Silver Nanoparticles as an Intracanal Medicament: A Scoping Review

Kaukab, Azra; Gaur, Sumit; Agnihotri, Rupali; Taneja, Vani

doi:10.1155/2023/9451685

The Scientific World Journal

2023

DOI: 10.1155/2023/9451685

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Silver Nanoparticles as an Intracanal Medicament: A Scoping Review

Azra Kaukab,

Sumit Gaur,

Rupali Agnihotri

et al.

Abstract: Silver nanoparticles (AgNPs) release Ag ions with potent bactericidal and anti-inflammatory effects. They have shown promising results as an intracanal medicament for removing Enterococcus faecalis (E. faecalis), a resistant bacterium associated with root canal failures. This review summarizes the role of AgNPs as an intracanal medicament. Original research articles on AgNPs as an intracanal medicament were searched in databases such as MEDLINE (PubMed), Scopus, and Embase, resulting in 24 studies. They showed… Show more

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2024

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Cited by 3 publications

References 62 publications

(218 reference statements)

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The Push-Out Bond Strength, Surface Roughness, and Antimicrobial Properties of Endodontic Bioceramic Sealers Supplemented with Silver Nanoparticles

Navarrete-Olvera,

Niño-Martínez,

De Alba-Montero

et al. 2024

Molecules

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This study evaluated push-out bond test (POBT), surface roughness, and antimicrobial properties against Enterococcus faecalis of bioceramic sealers supplemented with silver nanoparticles (AgNPs). The sealers tested were CeraSeal®, EndoSequence® BC SealerTM, and Bio-C® Sealer. The POBT was measured with a Universal Testing Machine, and the type of failure was evaluated with a stereomicroscope. The roughness average (Sa) and peak–valley height (Sy) values were evaluated by atomic force microscopy. The bacterial growth inhibition was evaluated using a disk diffusion test, and antimicrobial activity was determined with the plate microdilution method. The POBT showed no significant difference between sealers with and those without NPs in cervical and apical thirds (p > 0.05). In the middle third, the adhesion force was significant for Endosequence BC Sealer® (p < 0.05). The results showed that the Sa and Sy parameters, when AgNPs were added, did not show a statistically significant difference compared to the groups without nanoparticles (p > 0.05). All tested sealers showed bacterial growth inhibition, but no significant difference was found. Their efficacy, in descending order of antibacterial activity when AgNPs were added, is as follows: EndoSequence® BC SealerTM > Bio-C® Sealer > CeraSeal®. The incorporation of AgNPs into bioceramics improves antimicrobial activity without affecting mechanical properties.

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The Push-Out Bond Strength, Surface Roughness, and Antimicrobial Properties of Endodontic Bioceramic Sealers Supplemented with Silver Nanoparticles

Navarrete-Olvera,

Niño-Martínez,

De Alba-Montero

et al. 2024

Molecules

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Recent Advances in the Delivery, Mechanism of Action and Antibacterial Activity of Silver Nanoparticles

Idris, N. U.,

Faruk, F. U.,

Yerima, M. I.

et al. 2024

UJMR

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Study’s Novelty/Excerpt This study comprehensively review the significant advancements in the antimicrobial application of silver nanoparticles (AgNPs), focusing on innovative delivery mechanisms such as nanogels, liposomes, and polymer-based nanoparticles. It highlights the unique physicochemical properties of AgNPs that contribute to their antibacterial efficacy, including their ability to disrupt bacterial cell membranes and inhibit biofilm formation. The review also addresses the critical challenges of cytotoxicity and delivery method refinement, emphasizing the potential of AgNPs in combating antibiotic-resistant bacteria. Full Abstract Nanoparticles,especially silver nanoparticles (AgNPs), have revolutionized various fields like microbiology, biotechnology, pharmacy, and medicine owing to their distinct properties. This research delves into the significant potential of AgNPs in antimicrobial therapy, focusing on recent advancements in their delivery mechanisms, mechanisms of action, and antibacterial efficacy. The effective targeted delivery of AgNPs to specific body sites remains a challenge, leading to innovative approaches in nanotechnology. Nanogels, liposomes, and polymer-based nanoparticles have emerged as promising delivery systems, enhancing the stability, bioavailability, and controlled release of AgNPs. The antimicrobial activity of AgNPs is rooted in their unique physicochemical properties, such as high surface area and reactivity. They disrupt bacterial cell membranes, increasing permeability, causing cell death, and interfering with intracellular components. Additionally, AgNPs have shown potential in inhibiting biofilm formation, a common defense mechanism of bacteria against antibiotics. Despite their promise, addressing issues related to cytotoxicity and refining delivery methods remains imperative. This review comprehensively addresses the challenges associated with the delivery of AgNPs, their cytotoxic effects, and their efficacy against antibiotic-resistant bacteria, highlighting their mechanism of action in bacterial eradication and biofilm inhibition.

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Effect of Silver Nanoparticles on Nonspecific Proteolysis in the Gastric Mucosa at Ulcerative Damage Modeling

Gairabekov,

Vakalishev,

Khurshidov

et al. 2024

Pharmacophore

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Silver Nanoparticles as an Intracanal Medicament: A Scoping Review

Cited by 3 publications

References 62 publications

The Push-Out Bond Strength, Surface Roughness, and Antimicrobial Properties of Endodontic Bioceramic Sealers Supplemented with Silver Nanoparticles

The Push-Out Bond Strength, Surface Roughness, and Antimicrobial Properties of Endodontic Bioceramic Sealers Supplemented with Silver Nanoparticles

Recent Advances in the Delivery, Mechanism of Action and Antibacterial Activity of Silver Nanoparticles

Effect of Silver Nanoparticles on Nonspecific Proteolysis in the Gastric Mucosa at Ulcerative Damage Modeling

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