Silver‐Catalyzed and Silver‐Promoted Reactions of Isocyanides

Abstract

In recent years, the silver‐catalyzed and silver‐promoted isocyanide reactions have attracted much attention, due to its efficiency in the formation of diverse new bonds and good reaction selectivity. A series of highly useful linear or cyclic compounds have been constructed. In this review, the recent progress in this field is described in the sequence of synthesis of five‐membered heterocyclic compounds, synthesis of six‐membered heterocyclic compounds, synthesis of fused cyclic compounds as well as synthesis of linear nitrogen‐containing compounds.

Photoredox radical cyclization reaction of o-vinylaryl isocyanides with acyl chlorides to access 2,4-disubstituted quinolines

“…Isocyanides, due to their unique terminal carbon center, have been used as multifunctional components in organic synthesis for producing nitrogen-containing compounds, especially amides and heterocycles. 5 For example, isocyanides are isoelectronic with CO and have been applied as C 1 building blocks in transition-metal catalyzed insertion reactions, 6 which provide tremendous opportunities for the construction of fine chemicals containing a nitrogen functionality. Besides, isocyanide-based multicomponent reactions, 7 such as Ugi and Passerini reactions, are employed in the preparation of compound libraries of low-molecular druglike compounds.…”