Silver nanoparticles composition for treatment of distemper in dogs

Bogdanchikova, Nina; Vázquez-Muñoz, Roberto; Huerta-Saquero, Alejandro; Jasso, Antonio Pena; Uzcanga, Gildardo Aguilar; Díaz, Paola L. Picos; Pestryakov, Alexey; Burmistrov, V. I.; Martynyuk, O.; Gómez, Roberto Luna Vázquez; Almanza, Horacio

doi:10.1504/ijnt.2016.074536

Cited by 38 publications

(42 citation statements)

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“…Our results showed no obvious toxicity effects on the behavioural activity of shrimp in the form of erratic swimming, changes in feeding rate, atypical body colour body, and increased mortality (1 shrimp death) in all treatments by the oral route. The lack of mortality and clinical signs can be explained by the structural design of Argovit R nanoparticles having been approved by sanitary international organizations for their use in veterinary and medical applications (Vazquez-Muñoz, Avalos-Borja & Castro-Longoria, 2014;Bogdanchikova et al, 2016;Borrego et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of a new Argovit as an antiviral agent included in feed to protect the shrimpLitopenaeus vannameiagainst White Spot Syndrome Virus infection

Romo-Quiñonez

Sánchez

Álvarez-Ruíz

et al. 2020

PeerJ

Self Cite

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In this study, four experimental assays were conducted to evaluate the use of a new silver nanoparticle formulation named Argovit-4, which was prepared with slight modifications to enhance its biological activity against white spot syndrome virus (WSSV) in shrimp culture. The goals of these assays were to (1) determine the protective effect of Argovit-4 against WSSV, (2) determine whether Argovit-4 supplemented in feed exhibits toxicity towards shrimp, (3) determine whether Argovit-4 as antiviral additive in feed can prevent or delay/reduce WSSV-induced shrimp mortality, and (4) determine whether Argovit-4 supplemented in feed alters the early stages of the shrimp immune response. In bioassay 1, several viral inocula calibrated at 7 SID50(shrimp infectious doses 50% endpoint) were exposed to 40, 100, 200 and 1,000 ng/SID50 of Ag+ and then intramuscularly injected into shrimp for 96 h. In bioassay 2, shrimp were fed Argovit-4 supplemented in feed at different concentrations (10, 100 and 1,000 µg per gram of feed) for 192 h. In bioassay 3, shrimp were treated with Argovit-4 supplemented in feed at different concentrations and then challenged against WSSV for 192 h. In bioassay 4, quantitative real-time RT-qPCR was performed to measure the transcriptional responses of five immune-relevant genes in haemocytes of experimental shrimp treated with Argovit-4 supplemented in feed at 0, 6, 12, 24 and 48 h. The intramuscularly injected Argovit-4 showed a dose-dependent effect (p < 0.05) on the cumulative shrimp mortality from 0–96 h post-infection. In the second bioassay, shrimp fed Argovit-4 supplemented in feed did not show signs of toxicity for the assayed doses over the 192-h experiment. The third and fourth bioassays showed that shrimp challenged with WSSV at 1,000 µg/g feed exhibited reduced mortality without altering the expression of some immune system-related genes according to the observed level of transcriptional. This study is the first show that the new Argovit-4 formulation has potential as an antiviral additive in feed against WSSV and demonstrates a practical therapeutic strategy to control WSSV and possibly other invertebrate pathogens in shrimp aquaculture.

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Section: Discussionmentioning

confidence: 99%

“…The mechanism of action of AgNPs as an antiviral agent has been studied against several enveloped viruses (Lara et al, 2011;Bogdanchikova et al, 2016), and it has suggested. that AgNPs undergo preferential binding with viral envelope glycoproteins to inhibit viruses from binding to host cells (Elechiguerra et al, 2005;Lara et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a new Argovit as an antiviral agent included in feed to protect the shrimpLitopenaeus vannameiagainst White Spot Syndrome Virus infection

