Silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) nanofibers as wound dressings: a preclinical study

Li, Chenwen; Fu, Ruoqiu; Yu, Cai-ping; Li, Zhuoheng; Hai-yan, Guan; Hu, Dapeng; Zhao, Dehua; Lai-chun, LU

doi:10.2147/ijn.s51679

Cited by 80 publications

(33 citation statements)

References 26 publications

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“…At the same time, it can adhere to the wound surface and clot a ruptured wound [17,18]. Interestingly, the crosslinking efficiency increase by increasing the pH which maintains the compact structure of the ternary blend [19]. Amoxicillin with a ternary blend is the top candidate for wound healing and dressing applications and can determine swelling degree which permits to predict exudate ability.…”

Section: Swelling Studiesmentioning

confidence: 99%

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Microbial activity and swelling behavior of chitosan/polyvinyl alcohol/sodium alginate semi-natural terpolymer interface containing amoxicillin for wound dressing applications

2019

Biointerface Res Appl Chem

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Samples of equimass fraction chitosan/polyvinyl alcohol/sodium alginate semi-natural terpolymer with and without gradient concentration of amoxicillin, a topical antibiotic drug were prepared via traditional casting techniques. Changing in antibacterial activity and swelling degree have been assessed using the zone of inhibition method and pH sensitivity study. Upon increasing the amoxicillin concentration, the enhancement of antibacterial activity was performed against (2g) positive bacteria (S. aureus, B. subtilis), (2g) negative bacteria (E. coli, P. aeuroginosa) and fungus (C. albicans). Increasing the concentration of amoxicillin caused a decreasing in the swelling ratio (SR) at neutral (pH= 7) and basic medium (pH= 8, 9) due to increase cross-linked and rigidity of the network. Hence the results strongly support the possibility of using this novel Cs/PVA/SA with different amounts of amoxicillin to compatible used in tissue regeneration and antimicrobial applications.

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Section: Swelling Studiesmentioning

confidence: 99%

“…This preserves Amox within the blend for prolonged periods (prolong time action of the drug) and get the ability to determine water uptake. Moreover, the swelling ability decreases due to the crosslinking degree hinder the disentanglements of the chain and intermolecular motion in the polymer blend [19,20].…”

Section: Swelling Studiesmentioning

confidence: 99%

Microbial activity and swelling behavior of chitosan/polyvinyl alcohol/sodium alginate semi-natural terpolymer interface containing amoxicillin for wound dressing applications

2019

Biointerface Res Appl Chem

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“…However, Kora and Rastogi (2013) AgNPs treated with different protective agents, which resulted in different particle-aggregation states conferring differing antibacterial activities. Chitosan is the second most abundant natural nontoxic biomaterial, and chitosan-AgNPs show considerably stronger antimicrobial properties against E. coli and S. aureus (Li et al, 2013). The cationic protective agent chitosan is beneficial in terms of promoting AgNP adsorption on negative-electrode membrane proteins and can effectively improve the antibacterial activity of AgNPs (Sotiriou & Pratsinis, 2010).…”

Section: Surface-coating-dependent Toxicity Of Silver Nanoparticlesmentioning

confidence: 99%

Review of the effects of silver nanoparticle exposure on gut bacteria

Tang

Yang

2018

J of Applied Toxicology

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Gut bacteria are involved in regulating several important physiological functions in the host, and intestinal dysbacteriosis plays an important role in several human diseases, including intestinal, metabolic and autoimmune disorders. Although silver nanoparticles (AgNPs) are increasingly being incorporated into medical and consumer products due to their unique physicochemical properties, studies have indicated their potential to affect adversely the gut bacteria. In this review, we focus on the biotoxicological effects of AgNPs entering the gastrointestinal tract and the relationship of these effects with important nanoscale properties. We discuss in detail the mechanisms underlying the bactericidal toxicity effects of AgNPs and explore the relationships between AgNPs, gut bacteria and disease. Finally, we highlight the need to focus on the negative effects of AgNPs usage to facilitate appropriate development of these particles.

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“…The basic science of electrospinning and several techniques enabling the efficient preparation of nanofibers were reported in the early part of this century. Electrospun nanofibers have been applied to various fields that can leverage their characteristic properties (high surface area, adjustable pore volume, and broad range of material types)567, such as tissue engineering89101112131415, sensors1617, drug delivery181920, wound dressing2122232425, and energy applications262728.…”

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confidence: 99%

Syringeless Electrospinning toward Versatile Fabrication of Nanofiber Web

Moon

Gil

Lee

2017

Sci Rep

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Although electrospinning is considered a powerful and generic tool for the preparation of nanofiber webs, several issues still need to be overcome for real-world applications. Most of these issues stem from the use of a syringe-based system, where the key factor influencing successful electrospinning is the maintenance of several subtle balances such as those of between the mass and the electrical state. It is extremely difficult to maintain these balances throughout the spinning process until all the polymeric solution in the syringe has been consumed. To overcome these limitations, we have developed a syringeless electrospinning technique as an alternative and efficient means of preparing a nanofiber web. This new technique uses a helically probed rotating cylinder. This technique can not only cover conventional methods, but also provides several advantages over syringe-based and needless electrospinning in terms of productivity (6 times higher) and processibility. For example, we can produce nanofibers with highly crystalline polymers and nanofiber-webs comprising networks of several different polymers, which is sometimes difficult in conventional electrospinning. In addition, this method provides several benefits for colloidal electrospinning as well. This method should help expand the range of applications for electrospun nanofiber webs in the near future.

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Silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) nanofibers as wound dressings: a preclinical study

Cited by 80 publications

References 26 publications

Microbial activity and swelling behavior of chitosan/polyvinyl alcohol/sodium alginate semi-natural terpolymer interface containing amoxicillin for wound dressing applications

Microbial activity and swelling behavior of chitosan/polyvinyl alcohol/sodium alginate semi-natural terpolymer interface containing amoxicillin for wound dressing applications

Review of the effects of silver nanoparticle exposure on gut bacteria

Syringeless Electrospinning toward Versatile Fabrication of Nanofiber Web

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