Silver nanoparticles as a potential antimicrobial additive for weaned pigs

Fondevila, M.; Herrer, R.; Casallas, M.C.; Abecia, Leticia; Ducha, Javier

doi:10.1016/j.anifeedsci.2008.09.003

Cited by 166 publications

(127 citation statements)

References 37 publications

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“…This lack of treatment effect is consistent with findings in quail, pigs, and chickens and supports the conclusion that AgNano do not affect growth [7,20,[23][24][25]. Interestingly, the difference in fat uptake between treatments was not reflected in hatchling development.…”

Section: Hatchling Developmentsupporting

confidence: 80%

Investigating the Effect of In Ovo Injection of Silver Nanoparticles on Fat Uptake and Development in Broiler and Layer Hatchlings

Pineda

Chwalibog

Sawosz

et al. 2012

Journal of Nanotechnology

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Silver nanoparticles (AgNano) as carrier of available oxygen (O 2 ) and with high surface reactivity may increase O 2 consumption, enhance fat uptake (FU), and stimulate growth and development. The objective was to investigate the effects of in ovo injection of AgNano on the metabolic rate (O 2 consumption, CO 2 production, and heat production, HP), fat uptake, and the development of broiler and layer hatchlings. AgNano concentrations (50, 75, and 100 mg/kg) were injected in ovo at day 1 of incubation to different breeds of broiler and layer chicken embryos. Oxygen consumption and subsequently FU did not increase linearly following AgNano treatment. FU was lower in hatchlings treated with 50 and 100 mg AgNano/kg, but surprisingly not in hatchlings treated with 75 mg AgNano/kg. Interestingly, the difference in FU between treatments was not reflected in hatchling development. The results indicated that AgNano affected metabolic rate and FU; however, it did not influence the development of hatchlings. This suggests that in ovo injection of AgNano reduces the need to use yolk fat as an energy source during embryonic development and consequently the remaining fat in the residual yolk sac may provide a potent source of nutritional reserves for chicks of few days after hatching.

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Section: Hatchling Developmentsupporting

confidence: 80%

Investigating the Effect of In Ovo Injection of Silver Nanoparticles on Fat Uptake and Development in Broiler and Layer Hatchlings

Pineda

Chwalibog

Sawosz

et al. 2012

Journal of Nanotechnology

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“…According to these results, metallic silver nanoparticles would reduce the viability of organisms with a potentially harmful effect, such as coliforms, whereas it does not affect lactobacilli, which positively compete against pathogens proliferation and reduce their virulence (Blomberg et al, 1993). A trend (P = 0.07) to a coliform reduction in ileal contents was also observed in vivo by Fondevila et al (2009) when 20 and 40 ppm of metallic silver nanoparticles were given to weaned piglets as metallic silver adsorbed in a sepiolite matrix (ARGENTA, Laboratorios Argenol S.L., Spain) as antimicrobial and growth promoter for weaned pigs during their transition phase (from 5 to 20 kg weight). Besides, although concentration of major bacterial groups in the ileum of pigs were not markedly affected, the concentration of the pathogen Clostridium perfringens/ Cl.…”

Section: Potential Use Of Silver In Animal Feedingmentioning

confidence: 99%

“…However, the availability of results testing metallic silver nanoparticles in animal production experiments is very scarce. It has been observed in vitro that the proportion of coliforms in pigs ileal contents was linearly reduced (P<0.05), whereas no effect was observed on lactobacilli proportion, when the concentration of colloidal silver in the medium increased from 0 to 25, 50 or 100 ppm (Fondevila et al, 2009). According to these results, metallic silver nanoparticles would reduce the viability of organisms with a potentially harmful effect, such as coliforms, whereas it does not affect lactobacilli, which positively compete against pathogens proliferation and reduce their virulence (Blomberg et al, 1993).…”

