflaged silver metal-organic framework drug system against infections caused by methicillin-resistant Staphylococcus aureus

Huang

Cai

et al. 2021

J Nanobiotechnol

View full text Add to dashboard Cite

show abstract

“…However, it must be remembered that they can possibly lead to adverse biological effects at the cellular levels. The toxicity of nanoparticles can vary depending on their size, morphology, surface area, surface reactivity, and solubility [87] and this means that future research should balance the safety with the effectiveness of 3D printed materials. The current three examples of utilizing CT scanning, segmentation, and additive manufacturing, to produce desperately needed replacement parts for compromised PAPRs is only the beginning of the possibilities that have been foreshadowed.…”

Section: Resultsmentioning

confidence: 99%

COVID-19 and a novel initiative to improve safety by 3D printing personal protective equipment parts from computed tomography

et al. 2020

View full text Add to dashboard Cite

Background: Powered air-purifying respirators are in short supply and can break down with extended use. Replacement parts can become hard to acquire. The aim of this study was to create an innovative quality improvement proof of concept using rapid prototyping. Methods: Here we report three cases of 3D printed powered air-purifying respirator parts. 3D printing was performed on all parts using fused deposition modeling with standard polylactic acid, in the same way that presurgical models would be created. Measurements using an electronic caliper as well as CT scans were used to compare an original part to its corresponding 3D printed parts for accuracy. Results: Electronic caliper and computed tomography measurements both showed accuracy consistant with current published norms. Conclusions: Ultimately, there will be questions surrounding intellectual property, effectiveness and potential longterm safety for these types of 3D printed parts. Future research should look into the addition of specific nanoparticles from the position of cost, efficacy, safety and improved accuracy.

show abstract

“…-увеличение отношения площади поверхности к объему [21,49,52]; -уменьшение размеров наночастиц [49]; -увеличение поверхностных дефектов [23]; -увеличение фотокаталитической активности оксидов металлов за счет уменьшения энергии запрещенной зоны при связывании с оксидом металла с меньшей шириной запрещенной зоны [22] или при легировании [45,68]. [14].…”

Section: стратегии по усилению антибактериального эффекта: легирование наночастиц оксидов металлов и создание нанокомпозитовunclassified

Аntibacterial inorganic agents: efficiency of using multicomponent systems

Мелешко¹,

Афиногенова²,

Афиногенов³

et al. 2020

Russian Journal of Infection and Immunity

View full text Add to dashboard Cite

Metal and metal oxide nanoparticles (NPs) are promising antibacterial agents exerting a broad antimicrobial activity against both Gram-positive and Gram-negative bacteria, viruses, and protozoans and allowing to avoid developing microbial resistance. Here we briefly review general mechanisms and the main NP factors affecting their antibacterial activity. Special attention is paid development of new-generation antimicrobial agents displaying augmented long-term bactericidal activity and low toxicity. We also describe examples of synthesizing double and triple nanocomposites based on the following oxides: CuO, ZnO, Fe3O4, Ag2O, MnO2 , etc. including metal and nonmetal doped nanocomposites (e.g. with Ag, Ce, Cr, Mn, Nd, Co, Sn, Fe, N, F etc.). Compared with bactericidal action of individual oxides, the nanocomposites demonstrate superior antibacterial activity and exert synergistic effects. For instance, the antimicrobial activity of ZnO against both Gram-positive and Gram-negative bacteria was increased by ∼100 % by formation of triple nanocomposites ZnO–MnO2–Cu2O or ZnO–Ag2O–Ag2S. Similar effect was showed for Ce-doped ZnO and Zn-doped CuO. We also highlight the examples of nanocomposites containing NPs and organic (chitosan, cellulose, polyvinylpyrrolidone, biopolymers etc.) or inorganic materials with special structure (graphene oxide, TiO2 nanotubes, silica) which demonstrate controlled release and long-term antibacterial activity. All of the nanocomposites and their combinations described have a pronounced long-term antimicrobial effect including that one against antibiotic-resistant microbial strains. They are able to prevent formation of microbial biofilms on biotic and abiotic surfaces, exhibit low toxicity to eukaryotic cells, demonstrate anti-inflammatory and wound-healing properties in contained with polymers (sodium alginate, collagen, polyvinylpyrrolidone etc.). The use of nanoscale systems can solve several important practical problems simultaneously by preserving long-term antimicrobial activities while reducing the number of constituents, generation of new antimicrobial agents with low toxicity and reduced environmental impact, development of new biocidal materials, including new coatings for effective antimicrobial protection of medical devices.

show abstract

Silver-based antibacterial strategies for healthcare-associated infections: Processes, challenges, and regulations. An integrated review

Cited by 50 publications

References 66 publications

Platelet membrane-camouflaged silver metal-organic framework drug system against infections caused by methicillin-resistant Staphylococcus aureus

Platelet membrane-camouflaged silver metal-organic framework drug system against infections caused by methicillin-resistant Staphylococcus aureus

COVID-19 and a novel initiative to improve safety by 3D printing personal protective equipment parts from computed tomography

Аntibacterial inorganic agents: efficiency of using multicomponent systems

Contact Info

Product

Resources

About