Silver doped titanium oxide–PDMS hybrid coating inhibits Staphylococcus aureus and Staphylococcus epidermidis growth on PEEK

Tran, Nhiem; Kelley, Michael N.; Tran, Phong A.; Garcia, Dioscaris; Jarrell, John D.; Hayda, Roman A.; Born, Christopher T.

doi:10.1016/j.msec.2014.12.072

Cited by 41 publications

(46 citation statements)

References 39 publications

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“…Electrical currents are established when silver nanoparticles (cathode) embedded in a titanium matrix (anode) are exposed to electrolytes [45] -this galvanic coupling can cause changes in bacterial membrane morphology and DNA, leading to cell death [37] . Silver-based coatings have antimicrobial efficacy against a broad spectrum of pathogens, including Escherichia coli, S. aureus and S. epidermidis [46][47][48] . Using an in vivo model for osteomyelitis, Tran et al [48] inoculated S. aureus into fractured goat tibias and found after 5 wk silver-doped coated intramedullary nails led to better clinical and histology outcomes than the controls fixed with uncoated nails.…”

Section: Nano-silver Coatingsmentioning

confidence: 99%

Antimicrobial technology in orthopedic and spinal implants

Eltorai

Haglin

Perera

et al. 2016

WJO

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Infections can hinder orthopedic implant function and retention. Current implant-based antimicrobial strategies largely utilize coating-based approaches in order to reduce biofilm formation and bacterial adhesion. Several emerging antimicrobial technologies that integrate a multidisciplinary combination of drug delivery systems, material science, immunology, and polymer chemistry are in development and early clinical use. This review outlines orthopedic implant antimicrobial technology, its current applications and supporting evidence, and clinically promising future directions.Key words: Antimicrobial; Coated implants; Antibiotic; Antiseptic; Nano-silver; Photoactive Core tip: Infections can hinder orthopedic implant function and retention. Current implant-based antimicrobial strategies largely utilize coating-based approaches in order to reduce biofilm formation and bacterial adhesion. Several emerging antimicrobial technologies that integrate a multidisciplinary combination of drug delivery systems, material science, immunology, and polymer chemistry are in development and early clinical use. This review outlines the latest orthopedic implant antimicrobial technologies-including updates on chitosan

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Section: Nano-silver Coatingsmentioning

confidence: 99%

Antimicrobial technology in orthopedic and spinal implants

Eltorai

Haglin

Perera

et al. 2016

WJO

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“…A wide range of different implant materials are used in orthopedics. Despite the intensive research currently being performed on different technologies for incorporating antimicrobial agents [22][23][24][25][26][27][28][29][30][31][32], only a few studies investigating biofilm formation on different clinically relevant implantation materials have been published [33][34][35][36][37][38]. The dynamic changes associated with biofilm growth [39] make biofilm eradication from clinical materials even more challenging.…”

Section: Introductionmentioning

confidence: 99%

Structural and Functional Dynamics of Staphylococcus aureus Biofilms and Biofilm Matrix Proteins on Different Clinical Materials

et al. 2019

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Medical device-associated staphylococcal infections are a common and challenging problem. However, detailed knowledge of staphylococcal biofilm dynamics on clinically relevant surfaces is still limited. In the present study, biofilm formation of the Staphylococcus aureus ATCC 25923 strain was studied on clinically relevant materials—borosilicate glass, plexiglass, hydroxyapatite, titanium and polystyrene—at 18, 42 and 66 h. Materials with the highest surface roughness and porosity (hydroxyapatite and plexiglass) did not promote biofilm formation as efficiently as some other selected materials. Matrix-associated poly-N-acetyl-β-(1-6)-glucosamine (PNAG) was considered important in young (18 h) biofilms, whereas proteins appeared to play a more important role at later stages of biofilm development. A total of 460 proteins were identified from biofilm matrices formed on the indicated materials and time points—from which, 66 proteins were proposed to form the core surfaceome. At 18 h, the appearance of several r-proteins and glycolytic adhesive moonlighters, possibly via an autolysin (AtlA)-mediated release, was demonstrated in all materials, whereas classical surface adhesins, resistance- and virulence-associated proteins displayed greater variation in their abundances depending on the used material. Hydroxyapatite-associated biofilms were more susceptible to antibiotics than biofilms formed on titanium, but no clear correlation between the tolerance and biofilm age was observed. Thus, other factors, possibly the adhesive moonlighters, could have contributed to the observed chemotolerant phenotype. In addition, a protein-dependent matrix network was observed to be already well-established at the 18 h time point. To the best of our knowledge, this is among the first studies shedding light into matrix-associated surfaceomes of S. aureus biofilms grown on different clinically relevant materials and at different time points.

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“…Further surface treatments were also employed after the sulfonation process, such as chlorogenic acid/grafting peptide [ 43 ], graphene oxide coating [ 61 ] and hydrothermal treatment [ 48 ]. Incorporation of therapeutic and/or bioactive agents in the PEEK matrix or on the PEEK surface, such as simvastatin-PLLA [ 39 ]; Ag and Zn ions [ 37 , 39 , 40 , 58 ], dexamethasone plus minocycline-loaded liposomes [ 57 ], bioactive titanium dioxide (TiO 2 ) [ 52 ], 2-methacryloyloxyethyl phosphorylcholine [ 51 ] and titanium plasma [ 56 ]. PEEK coatings, such as the hybrid coating of titanium dioxide and polydimethylsiloxane [ 52 ]; chitosan/bioactive glass/lawsone [ 53 ], red and gray selenium nanoparticles [ 56 ], mussel-inspired polydopamine with silver nanoparticles incorporated and silk fibroin gentamicin sulfate [ 57 , 58 ].…”

Section: Strategies To Reduce Biofilm Formation In Peek Materials mentioning

confidence: 99%

Strategies to Reduce Biofilm Formation in PEEK Materials Applied to Implant Dentistry—A Comprehensive Review

et al. 2020

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Polyether-ether-ketone (PEEK) has emerged in Implant Dentistry with a series of short-time applications and as a promising material to substitute definitive dental implants. Several strategies have been investigated to diminish biofilm formation on the PEEK surface aiming to decrease the possibility of related infections. Therefore, a comprehensive review was carried out in order to compare PEEK with materials widely used nowadays in Implant Dentistry, such as titanium and zirconia, placing emphasis on studies investigating its ability to grant or prevent biofilm formation. Most studies failed to reveal significant antimicrobial activity in pure PEEK, while several studies described new strategies to reduce biofilm formation and bacterial colonization on this material. Those include the PEEK sulfonation process, incorporation of therapeutic and bioactive agents in PEEK matrix or on PEEK surface, PEEK coatings and incorporation of reinforcement agents, in order to produce nanocomposites or blends. The two most analyzed surface properties were contact angle and roughness, while the most studied bacteria were Escherichia coli and Staphylococcus aureus. Despite PEEK’s susceptibility to biofilm formation, a great number of strategies discussed in this study were able to improve its antibiofilm and antimicrobial properties.

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Silver doped titanium oxide–PDMS hybrid coating inhibits Staphylococcus aureus and Staphylococcus epidermidis growth on PEEK

Cited by 41 publications

References 39 publications

Antimicrobial technology in orthopedic and spinal implants

Antimicrobial technology in orthopedic and spinal implants

Structural and Functional Dynamics of Staphylococcus aureus Biofilms and Biofilm Matrix Proteins on Different Clinical Materials

Strategies to Reduce Biofilm Formation in PEEK Materials Applied to Implant Dentistry—A Comprehensive Review

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