Romo-Quiñonez

Sánchez

Álvarez-Ruíz

et al. 2020

PeerJ

Self Cite

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“…Poly-shaped 52.9 N/A H9N2 [24] Carbon fullerene 2 N/A N/A N/A H1N1 [25] Peptide Research on nanomaterials for future antiviral treatments is still ongoing, as they have proven to effective for preventing HIV transmission [30] and pneumonia -influenza virus [31]-, in in vivo murine models. Also, AgNPs were effective at inactivating in vivo the Canine Distemper Virus in dogs [32]. Heparan Sulfate Proteoglycans (HSPG)-mimicking nanoparticles display broad-range antiviral activity, both in vivo and in vitro against herpes simplex virus (HSV), human papillomavirus, respiratory syncytial virus (RSV), dengue and lentivirus [33].…”

Section: Tio2npsmentioning

confidence: 99%

Nanotechnology as an Alternative to Reduce the Spread of COVID-19

Vázquez-Muñoz¹,

Lopez-Ribot²

2020

Preprint

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The current emerging COVID-19 pandemic has caused a global impact on every major aspect of our societies. It is known that SARS-Cov-2 can endure harsh environmental conditions for up to 72 h, which may contribute to its rapid spread. Therefore, effective containment strategies, such as sanitizing, are critical. Nanotechnology can represent an alternative to reduce the COVID-19 spread, particularly in critical areas, such as healthcare facilities and public places. Nanotechnology-based products are effective at inhibiting different pathogens, including viruses, regardless of their drug-resistant profile, biological structure, or physiology. Although there are several approved nanotechnology-based antiviral products, this work aims to highlight the use of nanomaterials as sanitizers for the prevention of the spread of mainly SARS-Cov-2. It has been widely demonstrated that nanomaterials are an alternative for sanitizing surfaces to inactivate the virus. Also, antimicrobial nanomaterials can reduce the risk of secondary microbial infections on COVID-19 patients, as they inhibit the bacteria and fungi that can contaminate healthcare-related facilities. Finally, cost-effective, easy-to-synthesize antiviral nanomaterials could reduce the burden of the COVID-19 on challenging environments and in developing countries.

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“…Another review deals with AgNPs as possible antiviral agents (Khandel, Kaur, Kumar, & Tiwari, ). A study shows AgNPs can inactivate viruses of different types, such as HIV‐1, monkey pox virus, hepatitis B, distemper and arenaviruses, adenovirus type 3, and Tacaribe virus replication (Bogdanchikova et al, ; Chen, Zheng, Yin, Li, & Zheng, ; Elicheguerra et al, ; Rogers, Parkinson, Choi, Speshock, & Hussain, ; Speshock, Murdock, Braydich‐Stolle, Schrand, & Hussain, ). AgNPs also inhibit the influenza virus (Mehrbod et al, ).…”

Section: Beneficial Effects Of Silver Nanoparticlesmentioning

confidence: 99%

Silver nanoparticles: Electron transfer, reactive oxygen species, oxidative stress, beneficial and toxicological effects. Mini review

Flores-López

Espinoza-Gómez

Somanathan

2018

J of Applied Toxicology

213

110

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The industry of nanotechnology has had a rapid development in the last decades. In particular, silver nanoparticles (AgNPs) have unique properties so they can be used in different industrial applications, mainly in areas such as electronics, environment, medicine, biosensors and biotechnology; as well as household and healthcare-related products, like cosmetics, due to their antimicrobial properties. These beneficial effects are also offset by the higher chemical reactivity of these NPs due to their surface area to volume ratio, leading to the increased formation of reactive oxygen species (ROS) within cells. AgNPs, however, have a dark side: they increase the formation of reactive oxygen species (ROS). With increased human exposure to AgNPs, the risk and safety standards have attracted much attention. This review highlights the beneficial and toxicological effects of AgNPs in terms of cytotoxicity and genotoxicity.

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Silver nanoparticles composition for treatment of distemper in dogs

Cited by 38 publications

References 0 publications

Evaluation of a new Argovit as an antiviral agent included in feed to protect the shrimpLitopenaeus vannameiagainst White Spot Syndrome Virus infection

Evaluation of a new Argovit as an antiviral agent included in feed to protect the shrimpLitopenaeus vannameiagainst White Spot Syndrome Virus infection

Nanotechnology as an Alternative to Reduce the Spread of COVID-19

Silver nanoparticles: Electron transfer, reactive oxygen species, oxidative stress, beneficial and toxicological effects. Mini review

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