Silver Nitrate Injury in the Rat Sciatic Nerve: A Model of Facial Nerve Injury

Abstract

Functional and neuropathologic data demonstrate that silver nitrate causes significant injury to the rat sciatic nerve. A 5-second cautery causes greater functional impairment and more severe axonal loss than a 1-second injury.

Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae)

“…Microscopic evaluation of axon was performed in a double-blind fashion by three individuals. Each peroneal nerve was graded for damage on a qualitative 4-point scale [19]. Normal nerve received a score of 0 (Figure 4(a)).…”

Inhibition of Large-Conductance Ca2+-Activated K+ Channels by Nanomolar Concentrations of Ag+

“…Second, symptoms resulted from acute intoxication with large doses of Ag ϩ include diarrhea, cardiovascular collapse, and convulsions (Dreisbach, 1974), conditions that might be expected to arise from BK channel inhibition (Hagen et al, 2003;Sheehan et al, 2009). Finally, both Ag ϩ treatment and BK channel gene knockout induce neuron degeneration (Wachter et al, 2002;Rü ttiger et al, 2004). Although more work will be required before a clear connection between silver toxicity and irreversible modification of BK channels by Ag ϩ can be made, our results, together with these previous findings, suggest that more attention be paid to the potential cytotoxicity of Ag ϩ .…”

“…Neuropathy has also been reported from excessive use of silver sulfadiazine or silver absorption from bone cement (Vik et al, 1985;Payne et al, 1992). In addition, experiments in rats have demonstrated that Ag ϩ causes functional impairment and axonal loss in the sciatic nerve (Wachter et al, 2002) and decreases the volume of the pyramidal cell layer in the developing hippocampus (Rungby et al, 1987). Therefore, it is particularly important to understand the mechanism and molecular targets of Ag ϩ cytotoxicity.…”

Neural outcomes after plasma knife dissection: A pathologic study and clinical correlation

“…The rat sciatic nerve is a similar size to the human facial nerve and has been used extensively as the optimal model for measuring the effects of energy-based devices on the human facial nerve. 11,12 Histologic changes included increased number of mast cells in the perineural soft tissue of 2 nerves dissected by plasma knife. Although the clinical significance of this is unknown, further study will be needed to determine whether stimulation from the plasma knife produces a surrounding inflammatory response.…”