Section: Potential Use Of Silver In Animal Feedingmentioning

confidence: 99%

“…Inclusion of 2500 to 3000 ppm zinc in diets for post-weaning pig leads to tissue retention from 220 µg/g (Jensen-Waern et al, 1998;Carlson et al, 1999) to 445 µg/g (Zhang & Guo, 2007) in liver, and retentions up to 3020 µg/g have been reported (Case and Carlson, 2002). In a study carried out with metallic silver, no silver retention was detected in renal or muscular (semimembranous) tissue in weaned piglets given 20 or 40 ppm silver for 35 days (n=18), and only 0.435 and 0.837 µg per g were recorded in liver (Fondevila et al, 2009). Another experiment repeated in the same conditions (Gonzalo, Latorre & Fondevila, unpublished) showed minimal silver retention in muscles (0.036 and 0.033 µg/g with 20 and 40 ppm silver in diet) and kidney (0.034 and 0.039 µg/g, respectively) that was observed in 6 out of 8 animals, whereas silver was detected in liver of all animals at 0.400 and 0.557 µg/g for 20 and 40 ppm, respectively.…”

Section: Potential Use Of Silver In Animal Feedingmentioning

confidence: 99%

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Potential Use of Silver Nanoparticles as an Additive in Animal Feeding

Fondevila¹

2010

Silver Nanoparticles

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Among other uses, metallic silver and silver salts have currently been applied as antimicrobial agents in many aspects of medical industries, such as coating of catheters, dental resin composites and burn wounds, as well as in homeopathic medicine, with a minimal risk of toxicity in humans. However, their use in animal feeding as prebiotics have remain minimised, mostly because of the low cost antibiotics used as growth promoters in the second half of the XX Century. However, after the ban of this practice in the European Community, silver compounds appear as a potential alternative to other already in use, such as organic acids, oligosaccharides, plant extracts, etc. The major concerns about the safe use of an additive in animal feeding are its effective role as antimicrobial, acting selectively over potential pathogens but not over symbiotic microbial communities; a low toxic effect over the animal and its human consumer; and a low risk of environmental pollution. Metallic silver nanoparticles (up to 100 nm) allow for a higher antimicrobial effect than silver salts, are more resistant to deactivation by gastric acids and have a low absorption rate through the intestinal mucosa, thus minimising its potential risk of toxicity. Besides, it has been shown that the doses that promote animal physiological and productive effects are very low (20 to 40 ppm), especially compared to the 10 to 100-fold higher concentration used with other metallic compounds such as copper and zinc, thus precluding a harmful environmental effect. This chapter describes the reasons why silver nanoparticles could be applied to animal feeding, and provides with some available data in this regard. In any case, its registration as feed additive is a previous requisite before being applied in practical conditions.

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“…In addition, additives containing AgNPs have been considered in domestic animal diets. 7 However, the efficacy of AgNPs or their derivatives for controlling microbial infections in the digestive tract of animals has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of nanohybrids comprising silver nanoparticles and silicate clay for controlling Salmonella infection

Chiao¹,

Lin²,

Shen³

et al. 2012

IJN

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Developing effective and safe drugs is imperative for replacing antibiotics and controlling multidrug-resistant microbes. Nanoscale silicate platelet (NSP) and its nanohybrid, silver nanoparticle/NSP (AgNP/NSP), have been developed, and the nanohybrids show a strong and general antibacterial activity in vitro. Here, their efficacy for protecting Salmonella-infected chicks from fatality and septicemia was evaluated. Both orally administrated NSP and AgNP/ NSP, but not AgNPs alone, effectively reduced the systemic Salmonella infection and mortality. In addition, quantitative Ag analyses demonstrated that Ag deposition from AgNP/NSP in the intestines was less than that from conventional AgNPs, indicating that the presence of NSP for immobilizing AgNPs reduced Ag accumulation in tissue and improved the safety of AgNPs. These in vivo results illustrated that both NSP and AgNP/NSP nanohybrid represent potential agents for controlling enteric bacterial infections.

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Silver nanoparticles as a potential antimicrobial additive for weaned pigs

Cited by 166 publications

References 37 publications

Investigating the Effect of In Ovo Injection of Silver Nanoparticles on Fat Uptake and Development in Broiler and Layer Hatchlings

Investigating the Effect of In Ovo Injection of Silver Nanoparticles on Fat Uptake and Development in Broiler and Layer Hatchlings

Potential Use of Silver Nanoparticles as an Additive in Animal Feeding

Efficacy and safety of nanohybrids comprising silver nanoparticles and silicate clay for controlling Salmonella infection

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