Silver nanoparticles: Advanced and promising technology in diabetic wound therapy

Choudhury, Hira; Pandey, Manisha; Lim, Yan Qing; Low, Chea Yee; Lee, Cheng Teck; Marilyn, Tee Cheng Ling; Loh, Huai Seang; Lim, Yee Ping; Lee, Cheng Feng; Bhattamishra, Subrat Kumar; Kesharwani, Prashant; Gorain, Bapi

doi:10.1016/j.msec.2020.110925

Cited by 137 publications

(91 citation statements)

References 111 publications

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“… 30 In diabetic patients, the imbalance between angiogenic factors (eg, transforming growth factor-β, TGF-β; fibroblast growth factor 2, FGF2; vascular endothelial growth factor, VEGF; angiopoietins) and angiostatic factors (eg, thrombospondins, endostatin, angiostatin) may lead to angiogenic imbalance and aggravate wound hypoxia. 31 Likewise, hypoxia can amplify the inflammatory response, thereby prolonging injury by increasing the levels of oxygen radicals. 32 Two main events for effective wound healing involve an inflammatory response and migration of keratinocytes, fibroblasts, and endothelial cells.…”

Section: Introductionmentioning

confidence: 99%

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

Bai¹,

Han²,

Dong³

et al. 2020

IJN

159

114

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Diabetic wound shows delayed and incomplete healing processes, which in turn exposes patients to an environment with a high risk of infection. This article has summarized current developments of nanoparticles/hydrogels and nanotechnology used for promoting the wound healing process in either diabetic animal models or patients with diabetes mellitus. These nanoparticles/hydrogels promote diabetic wound healing by loading bioactive molecules (such as growth factors, genes, proteins/peptides, stem cells/exosomes, etc.) and nonbioactive substances (metal ions, oxygen, nitric oxide, etc.). Among them, smart hydrogels (a very promising method for loading many types of bioactive components) are currently favored by researchers. In addition, nanoparticles/hydrogels can be combined with some technology (including PTT, LBL self-assembly technique and 3D-printing technology) to treat diabetic wound repair. By reviewing the recent literatures, we also proposed new strategies for improving multifunctional treatment of diabetic wounds in the future.

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Section: Introductionmentioning

confidence: 99%

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

Bai¹,

Han²,

Dong³

et al. 2020

IJN

159

114

View full text Add to dashboard Cite

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“…Physiological management of chronic wounds could effectively be managed by topical therapies, where control of acidic pH, proper level of moisture, formation of biofilms by the pathogenic bacterial growth and temperature need to be maintained using a biocompatible environment [ 5 ]. However, numerous researches are ongoing in different parts of the world to develop successful wound dressings towards acceleration of the healing process [ 6 , 7 , 8 ]. It is important to mention that a suitable wound healing material should possess certain characteristics, viz.…”

Section: Introductionmentioning

confidence: 99%

Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy in Wound Healing

et al. 2020

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The potential role of naringenin (NAR), a natural flavonoid, in the treatment of chronic wound has prompted the present research to deliver the drug in nanoemulsion (NE) form, where synergistic role of chitosan was achieved through development of chitosan-coated NAR NE (CNNE). The NE consisted of Capryol 90, Tween 20 and Transcutol P, which was fabricated by low-energy emulsification method to encapsulate NAR within the oil core. The optimization of the formulated NEs was performed using Box–Behnken statistical design to obtain crucial variable parameters that influence globule size, size distribution and surface charge. Finally, the optimized formulation was coated with different concentrations of chitosan and subsequently characterized in vitro. The size of the CNNE was found to be increased when the drug-loaded formulation was coated with chitosan. Controlled release characteristics depicted 67–81% release of NAR from the CNNE, compared to 89% from the NE formulation. Cytotoxicity study of the formulation was performed in vitro using fibroblast cell line (NIH-3T3), where no inhibition in proliferation of the cells was observed with CNNE. Finally, the wound healing potential of the CNNE was evaluated in an abrasion-created wound model in experimental animals where the animals were treated and compared histologically at 0 and 14 days. Significant improvement in construction of the abrasion wound was observed when the animals were treated with formulated CNNE, whereas stimulation of skin regeneration was depicted in the histological examination. Therefore, it could be summarized that the chitosan coating of the developed NAR NE is a potential platform to accelerate healing of wounds.

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“…Among biodegradable and natural-based polymers [4], sodium alginate fibers have applications in preparation of wound care dressings [23,24]. Combination of alginate with AgNPs could result in an enhancement in healing properties while broadening the antimicrobial spectrum of wound dresses [25,26].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel reducing agent for formation of metronidazole-capped silver nanoparticle and evaluating antibacterial efficiency in gram-positive and gram-negative bacteria

Farjadian

Akbarizadeh

Tayebi

2020

Heliyon

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In this study, a new type of silver nanoparticles capped with metronidazolium based ionic liquid is synthesized. By this aim, metronidazole is altered to ionic-liquid type structure with citrate counter ion as reducing agent. The produced reducing agent was characterized using 1 HNMR and 13 CNMR and FT-IR. The capability of metronidazolium-based reducing agent in formation and capping silver nanoparticles was examined in a chemical reaction. More specifically, synthesized silver nanoparticles were synthesized and capped with metronidazoliumcitrate based ionic liquid, while the formation of particles in 48 h was monitored by UV-Vis spectroscopy. Fourier transform infrared spectroscopy showed the presence of capping agents around silver nanoparticles. The amount of metronidazolium and citrate as capping agents was determined by thermal gravimetric analysis. The prepared crystalline structure of silver nanoparticles was proved by X-ray diffraction spectroscopy. PSA analysis and TEM was performed to determine the size of particles. The synthesized silver nanoparticle has the potential to be used as an antibacterial agent in preparation of wound dressing with extra capability and efficacy in aerobic and anaerobic bacterium. In this regard, the antibacterial efficacy of discs from different concentration of silver nanoparticles in calcium alginate medium were evaluated in Gram-negative and Gram-positive bacterium.

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Silver nanoparticles: Advanced and promising technology in diabetic wound therapy

Cited by 137 publications

References 111 publications

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy in Wound Healing

Synthesis of novel reducing agent for formation of metronidazole-capped silver nanoparticle and evaluating antibacterial efficiency in gram-positive and gram-negative bacteria

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