Silver nanoparticles inhibit the function of hypoxia-inducible factor-1 and target genes: insight into the cytotoxicity and antiangiogenesis

Yang, Tieshan; Yao, Qian; Cao, Fei; Liu, Qianqian; Liu, Binlei; Wang, Xiuhong

doi:10.2147/ijn.s109695

Cited by 104 publications

(80 citation statements)

References 53 publications

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“…The HIF pathway is an essential regulator and important mediator of angiogenesis (Li et al, 2016;Yang et al, 2016). Development of HIF-1α inhibitors through 100 µm 100 µm 100 µm 50 µm 50 µm 50 µm clinical trials proposed for cancer treatment has been studied previously in humans (Onnis et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Healing of Growth Plate Cartilage by Hypoxia Inducible Factor-1α Inhibitor Apigenin on Thiram Induced Tibial Dyschondroplasia

Iqbal¹

2018

PVJ

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Section: Discussionmentioning

confidence: 99%

Healing of Growth Plate Cartilage by Hypoxia Inducible Factor-1α Inhibitor Apigenin on Thiram Induced Tibial Dyschondroplasia

Iqbal¹

2018

PVJ

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“…Endothelial microparticles enriched with Sirt6 mRNA induces EC angiogenesis, increases eNOS phosphorylation and prevents release of inflammatory chemokines in diabetic patients (159). Novel approaches like employing various metal (160)(161)(162) and inorganic NPs (163)(164)(165) have been reported to modulate angiogenesis. Many studies revealed that the shape, size and surface charge of the nanoparticles plays a crucial role in their angiogenic behavior (166,167).…”

Section: Conclusion: Future Perspectives and Novel Therapeutic Approamentioning

confidence: 99%

Role of Sirtuins in Tumor Angiogenesis

et al. 2020

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Generally, changes in the metabolic status of cells under conditions like hypoxia and accumulation of lactate can be sensed by various sensing mechanisms, leading to modulation of a number of signal transduction pathways and transcription factors. Several of the proangiogenic cytokines like VEGF, FGF, PDGF, TGF-β, Ang-2, ILs, etc. are secreted by cancer cells, under hypoxic microenvironment. These cytokines bind to their receptors on the endothelial cells and activates a number of signaling pathways including Akt/PIP3, Src, p38/MAPK, Smad2/3, etc., which ultimately results in the proliferation and migration of endothelial cells. Transcription factors that are activated in response to the metabolic status of tumors include HIFs, NF-κb, p53, El-2, and FOXO. Many of these transcription factors has been reported to be regulated by a class of histone deacetylase called sirtuins. Sirtuins are NAD + dependent histone deacetylases that play pivotal role in the regulation of tumor cell metabolism, proliferation, migration and angiogenesis. The major function of sirtuins include, deacetylation of histones as well as some non-histone proteins like NF-κB, FOXOs, PPAR , PGC1-α, enzymes like acetyl coenzymeA and structural proteins like α tubulin. In the cell, sirtuins are generally considered as the redox sensors and their activities are dependent on the metabolic status of the cell. Understanding the intricate regulatory mechanisms adopted by sirtuins, is crucial in devising effective therapeutic strategies against angiogenesis, metastasis and tumor progression. Keeping this in mind, the present review focuses on the role of sirtuins in the process of tumor angiogenesis and the regulatory mechanisms employed by them.

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“…They showed that green AgNPs have anti‐angiogenic effect on chicken embryo in dose‐dependent manner. In other study, Yang et al () reported that AgNPs show anti‐angiogenic activity by inhibition of HIF‐1 expression levels in dose‐dependent manner. They indicated that AgNPs could inhibit transcription of HIF‐1 at 100 µg/ml concentration in MCF‐7 cells.…”

Section: Introductionmentioning

confidence: 91%

Nanoparticles as new tools for inhibition of cancer angiogenesis

Goradel

Ghiyami-Hour

Jahangiri

et al. 2017

Journal Cellular Physiology

163

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Angiogenesis is known as one of the hallmarks of cancer. Multiple lines evidence indicated that vascular endothelium growth factor (VEGF) is a key player in the progression of angiogenesis and exerts its functions via interaction with tyrosine kinase receptors (TKRs). These receptors could trigger a variety of cascades that lead to the supply of oxygen and nutrients to tumor cells and survival of these cells. With respect to pivotal role of angiogenesis in the tumor growth and survival, finding new therapeutic approaches via targeting angiogenesis could open a new horizon in cancer therapy. Among various types of therapeutic strategies, nanotechnology has emerged as new approach for the treatment of various cancers. Nanoparticles (NPs) could be used as effective tools for targeting a variety of therapeutic agents. According to in vitro and in vivo studies, NPs are efficient in depriving tumor cells from nutrients and oxygen by inhibiting angiogenesis. However, the utilization of NPs are associated with a variety of limitations. It seems that new approaches such as NPs conjugated with hydrogels could overcome to some limitations. In the present review, we summarize various mechanisms involved in angiogenesis, common anti-angiogenesis strategies, and application of NPs for targeting angiogenesis in various cancers.

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Silver nanoparticles inhibit the function of hypoxia-inducible factor-1 and target genes: insight into the cytotoxicity and antiangiogenesis

Cited by 104 publications

References 53 publications

Healing of Growth Plate Cartilage by Hypoxia Inducible Factor-1α Inhibitor Apigenin on Thiram Induced Tibial Dyschondroplasia

Healing of Growth Plate Cartilage by Hypoxia Inducible Factor-1α Inhibitor Apigenin on Thiram Induced Tibial Dyschondroplasia

Role of Sirtuins in Tumor Angiogenesis

Nanoparticles as new tools for inhibition of cancer angiogenesis

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