Silver nanoparticle-induced hormesis of astroglioma cells: A Mu-2-related death-inducing protein-orchestrated modus operandi

Choi, Jun-Ha; Min, Wan-Kwon; Gopal, Judy; Lee, Yoon-Mi; Muthu, Manikandan; Chun, Sechul; Oh, Jae-Wook

doi:10.1016/j.ijbiomac.2018.05.234

Cited by 12 publications

(4 citation statements)

References 32 publications

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“…The concept of hormesis, as an adaptive response of biological systems to cope with environmental challenges, has raised considerable interest with respect to nanotoxicology in view of the rapid pace of the production and application of increasingly innovative nanomaterials and the expected increased likelihood of environmental and human exposure to low-dose concentrations 25,26. For example, Choi et al reported that a low dose of silver NPs (AgNPs) could induce hormesis in astroglioma cells27 and lung epithelial cells 28. We hypothesize that the increase in the cell viability of macrophages induced by low concentrations of QDs might be the result of hormesis.…”

Section: Discussionmentioning

confidence: 99%

<p>InP/ZnS Quantum Dots Cause Inflammatory Response in Macrophages Through Endoplasmic Reticulum Stress and Oxidative stress</p>

Chen¹,

Chen²,

Chen³

et al. 2019

IJN

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PurposeQuantum dots (QDs) are widely used semiconductor nanomaterials. Indium phosphide/zinc sulfide (InP/ZnS) QDs are becoming potential alternatives to toxic heavy metal-containing QDs. However, the potential toxicity and, in particular, the immunotoxicity of InP/ZnS QDs are unknown. This study aimed to investigate the impacts of InP/ZnS QDs on inflammatory responses both in vivo and in vitro.MethodsMice and mouse bone marrow-derived macrophages (BMMs) were exposed to polyethylene glycol (PEG) coated InP/ZnS QDs. The infiltration of neutrophils and the release of interleukin-6 (IL-6) were measured using a hematology analyzer and an enzyme-linked immunosorbent assay (ELISA) for the in vivo test. Cytotoxicity, IL-6 secretion, oxidative stress and endoplasmic reticulum (ER) stress were studied in the BMMs, and then, inhibitors of oxidative stress and ER stress were used to explore the mechanism of the InP/ZnS QDs.ResultsWe found that 20 mg/kg PEG-InP/ZnS QDs increased the number of neutrophils and the levels of IL-6 in both peritoneal lavage fluids and blood, which indicated acute phase inflammation in the mice. PEG-InP/ZnS QDs also activated the BMMs and increased the production of IL-6. In addition, PEG-InP/ZnS QDs triggered oxidative stress and the ER stress-related PERK-ATF4 pathway in the BMMs. Moreover, the inflammatory response caused by the PEG-InP/ZnS QDs could be attenuated in the macrophages by blocking the oxidative stress or the ER stress with inhibitors.ConclusionInP/ZnS QDs can activate macrophages and induce acute phase inflammation both in vivo and in vitro, which may be regulated by oxidative stress and ER stress. Our present work is expected to help clarify the biosafety of InP/ZnS QDs and promote their safe application in biomedical and engineering fields.

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Section: Discussionmentioning

confidence: 99%

<p>InP/ZnS Quantum Dots Cause Inflammatory Response in Macrophages Through Endoplasmic Reticulum Stress and Oxidative stress</p>

Chen¹,

Chen²,

Chen³

et al. 2019

IJN

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“…Consistent with this, it has been recently demonstrated that silver nanoparticles (AgNPs) induce hormesis in astroglioma cells and the potential involvement of Mu-2-related death-inducing gene (MuD) in AgNP-induced hormesis. Therefore, AgNPs at low doses exhibited cytotoxic effects on astroglioma cell proliferation in a dose-dependent manner by increasing MuD expression resulting in anticancer effects of brain tumors [190]. Ferroptosis is a form of nonapoptotic cell death that is dependent on iron.…”

Section: Hormesis and Nanochemopreventive Approach By Polyphenols For...mentioning

confidence: 99%

Redox modulation by plant polyphenols targeting vitagenes for chemoprevention and therapy: Relevance to novel anti-cancer interventions and mini-brain organoid technology

Scuto

Ontario

Salinaro

et al. 2022

Free Radical Biology and Medicine

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“…In yet another interesting study Oh et al have established that MuD possesses anti-apoptotic functions and is involved in silver nanoparticle (AgNP)-induced astroglioma hormesis [ 105 ]. Their investigations on whether silver nanoparticles (AgNPs) induce hormesis in astroglioma cells, towards probing the possible involvement of MuD in AgNP-induced hormesis, has thrown more light on the functionality of MuD.…”

Section: Evolution Of Mudengmentioning

confidence: 99%

The MUDENG Augmentation: A Genesis in Anti-Cancer Therapy?

Muthu

Chun

Gopal

et al. 2020

IJMS

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Despite multitudes of reports on cancer remedies available, we are far from being able to declare that we have arrived at that defining anti-cancer therapy. In recent decades, researchers have been looking into the possibility of enhancing cell death-related signaling pathways in cancer cells using pro-apoptotic proteins. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and Mu-2/AP1M2 domain containing, death-inducing (MUDENG, MuD) have been established for their ability to bring about cell death specifically in cancer cells. Targeted cell death is a very attractive term when it comes to cancer, since most therapies also affect normal cells. In this direction TRAIL has made noteworthy progress. This review briefly sums up what has been done using TRAIL in cancer therapeutics. The importance of MuD and what has been achieved thus far through MuD and the need to widen and concentrate on applicational aspects of MuD has been highlighted. This has been suggested as the future perspective of MuD towards prospective progress in cancer research.

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Silver nanoparticle-induced hormesis of astroglioma cells: A Mu-2-related death-inducing protein-orchestrated modus operandi

Cited by 12 publications

References 32 publications

<p>InP/ZnS Quantum Dots Cause Inflammatory Response in Macrophages Through Endoplasmic Reticulum Stress and Oxidative stress</p>

<p>InP/ZnS Quantum Dots Cause Inflammatory Response in Macrophages Through Endoplasmic Reticulum Stress and Oxidative stress</p>

Redox modulation by plant polyphenols targeting vitagenes for chemoprevention and therapy: Relevance to novel anti-cancer interventions and mini-brain organoid technology

The MUDENG Augmentation: A Genesis in Anti-Cancer Therapy?

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