Silver nanoparticles synthesized from Quercus brantii ameliorated ethanol-induced gastric ulcers in rats by decreasing oxidative stress and improving antioxidant systems

Safari, Saeid; Bahramikia, Seifollah; Dezfoulian, Omid

doi:10.1007/s10787-023-01284-z

Cited by 11 publications

(1 citation statement)

References 47 publications

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“…After 10 min, each stomach is then opened along the greater curvature and examined under a dissecting microscope to assess the formation of ulcers. Ulcer index and percentage of ulcer inhibition in rats were estimated ( Choudhary et al, 2013 , Safari et al, 2023 ).…”

Section: Methodsmentioning

confidence: 99%

Gastroprotective evaluation of Medicago sativa L. (Fabaceae) on diabetic rats

Chandra,

Kaleem,

Sachan

et al. 2023

Saudi Pharmaceutical Journal

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Section: Methodsmentioning

confidence: 99%

Gastroprotective evaluation of Medicago sativa L. (Fabaceae) on diabetic rats

Chandra,

Kaleem,

Sachan

et al. 2023

Saudi Pharmaceutical Journal

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Plant-based green synthesis of nanoparticles as an effective and safe treatment for gastric ulcer

Bahramikia,

Izadi

2023

Inflammopharmacol

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β-Citronellol: a potential anti-inflammatory and gastro-protective agent-mechanistic insights into its modulatory effects on COX-II, 5-LOX, eNOS, and ICAM-1 pathways through in vitro, in vivo, in silico, and network pharmacology studies

Iqbal,

Malik,

Sial

et al. 2024

Inflammopharmacol

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Background The current study aimed to evaluate the anti-inflammatory, anti-oxidant, and pronounced gastro-protective activities of β- Citronellol using in vitro, in vivo assays and in silico approaches. Methods In vitro assays, denaturation of bovine serum albumin, egg protein, and human Red Blood Cells (RBCs) membrane stabilization were performed, using Piroxicam as standard. For in vivo assessment, Histamine (0.1 ml from 1% w/v) and Formaldehyde (0.1 ml from 2% v/v) were used to mediate inflammation. In silico molecular docking and network pharmacology were employed to probe the possible target genes mediating gastroprotective effect of β-Citronellol at 25, 50, and 100 mg/kg, using indomethacin-induced (25 mg/kg i.p) gastric ulcer in rats. Moreover, Gastric tissues were evaluated for morphological, histopathological, and bio-chemical analysis of PGE2, COX-I, COX-II, 5-LOX, eNOS, ICAM-1, oxygen-free radical scavengers (SOD, CAT), and oxidative stress marker (MDA). Results β-Citronellol prevented denaturation of proteins and RBCs membrane stabilization with maximum effect observed at 6,400 µg/mL. Citronellol decreased rat’s paw edema. Network pharmacology and docking studies revealed gastro-protective potential of Citronellol possibly mediated through arachidonic acid pathways by targeting COX-I, COX-II, PGE2, and 5-LOX. Citronellol reduced the ulcer indices, and histopathological changes. Further, β-Citronellol (50 and 100 mg/kg) increased gastric PGE2, COX-1, and eNOS; while suppressing COX-2, 5-LOX and ICAM-1. Citronellol markedly enhanced the oxidative balance in isolated rat stomach tissues. Conclusions The anti-inflammatory, anti-oxidant, and gastro-protective effects of β-Citronellol against indomethacin-induced gastric ulcer model in rats through mediating COX-I, COX-II, PGE2, 5-LOX, eNOS, and ICAM-1 inflammatory markers. Graphical abstract

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Silver nanoparticles synthesized from Quercus brantii ameliorated ethanol-induced gastric ulcers in rats by decreasing oxidative stress and improving antioxidant systems

Cited by 11 publications

References 47 publications

Gastroprotective evaluation of Medicago sativa L. (Fabaceae) on diabetic rats

Gastroprotective evaluation of Medicago sativa L. (Fabaceae) on diabetic rats

Plant-based green synthesis of nanoparticles as an effective and safe treatment for gastric ulcer

β-Citronellol: a potential anti-inflammatory and gastro-protective agent-mechanistic insights into its modulatory effects on COX-II, 5-LOX, eNOS, and ICAM-1 pathways through in vitro, in vivo, in silico, and network pharmacology studies

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