Silver nanoparticle-decorated 2D Co-TCPP MOF nanosheets for synergistic photodynamic and silver ion antibacterial

Li, Xiangqian; Zhao, Xinshuo; Chu, Dandan; Lee, Seonjoo; Xue, Baoli; Chen, Hong; Zhou, Zhan; Li, Jingguo

doi:10.1016/j.surfin.2022.102247

Cited by 30 publications

(25 citation statements)

References 51 publications

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“…aureus cells treated with or without 25 μM PPNM solution were fixed in centrifuge tubes containing 4% polyoxymethylene at room temperature for 15 min then dehydrated in an ascending series of ethanol, transferred to cleaned silicon wafers, and dried under vacuum. Finally, the samples were gold sputter-coated and imaged using a scanning electron microscope …”

Section: Methodsmentioning

confidence: 99%

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Antibiotic-free Self-assembled Polypeptide Nanomicelles for Bacterial Keratitis

Cheng

Cui

Zhang

et al. 2022

ACS Appl. Polym. Mater.

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Drug resistance of bacteria limits the effectiveness of traditional antibiotics for bacterial keratitis. Antimicrobial peptides with a broad-spectrum antibacterial activity and bactericidal mechanism of membrane disruption provide an alternative for the treatment of bacterial keratitis. In the present study, an antimicrobial peptide polymer was developed and self-assembled into polypeptide nanomicelles (PPNMs) for treatment of bacterial keratitis. The self-assembly process led to spherical shapes with a diameter of around 45 nm and a relatively narrow size distribution. The nanomicelles also exhibited a positive charge and excellent biocompatibility. Antimicrobial tests have shown that PPNMs possessed a mechanism of action to destroy bacterial membranes and were superior to tobramycin in the treatment of bacterial keratitis. Therefore, we expect PPNMs to have good potential as an antimicrobial drug.

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Section: Methodsmentioning

confidence: 99%

“…Finally, the samples were gold sputter-coated and imaged using a scanning electron microscope. 35 2.7. In Vivo Antibacterial Assay.…”

Section: Minimum Inhibitory Concentration (Mic)mentioning

confidence: 99%

Antibiotic-free Self-assembled Polypeptide Nanomicelles for Bacterial Keratitis

Cheng

Cui

Zhang

et al. 2022

ACS Appl. Polym. Mater.

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“…To prepare the SEM specimens, the bacterial suspensions obtained after treatment were washed with PBS. Subsequently, they were fixed overnight with a 2.5% glutaraldehyde solution and dehydrated using sequential ethanol solutions (30,40,50,70,80, 90, and 100%) for 10 min each. After drying in a vacuum chamber, all specimens were imaged using FE-SEM (SUPRA 55VP, Carl Zeiss, Germany) at an accelerating voltage of 2 kV.…”

Section: ■ Conclusionmentioning

confidence: 99%

“…For example, AgNP-decorated two-dimensional (2D) porphyrinic MOF nanosheets were fabricated by Ag reduction on the MOF via a reducing agent (i.e., sodium borohydride) for photoactive releases of reactive oxygen species (ROS) and Ag ions. 40 Ag@MOF-5 was also fabricated using the hydrothermal method with H 2 and presented as an antimicrobial agent with enhanced photoactive ROS release and dispersibility. 41 Ag-doped carbonized zeolitic imidazolate framework (ZIF) nanocomposites formed by doping AgNPs onto the Zn-MOF surface under Ar gas condition exhibited simultaneous functions as antibacterial and PTT reagents.…”

Section: ■ Introductionmentioning

confidence: 99%

Photoactive MOF-Derived Bimetallic Silver and Cobalt Nanocomposite with Enhanced Antibacterial Activity

Kim

Park

et al. 2023

ACS Appl. Mater. Interfaces

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Conventional antibiotic-based treatment of bacterial infections remains one of the most difficult challenges in medicine because of the threat of multidrug resistance caused by indiscriminate abuse. To solve these problems, it is essential to develop an effective antibacterial agent that can be used at a small dose while minimizing the occurrence of multiple resistance. Metal–organic frameworks (MOFs), which are hyper-porous hybrid materials containing metal ions linked by organic ligands, have recently attracted attention because of their strong antibacterial activity through metal-ion release, unlike conventional antibiotics. In this study, we developed a photoactive MOF-derived cobalt–silver bimetallic nanocomposite (Ag@CoMOF) by simply depositing silver nanoparticles on a cobalt-based MOF through nanoscale galvanic replacement. The nanocomposite structure continuously releases antibacterial metal ions (i.e., Ag and Co ions) in the aqueous phase and exhibits a strong photothermal conversion effect of Ag nanoparticles, accompanied by a rapid temperature increase of 25–80 °C under near-infrared (NIR) irradiation. Using this MOF-based bimetallic nanocomposite, superior antibacterial activities were achieved by 22.1-fold for Escherichia coli and 18.3-fold for Bacillus subtilis enhanced inhibition of bacterial growth in a liquid culture environment compared with the generally used chemical antibiotics. In addition, we confirmed the synergistic enhancement of the antibacterial ability of the bimetallic nanocomposite induced by NIR-triggered photothermal heating and bacterial membrane disruption even when using a small amount of the nanocomposites. We envision that this novel antibacterial agent using MOF-based nanostructures will replace traditional antibiotics to circumvent multidrug resistance and present a new approach to antibiotic development.

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“…As an innovative therapy for cancer, PTT has attracted great research enthusiasm in recent years for its use of external stimulation to convert light energy into local heat therapy while minimizing side effects. [201][202][203] PTT is minimally invasive, highly efficacious, and can eliminate tumors in a safer way as compared with conventional methods (chemotherapy and surgery). In the past decade, Mo-NMs have become competitive and potential photothermal nanoagents due to their strong NIR absorption, high PCE, and biological safety.…”

Section: Pttmentioning

confidence: 99%

Molybdenum‐Based Nanomaterials for Photothermal Cancer Therapy

Zhou

et al. 2022

Advanced NanoBiomed Research

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Figure 2. Preparation of Mo-based NMs via ultrasound-assisted liquid-phase exfoliation strategy. A) Monolayer molybdenum dichalcogenides (MoS 2 andMoSe 2 ) nanosheets possess superior biomedical stability and high photothermal conversion effect. Reproduced with permission. [147] Copyright 2018, American Chemical Society. B) Single layer of MoSe 2 nanosheets as a novel PAI/PTT theranostic nanoagent. Reproduced with permission. [143] Copyright 2018, Royal Society of Chemistry. C) Hydrophobic MoSe 2 nanosheets as a photothermal-chemotherapeutic agent. Reproduced with permission. [149] Copyright 2020, Royal Society of Chemistry. D) Oxygen-deficient α-MoO 3Àx nanoflakes exhibit high biocompatibility and physiological stability. Reproduced with permission. [150] Copyright 2018, Wiley-VCH.

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Silver nanoparticle-decorated 2D Co-TCPP MOF nanosheets for synergistic photodynamic and silver ion antibacterial

Cited by 30 publications

References 51 publications

Antibiotic-free Self-assembled Polypeptide Nanomicelles for Bacterial Keratitis

Antibiotic-free Self-assembled Polypeptide Nanomicelles for Bacterial Keratitis

Photoactive MOF-Derived Bimetallic Silver and Cobalt Nanocomposite with Enhanced Antibacterial Activity

Molybdenum‐Based Nanomaterials for Photothermal Cancer Therapy

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