Silver nanoparticles embedded in zeolite membranes: release of silver ions and mechanism of antibacterial action

Nagy, Amber; Harrison, Alistair; Sabbani, Supriya; Munson, Robert S.; Dutta, Prabir K.; Waldman, W. James

doi:10.2147/ijn.s24019

Cited by 97 publications

(37 citation statements)

References 34 publications

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“…Interestingly, when the levels of several stress response genes like sodB (HP0389), catalase (HP0875), fur (HP1027), tsaA (HP1536) and napA (HP0243) were assessed in the ZnO-PEI NP treated bacteria, drastic reduction in their mRNA levels were also observed (Figure S8). Indeed, treatment with different NPs has been shown to result in reduction of stress response gene specific mRNA [26]–[28].…”

Section: Resultsmentioning

confidence: 99%

The Molecular Basis of Inactivation of Metronidazole-Resistant Helicobacter pylori Using Polyethyleneimine Functionalized Zinc Oxide Nanoparticles

et al. 2013

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In view of the world wide prevalence of Helicobacter pylori infection, its potentially serious consequences, and the increasing emergence of antibiotic resistant H. pylori strains there is an urgent need for the development of alternative strategies to combat the infection. In this study it has been demonstrated that polyethyleneimine (PEI) functionalized zinc oxide (ZnO) nanoparticles (NPs) inhibit the growth of a metronidazole-resistant strain of H. pylori and the molecular basis of the anti-bacterial activity of ZnO-PEI NP has been investigated. The ZnO-PEI NP was synthesized using a wet chemical method with a core size of approximately 3–7 nm. Internalization and distribution of ZnO-PEI NP without agglomeration was observed in H. pylori cytosol by electron microscopy. Several lines of evidence including scanning electron microscopy, propidium iodide uptake and ATP assay indicate severe membrane damage in ZnO-PEI NP treated H. pylori. Intracellular ROS generation increased rapidly following the treatment of H. pylori with ZnO-PEI NP and extensive degradation of 16S and 23S rRNA was observed by quantitative reverse-transcriptase PCR. Finally, considerable synergy between ZnO-PEI NP and antibiotics was observed and it has been demonstrated that the concentration of ZnO-PEI NP (20 µg/ml) that is non-toxic to human cells could be used in combination with sub-inhibitory concentrations of antibiotics for the inhibition of H. pylori growth.

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Section: Resultsmentioning

confidence: 99%

The Molecular Basis of Inactivation of Metronidazole-Resistant Helicobacter pylori Using Polyethyleneimine Functionalized Zinc Oxide Nanoparticles

et al. 2013

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“…Atomic layer deposition enables the amount of coating material that is deposited on the surface and subsequently released during use to be readily controlled. This attribute of atomic layer deposition is beneficial for coating medical devices with materials such as silver or zinc oxide, which are thought to produce antimicrobial activity through ionic interactions 25 , 26 …”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of cultured macrophages exposed to antimicrobial zinc oxide (ZnO) coatings on nanoporous aluminum oxide membranes

et al. 2013

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Zinc oxide (ZnO) is a widely used commercial material that is finding use in wound healing applications due to its antimicrobial properties. Our study demonstrates a novel approach for coating ZnO with precise thickness control onto 20 nm and 100 nm pore diameter anodized aluminum oxide using atomic layer deposition (ALD). ZnO was deposited throughout the nanoporous structure of the anodized aluminum oxide membranes. An 8 nm-thick coating of ZnO, previously noted to have antimicrobial properties, was cytotoxic to cultured macrophages. After 48 h, ZnO-coated 20 nm and 100 nm pore anodized aluminum oxide significantly decreased cell viability by ≈65% and 54%, respectively, compared with cells grown on uncoated anodized aluminum oxide membranes and cells grown on tissue culture plates. Pore diameter (20–200 nm) did not influence cell viability.

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“…When used for sanitary purposes, the silver attacks microbes and inhibits their growth, as shown by Agion ® (Sciessent LLC, Wakefield, MA, USA). 19 A small amount of silver ions is released from the metallic surface when placed in contact with liquids. The success of this composition in water disinfection was shown once again by Petrik et al 20 The Water Research Commission Report No KV 297/12 shows the innovative use of zeolites as an adsorbing platform for silver nanoparticles as a source of silver ions for a disinfectant.…”

Section: State Of Science and Technology: Nanobased Materials Procesmentioning

confidence: 99%

Innovations in nanotechnology for water treatment

Gehrke¹,

Geiser²,

Somborn-Schulz³

2015

NSA

472

144

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Important challenges in the global water situation, mainly resulting from worldwide population growth and climate change, require novel innovative water technologies in order to ensure a supply of drinking water and reduce global water pollution. Against this background, the adaptation of highly advanced nanotechnology to traditional process engineering offers new opportunities in technological developments for advanced water and wastewater technology processes. Here, an overview of recent advances in nanotechnologies for water and wastewater treatment processes is provided, including nanobased materials, such as nanoadsorbents, nanometals, nanomembranes, and photocatalysts. The beneficial properties of these materials as well as technical barriers when compared with conventional processes are reported. The state of commercialization is presented and an outlook on further research opportunities is given for each type of nanobased material and process. In addition to the promising technological enhancements, the limitations of nanotechnology for water applications, such as laws and regulations as well as potential health risks, are summarized. The legal framework according to nanoengineered materials and processes that are used for water and wastewater treatment is considered for European countries and for the USA.

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Silver nanoparticles embedded in zeolite membranes: release of silver ions and mechanism of antibacterial action

Cited by 97 publications

References 34 publications

The Molecular Basis of Inactivation of Metronidazole-Resistant Helicobacter pylori Using Polyethyleneimine Functionalized Zinc Oxide Nanoparticles

The Molecular Basis of Inactivation of Metronidazole-Resistant Helicobacter pylori Using Polyethyleneimine Functionalized Zinc Oxide Nanoparticles

Cytotoxicity of cultured macrophages exposed to antimicrobial zinc oxide (ZnO) coatings on nanoporous aluminum oxide membranes

Innovations in nanotechnology for water treatment

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