Silver lactate burn cream

Hoopes, J E; Butcher, H R; Margraf, Harry W.; Gravens, Daniel L.

doi:10.1097/00006534-197201000-00049

Cited by 2 publications

(3 citation statements)

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“…Recent investigations of nanoparticles report on their antimicrobial activity as well as the enhanced bioactivity of drugs. − Silver, a metal often employed for the preparation of NP, has been used for centuries as an antibacterial agent. Silver salts such as silver nitrate, silver lactate, and silver sulfadiazine have been employed to prevent bacterial infection, like in burn treatments, − in the formulation of dental resin composites, or as coatings of medical devices. − However, the exact action mechanism of silver as a bactericidal is not yet fully understood. , Silver ions are known to react with sulfhydrils and other chelating groups of proteins, which render these molecules inactive . They also seem to increase the permeability of lipid membranes, making the proton motive force collapse and leading eventually to cell death .…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6][7] Silver, a metal often employed for the preparation of NP, has been used for centuries as an antibacterial agent. Silver salts such as silver nitrate, silver lactate, and silver sulfadiazine have been employed to prevent bacterial infection, like in burn treatments, [8][9][10] in the formulation of dental resin composites, or as coatings of medical devices. [11][12][13] However, the exact action mechanism of silver as a bactericidal is not yet fully understood.…”

Section: ' Introductionmentioning

confidence: 99%

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Switchable Bactericidal Effects from Novel Silica-Coated Silver Nanoparticles Mediated by Light Irradiation

et al. 2011

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Here we report on the triggering of antibacterial activity by a new type of silver nanoparticle coated with porous silica, Ag@silica, irradiated at their surface plasmon resonant frequency. The nanoparticles are able to bind readily to the surface of bacterial cells, although this does not affect bacterial growth since the silica shell largely attenuates the intrinsic toxicity of silver. However, upon simultaneous exposure to light corresponding to the absorption band of the nanoparticles, bacterial death is enhanced selectively on the irradiated zone. Because of the low power density used for the treatments, we discard thermal effects as the cause of cell killing. Instead, we propose that the increase in toxicity is due to the enhanced electromagnetic field in the proximity of the nanoparticles, which indirectly, most likely through induced photochemical reactions, is able to cause cell death.

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Section: Introductionmentioning

confidence: 99%

Section: ' Introductionmentioning

confidence: 99%

Switchable Bactericidal Effects from Novel Silica-Coated Silver Nanoparticles Mediated by Light Irradiation

et al. 2011

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show abstract

“…Silver, a metal often employed for the preparation of NP, has been used for centuries as an antibacterial agent. Silver salts such as silver nitrate, silver lactate and silver sulfadiazine have been employed to prevent bacterial infection, like in burn treatments [8][9][10] , in the formulation of dental resin composites or as coatings of medical devices [11][12][13] . However, the exact action mechanism of silver as a bactericidal is not yet fully understood 14,15 .…”

Section: Introductionmentioning

confidence: 99%

Photoswitchable bactericidal effects from novel silica-coated silver nanoparticles

et al. 2011

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The enhancement of the electromagnetic field in the surroundings of nanoparticles via surface plasmon resonance offers promising possibilities for biomedical applications. Here we report on the selective triggering of antibacterial activity using a new type of silver nanoparticles coated with silica, Ag@silica, irradiated at their surface plasmon frequency. The nanoparticles are able to bind readily to the surface of bacterial cells, although this does not affect bacterial growing since the silica shell largely attenuates the intrinsic toxicity of silver. However, upon simultaneous exposure to light corresponding to the absorption band of the nanoparticles, bacterial death is triggered selectively on the irradiated zone. Because of the low power density used in the treatments, we discard thermal effects as the cause of cell killing. Instead, we propose that the switched toxicity is due to the enhanced electromagnetic field in the proximity of the nanoparticles, which either directly (through membrane perturbation) or indirectly (through induced photochemical reactions) is able to cause cell death.

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Silver lactate burn cream

Cited by 2 publications

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Switchable Bactericidal Effects from Novel Silica-Coated Silver Nanoparticles Mediated by Light Irradiation

Switchable Bactericidal Effects from Novel Silica-Coated Silver Nanoparticles Mediated by Light Irradiation

Photoswitchable bactericidal effects from novel silica-coated silver nanoparticles

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