Silver/Iron Oxide Nano-Popcorns for Imaging and Therapy

Abstract

We have for the first time reported 120 nm silver/iron oxide hybrid nanopopcorns with surface plasmon resonance tuned at near-infrared (NIR) range for imaging and therapeutic applications. The nano-popcorns displayed excellent photothermal thrombolytic effect and anticancer activity in a concentration-dependent manner upon NIR laser irradiation, benefiting the photothermal treatment of thrombosis and cancer. At low concentrations, the nano-popcorns exhibited relatively good reactive oxygen species (ROS) scavenging capability. Notably, the nano-popcorns exerted excellent magnetic resonance imaging (MRI) T 2 -signal after being sequestered within cells or binding on the surface of the thrombus, becoming a promising imaging agent for cell labeling and thrombus detection. Cytotoxicity, biodistribution studies, and histology analysis demonstrated no significant toxicity caused by the nano-popcorns. There was no longterm retention of the nano-popcorns in the mouse organs at the dose treated. These results give insight into the potential of using these nano-popcorns for diagnosis and treatment of diseases related to ROS, cancer, and thrombosis.

Nanoscale Contrast Agents for Magnetic Resonance Imaging: A Review

“…Rehman et al designed nanopopcorns of silver/iron oxide hybrids with an excellent T 2 -weighted MRI signal and no noticeable toxicity for cell labeling and thrombus recognition applications. No long-term retention of these nanoagents could be detected in the organs of examined mice . Paramagnetic Fe­(III)-ion-chelated poly­(lactic acid- co -glycolic acid) NPs were formulated for MRI diagnostic applications .…”

“…These monodispersed nanomaterials with good biocompatibility exhibited selective release behavior, local delivery properties, and high drugloading capacity, providing immense opportunities for both imaging and drug-delivery applications. 85 Rehman et al 86 noticeable toxicity for cell labeling and thrombus recognition applications. No long-term retention of these nanoagents could be detected in the organs of examined mice.…”

“…No long-term retention of these nanoagents could be detected in the organs of examined mice. 86 Paramagnetic Fe(III)-ion-chelated poly(lactic acid-co-glycolic acid) NPs were formulated for MRI diagnostic applications. 87 The clinically relevant magnetic field relaxivity of these NCAs (∼130 ± 12 nm) with high monodispersity and stability, at physiological pH, of the NPs was 3 times higher than Magnevist.…”

Visualizing stem cells in vivo using magnetic resonance imaging

“…Iron oxide-based nanomaterials have been employed widely for imaging of various disease conditions (Arndt et al, 2020;Gaston et al, 2018;Yajun Liu et al, 2019;Rehman et al, 2021;H. Ta et al, 2010;Vazquez-Prada et al, 2020;Wu, Vazquez-Prada, et al, 2021;Yusof et al, 2019;Zia et al, 2020).…”

Pyridoxal-based low molecular weight progelator as a new chemosensor for the recognition of Ag+ and Hg2+ under different conditions

“…27 On the other hand, Ag + is a biologically important ion due to its antimicrobial activity. 28 It finds great application in organic synthesis, 29 catalysis, 30 electronic, 31 photography, 32 imaging industry, 33 etc. Recently, the application of LMWGs for the recognition of such toxic/heavy metal ions has attracted much interest owing to the simple naked eye detection involving sol-to-gel conversion or vice versa .…”