Silver(I) complexes of 2,4-dihydroxybenzaldehyde–amino acid Schiff bases—Novel noncompetitive α-glucosidase inhibitors

Zheng, Jingwei; Ma, Lin

doi:10.1016/j.bmcl.2015.03.078

Cited by 27 publications

(9 citation statements)

References 18 publications

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“…Besides, it is obvious that complex 5 (IC 50 = 0.2376 μM) is the best α-glucosidase inhibitor compared with previous studies. [20,[37][38][39][40]57,106] Therefore, it can be stated that metal complexes containing the imine group tend to increase the inhibition of α-glucosidase.…”

Section: α-Glucosidase Inhibition Activitymentioning

confidence: 99%

“…However, metal ions at high concentrations are toxic, but metal complexes have many advantages such as highly selective combination with the active site of the enzyme and modulating the conformation of the enzyme by binding the residue near the active site of the enzyme. [20]…”

Section: α-Glucosidase Inhibition Activitymentioning

confidence: 99%

“…[11][12][13][14][15][16][17][18][19] The α-glucosidase inhibitory activity acts a significant role in the effect of oral antidiabetic drugs (OAD) therapy on non-insulin-dependent T2DM. [20] Miglitol, voglibose, genistein, and acarbose are commonly known and used types of α-glucosidase inhibitors. [10] The azomethine (imine) moiety (-C=N-) is one of the important groups of organic compounds and this group is widely used in the design and synthesis of molecules with biological properties.…”

Section: Introductionmentioning

confidence: 99%

“…It was determined that Zn 2+ , Cd 2+ , and Hg 2+ belonging to the 2B group encouraged glucosecarrying activity in rat adipocytes. [32] Some Ag(I) complexes containing imine group were synthesized as α-glucosidase inhibitors by Zheng and Ma in 2015 and 2016, [20,33] and it was reported that the -NH group and Ag(I) ion were very important for the inhibitory activity. In 2017, [4] the IC 50 value of the Zn complex containing N 2 O 2 was found at the mM level against α-glucosidase.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, DFT calculations, α‐glucosidase inhibitor activity, and docking studies on Schiff base metal complexes containing isothiocyanate

Özge

Avcı

Sönmez

et al. 2023

Applied Organom Chemis

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Diabetes is one of the fastest growing global health crises of the 21st century.One of the current therapeutic approaches used in the treatment of diabetes involves the suppression of carbohydrate hydrolyzing enzymes such as α-glucosidase. In this context, α-glucosidase inhibitors are important in the treatment and prevention of diabetes. For this reason, new Schiff base complexes 4), [Hg(L 1 ) 2 (NCS)Cl], (5); L 1 : N-(pyridin-2-ylmethylene)methanamine} were synthesized to investigate α-glucosidase inhibitor potentials. The IC 50 values of complexes 1-5 were found at 0.2376 ± 0.82 and 251.403 ± 2.54-μM range. Among these complexes, complex 5 has the highest α-glucosidase inhibitor property. The spectral investigations for the complexes 1/2-5 characterized by XRD/LC-HRMS were performed by UV-Vis and FT-IR spectra. Furthermore, the TD-DFT/DFT calculations were fulfilled by using CAM-B3LYP and ωB97XD/6-311+G(d,p)//LanL2DZ levels to obtain optimum complex structures, spectral, linear and nonlinear optical properties for 1-5. According to obtained theoretical nonlinear optical results, complex 3 is a strong indicator in terms of microscopic nonlinear optical (NLO) properties. The docking studies of these complexes were examined to display the target protein interactions with these complexes.

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Section: α-Glucosidase Inhibition Activitymentioning

confidence: 99%

Section: α-Glucosidase Inhibition Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis, DFT calculations, α‐glucosidase inhibitor activity, and docking studies on Schiff base metal complexes containing isothiocyanate

Özge

Avcı

Sönmez

et al. 2023

Applied Organom Chemis

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“…have been extensively synthesized because of being model compounds of a coenzyme of vitamin B6 [18][19][20][21][22]. These Schiff bases are one of the class of compounds possessing a broad spectrum of pharmacological activities such as antibacterial [23], antifungal [24], antiinflammatory [25], enzyme inhibition [26] and antioxidant activity [27]. Their metal complexes containing platinum [28], ruthenium [29], palladium [30], nickel [31] and lanthanum [32] have shown to be promising good antitumor, serum albumin and DNA-binding activities.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Cytotoxic Activity Studies in Series of Higher Amino Acid Schiff Bases

Özdemir

Gürkan

Demir

et al. 2020

Gazi University Journal of Science

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A new dinuclear copper (II) complex of 2,5–Furandicarboxyclic acid with 4(5)‐Methylimidazole as a high potential α‐glucosidase inhibitor: Synthesis, Crystal structure, Cytotoxicity study, and TD/DFT calculations

Avcı

Altürk

Sönmez

et al. 2019

Applied Organom Chemis

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A new dinuclear copper (II) complex of 2,5–furandicarboxyclic acid with 4(5)‐methylimidazole, [Cu (FDCA)((4(5)MeI)2]2·2H2O, was synthesized, and its structure characterized by XRD, FT–IR and UV–Vis spectroscopic techniques. The α‐glucosidase inhibition and cytotoxicity study of the synthesized Cu (II) complex were determined by IC50 values. The optimized geometry and vibrational harmonic frequencies for the Cu (II) complex were obtained by using Density Functional Theory (DFT) of HSEh1PBE/6–311++G(d,p)/LanL2DZ level. TD‐DFT/HSEh1PBE/6–311++G(d,p)/LanL2DZ level with CPCM model was applied to examine the electronic spectral properties and major contributions were determined via Swizard program. To investigate linear and nonlinear optical behavior of the synthesized Cu (II) complex, the α, Δα and χ(1)/β, γ and χ(3) parameters called linear/nonlinear optical parameters in gas phase and ethanol solvent were computed at the same level and basis set. Furthermore, molecular electrostatic potential (MEP) surface was determined by using the same level. The docking study of the Cu (II) complex to the binding site of the target protein (the template structure S. cerevisiae isomaltase) is fulfilled. Natural bond orbital (NBO) analysis was used to investigate the hyperconjugative interactions, inter‐ and intra‐molecular bonding and to determine coordination around Cu (II) ion. Finally, present work is the first remarkable scientific report of mixed‐ligand (H2FDCA and 4(5)MeI) Cu (II) complex as novel drug candidate for DM II. It is also determined that microscopic third−NLO parameters for the Cu (II) complex is remarkable.

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Silver(I) complexes of 2,4-dihydroxybenzaldehyde–amino acid Schiff bases—Novel noncompetitive α-glucosidase inhibitors

Cited by 27 publications

References 18 publications

Synthesis, DFT calculations, α‐glucosidase inhibitor activity, and docking studies on Schiff base metal complexes containing isothiocyanate

Synthesis, DFT calculations, α‐glucosidase inhibitor activity, and docking studies on Schiff base metal complexes containing isothiocyanate

Antioxidant and Cytotoxic Activity Studies in Series of Higher Amino Acid Schiff Bases

A new dinuclear copper (II) complex of 2,5–Furandicarboxyclic acid with 4(5)‐Methylimidazole as a high potential α‐glucosidase inhibitor: Synthesis, Crystal structure, Cytotoxicity study, and TD/DFT calculations

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